Recombinant Mouse Pro-neuregulin-3, membrane-bound isoform(Nrg3),partial

Code CSB-YP016079MO1
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Source Yeast
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Code CSB-EP016079MO1
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Source E.coli
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Code CSB-EP016079MO1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP016079MO1
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Source Baculovirus
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Code CSB-MP016079MO1
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Nrg3
Uniprot No. O35181
Alternative Names Nrg3; Pro-neuregulin-3, membrane-bound isoform; Pro-NRG3
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors.
Gene References into Functions
  1. Studied the physiologic role of neuregulin3 (NRG3) in regulating glutamatergic transmission in pyramidal neurons. Found NRG3 regulates the SNARE-complex assembly, and NRG3 knockout causes display behavior deficits related to mental illness. PMID: 29463705
  2. Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits. PMID: 28147272
  3. This study demonistrated that Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action. PMID: 24703509
  4. NRG1beta and NRG3 can promote the proliferation of mouse spermatogonia. PMID: 21837948
  5. a Neuregulin3 signaling pathway is involved in specification of mammary gland morphogenesis PMID: 16140987
  6. used positional cloning to narrow the interval containing scaramanga (ska) to a 75.6-kb interval containing the distal part of the Neuregulin3 (Nrg3) gene PMID: 16140987

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Subcellular Location [Pro-neuregulin-3, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-3]: Secreted.
Protein Families Neuregulin family
Tissue Specificity Expressed in sympathetic, motor, and sensory neurons.
Database Links

KEGG: mmu:18183

STRING: 10090.ENSMUSP00000136884

UniGene: Mm.258705

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