Recombinant Mouse Protein scribble homolog (Scrib), partial

1. Scribdeficient hematopoietic stem cells reveal impaired migratory capacity. PMID: 30083817
2. Results identify a key planar cell polarity (PCP) protein, Scrib, as one of the fundamental scaffold proteins that enable hippocampal glutamatergic synapses to mature and to express bidirectional plasticity required for memory formation. Study offers a unique insight into the mechanism by which the PCP protein Scrib can regulate memory formation at postnatal stages. PMID: 28968740
3. In the Scrib mutant, despite severe neural tube defects, epF and preBotC neurons settled at their expected hindbrain positions. Furthermore, both networks remained capable of generating rhythmically organized, respiratory-related activities and exhibited normal sensitivity to pharmacological agents known to modify respiratory circuit function. PMID: 28583412
4. SCRIB is a positive regulator of mammary epithelial cell proliferation during pregnancy. PMID: 27179074
5. Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib. PMID: 28007914
6. SCRIB uncouples reactive oxygen species-dependent bacterial killing activity from M1 polarization and inflammatory functions of macrophages PMID: 27694890
7. we provide genetic evidence of a unique link between skin carcinogenesis and loss of the epithelial polarity regulator Scrib, emphasizing that Scrib exerts a wide-spread tumor suppressive function in epithelia. PMID: 26376988
8. The polarity protein Scribble regulates myelination and remyelination in the central nervous system. PMID: 25807062
9. Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate. PMID: 25704816
10. Scrib is a novel proinflammatory regulator in endothelial cells, which maintains the protein expression of GATA-like protein-1. PMID: 26205961
11. The Scrib-Rac1 interaction plays a crucial role in the organization of developing cardiomyocytes and formation of the ventricular myocardium. PMID: 25139745
12. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors PMID: 24276238
13. findings, based on a definitive genetic mouse model provide fundamental insights into mammary duct maturation and homeostasis and reveal that Scrib loss activates a MAPK/Fra1 pathway that alters mammary progenitor activity PMID: 24852022
14. The Scribble knockout fetus exhibits exomphalos (intact and ruptured), in contrast to the original published phenotype of gastroschisis. PMID: 24094954
15. Scrib is required to maintain epithelial identity and that loss of Scrib can culminate in EMT, mediated, at least in part, through TGFbeta signaling. PMID: 24095903
16. B cell differentiation does not require polarity proteins of the Scribble complex, and the findings do not support a role for asymmetric cell division in B cell activation and differentiation. PMID: 23653213
17. Scrib is required for normal lung epithelial organisation and lumen morphogenesis by maintaining cell-cell contacts. PMID: 23195221
18. while Scribble seems to be important for general epithelial cell and pronephros development, it appears to be dispensable for podocyte function and development PMID: 22586490
19. Mutation in the planar cell polarity gene, Scrib, and a mutation in caspase-3 gene have the most profound effect in controlling neural development. PMID: 21515572
20. Scrib is indispensable for prostate homeostasis. Scrib heterozygosity initiated prostate hyperplasia, while targeted biallelic Scrib loss predisposed mice to prostate intraepithelial neoplasia. PMID: 21965329
21. the phosphorylation state of Scribble regulates its complex formation with the E-cadherin-catenin system and may control cadherin-mediated cell-cell adhesion. PMID: 21146521
22. Immature T-cell clustering and efficient differentiation require the polarity protein Scribble. PMID: 21189299
23. Our data identify Scrib1 as a crucial regulator of brain development and spine morphology. PMID: 20660256
24. Heterozygotes are incompletely penetrant for a circled-tail phenotype, while homozygotes die at birth of a severe neural tube defect. PMID: 12112872
25. Scrb1, encodes a member of the LAP protein family related to Drosophila scribble.Disruption of scribble (Scrb1) gene causes severe neural tube defects in the circletail mouse PMID: 12499390
26. mutation in Scrb1 results in disruptions in the polarization of stereociliary bundles in mouse cochlea due to defects in the direction of movement and/or anchoring of the kinocilium within each hair cell PMID: 12724779
27. The observed localization of Dlg-1 and Scrib with cadherins suggests that these proteins may play roles in cell adhesion, polarity and proliferation, as they do in invertebrates, suggesting cross-species conservation of function for these PDZ proteins. PMID: 16402019
28. data underscore the role of Scrib in cell migration and show the strong impact of Scrib in the function of PAK and Rac, two key molecules implicated in this process PMID: 18716323
29. Study demonstrates that scribble inhibits breast cancer formation and that deregulation of polarity pathways promotes dysplastic and neoplastic growth in mammals by disrupting morphogenesis and inhibiting cell death. PMID: 19041750
30. This is the first study to demonstrate the involvement of Dlg1, Scrib, and Lgl1 in a mouse with ocular adenocarcinoma and the simultaneous involvement of these proteins in the same cancer. PMID: 19098995
31. Scribble functions downstream of beta-catenin to cluster synaptic vesicles at developing synapses. PMID: 19458197

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KEGG: mmu:105782

STRING: 10090.ENSMUSP00000002603

UniGene: Mm.25568