Recombinant Mouse Rap guanine nucleotide exchange factor 4 (Rapgef4), partial

1. Epac2(-/-) mice exhibited a wide range of mood disorders, including anxiety and depression with learning and memory deficits in contextual and cued fear-conditioning tests without affecting Epac1 expression or PKA activity. PMID: 27598965
2. PACAP could trigger astrocytic differentiation of neural stem cells via Epac2 activation. PMID: 26645637
3. Epac2, but not Epac1 has a role in decreasing severity of ischemic retinopathy after retinal ischemia/reperfusion injury PMID: 25985753
4. cAMP-GEF II plays a key role in hippocampal functions including behavioral flexibility. PMID: 26104314
5. data suggest that cAMP elevation uses an Epac2-dependent pathway to promote transmitter release, and that Epac2 is required to maintain the readily releasable pool at Mossy Fiber synapses in the hippocampus. PMID: 25904804
6. Epac1 primarily is capable of inhibiting remodeling processes, whereas Epac2 primarily increases inflammatory processes in vivo PMID: 25103224
7. EPAC1 and EPAC2 are critical signaling intermediates in osteoclast differentiation that permit RANKL-stimulated NFkB nuclear translocation and actin rearrangements PMID: 25122553
8. Data suggest that sulfonylureas stabilize Epac2A in its open, active state and provide insight for the development of drugs that target Epac2A. PMID: 24150255
9. data show the expression EPAC is altered in the cortex, striatum and midbrain of HPRT knockout mouse; propose that the alterations in EPAC/RAP1 signaling and cell migration in HPRT deficiency are crucial for neuro-developmental events that may contribute to neurological dysfunctions in Lesch-Nyhan syndrome PMID: 23804752
10. DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms. PMID: 23861833
11. Epac2 localization is dynamically controlled by cAMP as well as by Ca(2+)-mediated activation of Ras. PMID: 23633676
12. EPAC2A is required for potentiating the early dynamic increase in islet calcium levels after glucose stimulation, which is reflected in potentiated first-phase insulin secretion. PMID: 23578994
13. there is a gut-heart GLP-1R-dependent and ANP-dependent axis that regulates blood pressure and involves Epac2 PMID: 23542788
14. beta1-induced adrenergic-dependent arrhythmias are less inducible in Epac2-knockout versus wild-type mice. PMID: 23363625
15. This study demonistrated that exhibited specific impairments in social and communication behavior displayed specific alterations in cortical columnar organization in the somatosensory cortex. PMID: 22915127
16. analysis of autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC) and EPAC2 PMID: 21873431
17. Phospholipase c-epsilon is a determinant of mouse islet insulin secretion that is under the control of Epac2. PMID: 21478675
18. Phospholipase C-eta was found to be expressed in mouse beta-cells, and knockout of that gene disrupts the action of exendin-4 to facilitate calcium-induced calcium release in the beta-cells of these mice. PMID: 21041529
19. Piccolo serves as a Ca(2+) sensor in exocytosis in pancreatic beta-cells and the formation of a cAMP-GEFII.Rim2.Piccolo complex is important in cAMP-induced insulin secretion PMID: 12401793
20. Mutational analysis suggests a model for cAMP-induced Epac activation with rigid body movement of the regulatory region, the features of which are universally conserved in cAMP-regulated proteins. PMID: 16452984
21. cAMP at least partially regulates proglucagon gene expression via the Epac-Ras/Rap-Raf-MEK-ERK signaling pathway PMID: 16644915
22. Northern blot analysis and in situ hybridization suggested that Epac1 and Epac2 mRNAs were transcribed in the seminiferous epithelia of the testis PMID: 17077580
23. These data indicate that Epac2/Rap1 signaling is essential in regulation of insulin granule dynamics by cAMP, most likely by controlling granule density near the plasma membrane. PMID: 18040047
24. AKAP150 acts as a key regulator in the two cAMP pathways to control PKB/Akt phosphorylation. PMID: 18565730
25. structure of Epac2 in complex with a cAMP analogue (Sp-cAMPS) and RAP1B by X-ray crystallography and single particle electron microscopy PMID: 18660803
26. Ras and cAMP regulate Epac2 function in a parallel fashion and the Ras-Epac2 interaction is required for the cAMP-dependent activation of endogenous Rap1 by Epac2. PMID: 18824540
27. Results are consistent with a cAMP/Epac2/Rap1-mediated signaling that could exert its action, among others, through RA-RhoGAP to promote the progression of spermatogenesis. PMID: 18937323
28. Cyclic AMP-dependent Epac2 signals to ERK1/2 and Akt upon activation of H-Ras, and is involved in BCR-induced growth arrest and apoptosis in WEHI-231 cells. PMID: 19167486
29. splicing variant Epac2B, which lacks the first cAMP-binding domain A in the N-terminus but has the second cAMP-binding domain B of Epac2A, possesses GEF activity towards Rap1, as was found for Epac2A PMID: 19170062

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KEGG: mmu:56508

STRING: 10090.ENSMUSP00000088336

UniGene: Mm.196153