Recombinant Mouse Peroxiredoxin-2 (Prdx2)

1. Data suggests that Prdx1 and Prdx2 in pronuclei of zygotes are involved in antioxidant mechanisms and epigenetic programming during maternal-to-zygotic transition (during ectogenesis following in vitro fertilization). PRDX1 and PRDX2 appear to be ninth and twenty-second highest expressed proteins, respectively, among 64 proteins identified in mouse zygotes. PMID: 29503398
2. our data highlight a novel role of Prx2 in iron homeostasis. Prx2 is a key cytoprotector against IO that is induced either by iron supplementation or due to chronic hemolysis as in beta-thalassemia. PMID: 28793778
3. The data indicate that Prx2 is able to interrupt the hypoxia induced vicious cycle involving oxidation-inflammation-autophagy in the pathogenesis of pulmonary hypertension. PMID: 28801243
4. one of the antioxidant enzymes, Prdx-2, was abundantly nitrosylated and temporarily reduced in antioxidant activity, causing transient endogenous hydrogen peroxide (H2O2) accumulation and subsequent X-box binding protein-1s/phosphatidylinositol 3-kinase pathway activation.Prdx-2 nitrosylation could be a potent strategy to affect the pluripotent stem cell-derived cardiomyogenesis. PMID: 27261193
5. Oxidative stress promotes PRX2 and PRX3 hyperoxidation and attenuates pro-survival signaling in aging chondrocytes. PMID: 26797130
6. The ventral signal observed for Prdx2 from early stages colocalized with motor neuron markers Isl1/2 and FoxP1 and strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord. PMID: 25975898
7. Prx2 glutathionylation is a favorable reaction that can occur in cells under oxidative stress and may have a role in redox signaling. GSH/Grx1 provide an alternative mechanism to thioredoxin and thioredoxin reductase for Prx2 recycling. PMID: 26601956
8. PrxII functions as a protective antioxidant enzyme against collagen-stimulated platelet activation and platelet-dependent thrombosis PMID: 25802339
9. Prx I and Prx II appear to have a tight association with the mechanism underlying the protection of ESC stemness in developing teratomas. PMID: 24715692
10. results suggest that inactivation of PrxII is important for the stability of FoxO1 protein, which subsequently mediates Foxp3( ) Treg cell development, thereby attenuating colonic inflammation PMID: 24048895
11. PRDX2 neutralizes hydrogen peroxide generated in vivo under the transient hypoxic conditions experienced as erythrocytes pass through the microcirculation. PMID: 23215741
12. PRX2 battles poly(ADP-ribose) polymerase 1- and p53-dependent prodeath pathways after ischemic injury PMID: 23429506
13. These findings suggest that Prx II plays an important role in preventing hemolytic anemia from oxidative stress by binding to Hb as a decameric structure to stabilize it. PMID: 22960070
14. These results strongly demonstrate that Prx II plays an essential role in maintaining normal erythropoiesis by protecting DNA damage. PMID: 22749995
15. This study shows that both fructose and glucose-sweetened liquid consumption results in fatty liver, with both sweeteners showing similar peroxiredoxin-2 expression. PMID: 22254090
16. Prx-2 is upregulated via the PI3K/NF-kappaB pathway and attenuates oxidative stress during muscle differentiation and regeneration. PMID: 21902453
17. Peroxiredoxin 2 is an important modulator of angiotensin II-induced podocyte injury. PMID: 21814176
18. Prdx2 is a specific peroxidase that inhibits atherogenic responses in vascular and inflammatory cells in ApoE deficient mice. PMID: 21835911
19. The data of this study suggested that Prx II help maintain hippocampal synaptic plasticity against age-related oxidative damage. PMID: 19577336
20. peroxiredoxin 2 may be involved in the modulation of maternal-fetal tolerance and that insufficient expression of this protein may correlate with increased embryo loss in CBA/J x DBA/2J mice PMID: 21328451
21. increased expression of Prx2 correlates with the severity of the disease and that the amount of Prx2 bound to the membrane is markedly reduced in beta-thal mouse erythrocytes. PMID: 20488244
22. peroxiredoxin-2, glutathione peroxidase-1, and catalase have roles in erythrocyte oxidative metabolism PMID: 19969073
23. crystal of peroxiredoxin II obtained by the sitting-drop vapour-diffusion method diffracted to 1.77 A resolution at 100 K. PMID: 20208180
24. Suggest that Prx II plays a key antioxidation role in the maturation of oocytes and development of early embryos. PMID: 19899112
25. induced by oxidative and nitrosative stress in pancreatic beta cells PMID: 12107731
26. results suggest that peroxiredoxin II plays a major role in protecting erythrocytes from oxidative stress in mice PMID: 12586629
27. Prx II is recruited to PDGFR upon PDGF stimulation, and suppresses protein tyrosine phosphatase inactivation; Prx II also leads to the suppression of PDGFR activation in primary culture and a murine restenosis model PMID: 15902258
28. These results suggest that peroxiredoxin II may function as an enzymatic antioxidant to prevent cellular senescence and skin aging. PMID: 16109412
29. Prx II inhibits the immune cell responsiveness, which may be regulated by scavenging the low amount of reactive oxygen species (ROS). PMID: 16290204
30. The results of this study provide direct evidence that the reduction of TR1 levels in malignant cells is antitumorigenic and suggest that the enzyme is a prime target for cancer therapy. PMID: 16565519
31. cellular senescence in Prx II-/- MEF cells is mediated by ERK activation but not by NFkappaB activation PMID: 17050172
32. reactive oxygen intermediates and subsequent oxidative stress generated from thioredoxin reductase are likely to contribute to paraquat-induced lung toxicity PMID: 17229725
33. Essential negative regulator of lipopolysaccharide-induced inflammatory signaling through modulation of reactive oxygen species synthesis. PMID: 17325201
34. Nitrosative stress leads to protein glutathiolation, increased s-nitrosation, and up-regulation of Prx VI, but not Prx II or Prx III in the heart PMID: 18426799
35. findings suggest that B-cell activating factor (BAFF) and toll-like receptor 4 expressions are differentially regulated by peroxiredoxin II and TLR4 protein level may not be crucial in OVA-induced asthma PMID: 18442801
36. in situ hybridization demonstrated that the sense and antisense transcripts were localized in almost the same limited areas of brain, testis, and spleen. It also revealed that the sense and antisense transcripts coexisted in Purkinje cells PMID: 18758163
37. peroxiredoxin II may be a unique antioxidant in the cardiac system and may represent a potential target for cardiac protection from oxidative stress-induced injury. PMID: 19030911
38. observed in the cytoplasm and residual bodies of spermatocytes and spermatids, after spermiation became confined to the mitochondrial sheath of the sperm tail midpiece PMID: 19208552

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KEGG: mmu:21672

STRING: 10090.ENSMUSP00000005292

UniGene: Mm.347009