Recombinant Mouse Platelet-derived growth factor subunit A (Pdgfa)

1. PDGF-A signaling is involved in myofibroblast proliferation and migration. PMID: 29636361
2. These studies uncover PI3K/AKT2 as a direct PDGFA target that is activated in adipocyte stem cells. PMID: 27746098
3. stronger fibrotic effect generated by Platelet-derived growth factor alpha overexpression was mediated by Platelet-derived growth factor receptor alphalpha in cardiac interstitial mesenchymal cells PMID: 27816607
4. PDGF-AA impairs endothelium-dependent vasodilation and PDGF-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1/5- and SMAD4-dependent mechanisms. PMID: 26769046
5. Both cell proliferation and hair inductive activity in murine DPCs are maintained by the synergistic effect of fibroblast growth factor 2 and platelet-derived growth factor receptor alpha. PMID: 25975959
6. Primary high invasive Glioma initiating cells SU3 contribute to transformation of adjacent normal host glial cells in local tumor microenvironment possibly via PDGF/PDGFR signaling activation. PMID: 26049020
7. Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts. PMID: 25116623
8. senescent cells have a role in optimal wound healing through secretion of PDGF-AA PMID: 25499914
9. leading to a PDGF-responsive SRF-driven transcriptional program in the midface PMID: 25453829
10. Platelet-derived growth factor plays an integral role in mediating TGF-beta1-dependent mesenchymal stem cell stiffening. PMID: 24093435
11. GPIbalpha blockade reverses production of interleukin (IL)-1alpha by microglia in response to cerebral ischemia in animals with Streptococcus pneumoniae infection. PMID: 24644058
12. these data uncover an early role of PDGF signaling in primitive endoderm cell survival. PMID: 23733391
13. PDGFA-long isoform plays a critical role in normal development of the lung, intestine, and vertebral column. PMID: 23938297
14. study examined lung fibroblasts (LF) to learn whether PDGFRalpha expression distinguished a population of precursor cells with enhanced proliferative and migratory capabilities; PDGF-A and Shh both increased cytokinesis and chemotaxis of LF but through different mechanisms PMID: 23748534
15. Nuclear localization of FoxO3a, an important regulator of p27(kip1) gene-expression, correlates with diminished proliferation of the PDGFRalpha-expressing LF subpopulation. PMID: 23819440
16. Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung PMID: 22949635
17. These results suggest that PDGF functions as a positive regulator in the final differentiation phase of tongue muscle cells in mouse embryos. PMID: 22264326
18. the serum-induced increase in cell surface GLUT4 levels is not due to inhibition of its internalization and is not mediated by insulin, PDGF, IGF-1, or HGF PMID: 21187969
19. PDGF protects neurons from H2O2-induced cytotoxicity, and that PI-3K/Akt and MAPK pathways are involved in the protective effects; PDGF-BB exerted more potent neuroprotective effects than PDGF-AA PMID: 19998489
20. PDGF-A/PDGF alpha-receptor signaling required for lung growth and the formation of alveoli but not for early branching of the lung epithelium PMID: 11803579
21. PDGF signaling through the alpha receptor is an important event downstream of Sry in testis organogenesis and Leydig cell differentiation PMID: 12651897
22. PDGF system is highly expressed in the epididymis and suggest that PDGF could be involved in the maintenance of morphological structure and functional control of this organ. PMID: 14522834
23. PDGF controls c-myc expression through a JNK- and AP-1-dependent signaling pathway PMID: 14523011
24. In vitro cultures supporting the spontaneous generation of functional cardiac myocytes from murine BMCs demonstrated induced expression of PDGF-A and -B. PDGF-AB enhances the generation of BMC-derived cardiac myocytes in mouse hearts. PMID: 14963008
25. PDGFRalpha and PDGFA are critical regulators for the continued epithelial-mesenchymal interaction during tooth and palate morphogenesis PMID: 15543606
26. PDGF regulates gene expression through a Src Family Kinase-secific pathway that is distinct from the Ras-MAPK and PI3K pathways, and SFKs signal gene expression by enhancing mRNA stability PMID: 15637050
27. thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor PMID: 15890262
28. the complete PDGF-A/PDGFR-alpha signaling system is present in murine reproductive tissues, but the distribution of the long and short isoforms of PDFG-A differs PMID: 15932761
29. loss of FSH-R signaling causes an imbalance of PDGF family members predisposing the abnormal ovarian follicular environment for inducing tumorigenesis in aging FORKO mice PMID: 16344272
30. FGF and PDGF have roles in cell proliferation and migration in osteoblastic cells PMID: 17852407
31. One mechanism accounting for the PDGF induction of Glut4 translocation is the suppression of the Munc18c negative regulation of Syntaxin 4 function. PMID: 17916632
32. study identified PDGF-A as a candidate epicardium-derived secreted mitogen PMID: 18297729
33. During kidney development, PDGFR beta-mediated reactive oxygen species generation and Ca(2+) influx suppress PDGF AA-induced chemotaxis in metanephric mesenchyme. PMID: 19019919
34. These results imply a central role of NFI-C in the interplay of the two signaling pathways and in regulation of the progression of tissue regeneration. PMID: 19752192

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KEGG: mmu:18590

STRING: 10090.ENSMUSP00000075463

UniGene: Mm.2675