Recombinant Mouse Pro-MCH (Pmch)

1. our experiments reveal an insulin-dependent activation of MCH neurons in obesity, which contributes via distinct mechanisms to the manifestation of impaired locomotor activity and insulin resistance. PMID: 27926856
2. Results indicate that olanzapine reduced accumbens nucleus GABAergic transmission and that MCH is necessary for the hypolocomotor effects of olanzapine PMID: 26092201
3. The present work is the first study to systematically compare the effects of MCH signaling on behavioral and metabolic phenotypes.[meta-analysis] PMID: 24924345
4. A functional cross-talk between MCH and IL-10 prevents resolution of inflammation in experimental colitis. PMID: 24556508
5. acute activation of MCH neurons is sufficient, but not necessary, to trigger the transition from NREM to REM sleep and MCH neurons also play a role in the initiation and maintenance of NREM sleep. PMID: 24828644
6. Sleep induction at a circadian time when all of the arousal neurons are active indicates that MCH stimulation can powerfully counteract the combined wake-promoting signal of the arousal neurons PMID: 23785141
7. Rat prepro-MCH is processed into three neuropeptides: melanin-concentrating hormone, neuropeptide-glutamic acid-isoleucine (NEI), and Neuropeptide-glycine-glutamic acid (NGE). PMID: 1327720
8. We conclude that MCH neurons regulate glucose tolerance through signaling molecules other than MCH. PMID: 23365238
9. MCH was found to promote intestinal tumorigenesis at least in part by inhibiting epithelial cell apoptosis PMID: 22848656
10. AgRP-expressing neurons play a critical role in mediating the metabolic syndrome and infertility of Lep(ob/ob) mice, whereas MCH-expressing neurons have only a minor role PMID: 22232663
11. The hypothalamic inputs through MCH play an important role in regulating sensory integration from olfactory pathways. PMID: 21669232
12. Studies suggest that rat and mouse MCH neurons are differentially involved in anatomical networks that control feeding and the sleep/wake cycle. PMID: 21103352
13. Data suggest that the increased food intake and increased energy expenditure of Scd1-/- mice are independent of the neuropeptide melanin-concentrating hormone. PMID: 19883709
14. importance of MCH in integration of energy homeostasis downstream of leptin and, in particular, the role of MCH in regulation of energy expenditure PMID: 12897241
15. MCH triggers hyperphagia in BRS-3-deficient mice PMID: 14988239
16. The hypothalamic arousal peptide hypocretin/orexin evoked a direct inward current and increased excitatory synaptic activity and spike frequency in the normally silent MCH neurons. PMID: 15157424
17. enhanced wheel running activities in mice lacking either MCH or its cognate receptor PMID: 15544841
18. These studies reinforce the important role of MCH in energy homeostasis and indicate that MCH is a plausible target for antiobesity therapy. PMID: 15731402
19. MCH ablation improves the long-term outcome for several indicators of the aging process. PMID: 16443777
20. We propose that alpha-DB plays a role in a structure or regulation mechanism unique to MCH-expressing neurons. PMID: 18314094
21. MCH has a role in inflammatory processes in the intestine PMID: 18650383
22. The results of this study support a role for MCH in vigilance state regulation in response to changes in energy homeostasis PMID: 18809470
23. This study showed increased expression of MCH mRNA with fasting and in mice lacking leptin. It also demonstrated that administration of MCH in the lateral ventricle leads to increased feeding. PMID: 8637571

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KEGG: mmu:110312

STRING: 10090.ENSMUSP00000044352

UniGene: Mm.391436