Recombinant Mouse Profilin-1 (Pfn1)

1. Profilin1 is expressed in osteocytes and regulates cell shape, migration and bone mass. PMID: 28233307
2. overexpression of profilin is sufficient to induce cardiomyocyte hypertrophy and sarcomeric remodelling, and silencing of profilin attenuates the hypertrophic response PMID: 26956799
3. Pfn1 is a novel target of BMP and suppresses BMP-induced differentiation of osteoblasts at least in part via transcriptional event. PMID: 26271366
4. knockdown of either profilin 1 or profilin 2a led to a significant decrease in cell spreading of astrocytes. Moreover, both isoforms proved to be crucial for forskolin-induced astrocytic stellation. PMID: 25629407
5. Inactivation of profilin 1 impaired the radial migration of cerebellar granule neurons PMID: 25495756
6. Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. PMID: 25187265
7. Depleting FMNL1, another Formin family member, resulted in reduced mDia1 expression, while RhoA inhibition did not alter mDia1 expression, which indicated that there was a FMNL1-mDia1-Profilin1 signaling pathway in mouse oocytes. PMID: 25447542
8. association of cortactin with Pfn-1 is regulated by c-Abl-mediated cortactin phosphorylation PMID: 24700464
9. In glioblastomas endothelial cell-specific Pfn-1 phosphorylation elevates HIF-1alpha expression leading to vascular abnormalities and tumor progression. PMID: 24747440
10. Pfn1 as a key effector of the integrin linked kinase/Rho/ROCK pathway which acts in parallel with integrin beta1/LCK/Rac1 and regulates Schwann cells lamellipodia formation, radial sorting and myelination during peripheral nervous system maturation. PMID: 24598164
11. pfn1 at least partially acts through the axis of pfn1/Galpha13/EGR1 to regulate stem cell retention and metabolism in the bone marrow. PMID: 24385538
12. findings indicate that pfn haploinsufficiency protects against diet-induced insulin resistance and inflammation by modulating white adipose tissue immune homeostasis. PMID: 23884883
13. The results of this study found that the profilin1 is crucially important for brain development, but dispensable for the physiology of excitatory synapses. PMID: 22864186
14. Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. PMID: 23246311
15. It was shown that activation of VEGF receptor kinase-2 and Src induces profilin 1 phosphorylation in the cell leading edge, promoting profilin 1 binding to actin and actin polymerization. Profilin 1 phosphorylation is critical for angiogenesis. PMID: 23000962
16. Pfn1 is a critical molecule for the skeletal development, and this could be at least in part associated with the retardation of cell migration PMID: 22773831
17. ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. PMID: 22693641
18. Loss of profilin1 had no adverse effects on the morphology and function of excitatory synapses. PMID: 22253883
19. Profilin1 ablation from mouse brains leads to a cerebellar hypoplasia, aberrant organization of cerebellar cortex layers and ectopic Cerebellar granule neurons (CGNs). PMID: 22081137
20. during elongation from profilin-actin, the dissociation of profilin from the growing barbed end is not coupled to Pi release or to ATP cleavage on the terminal subunit PMID: 21980262
21. Microtubule-dependent localization of mRNA encoding the actin regulatory protein profilin to sites in mouse embryonic fibroblasts, which express enhanced actin polymerization. PMID: 20129697
22. tumor suppressor function of PFN1 requires a functional actin binding site PMID: 14767055
23. Upregulation of profilin mRNA in the hippocampus is induced by entorhinal deafferentation and profilin is involved in microglial activation associated with morphological change, migration, and phagocytic behavior of microglial cells. PMID: 15139017
24. In cerebral cortex and hippocampus profilin I immunostaining was associated predominantly with dendrites and was present in a subset of dendritic spines. In contrast, profilin I in cerebellum was associated primarily with presynaptic structures. PMID: 15654839
25. ATP hydrolysis control of filament assembly from profilin-actin requires formin PMID: 17210567
26. pfn levels modulate processes critical for early atheroma formation and suggest that pfn heterozygosity confers atheroprotection through combined endothelial- and macrophage-dependent mechanisms PMID: 17615372
27. profilin 1 has a role in vascular hypertrophy and hypertension PMID: 17942408
28. Results demonstrate that profilin 1 is not required for actomyosin ring formation in dividing chondrocytes but necessary to generate sufficient force for abscission during late cytokinesis. PMID: 19262563

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KEGG: mmu:18643

STRING: 10090.ENSMUSP00000018437

UniGene: Mm.2647