Recombinant Mouse Regulating synaptic membrane exocytosis protein 1 (Rims1), partial

1. Postsynaptic RIM1 in hippocampal CA1 region is required for basal NMDAR-, but not AMPA receptor (AMPAR)-, mediated synaptic responses, and contributes to synaptic plasticity and hippocampus-dependent memory. Moreover, RIM1 levels in hippocampal neurons influence both the constitutive and regulated NMDAR trafficking, without affecting constitutive AMPAR trafficking. PMID: 29891949
2. Here, the authors show that exophilin-8 accumulates granules in the cortical F-actin network not by direct interaction with myosin-Va, but by indirect interaction with a specific form of myosin-VIIa through its previously unknown binding partner, RIM-BP2. PMID: 28673385
3. RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions. PMID: 27537484
4. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47. PMID: 28377503
5. The function of RIM1/2 at rod ribbons is to enhance Cav1.4 channel activity, possibly through direct or indirect modulation of the channel. PMID: 26400943
6. Experiments with single Rim 1/2 gene inactivation at the large calyx of Held synapse show largely overlapping roles of the two major Rim genes in vesicle priming/docking PMID: 25343783
7. RIM1alpha can influence short-term plasticity at cerebellar parallel-fibre synapses. PMID: 23999086
8. betaARs couple to a cAMP/Epac/PLC/Munc13-1/Rab3a/RIM1a-dependent pathway to enhance glutamate release at cerebrocortical nerve terminals. PMID: 24036110
9. RIM1alpha has a role in synaptic vesicle tethering. PMID: 23712261
10. Presynaptic plasticity and function of RIM1a play an important part in the neuron's adaptive response to aberrant electrical activity following pharmacologically induced status epielepticus. PMID: 22956829
11. The interaction between RIM1alpha and Munc13-1 is required for presynaptic long-term plasticity PMID: 21849565
12. Data suggest that RIM1/2 proteins co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic Ca(2)+ channel density and vesicle docking at the active zone. PMID: 21262468
13. In addition to RIM1alpha's involvement in multiple behavioral abnormalities, these data suggest that alterations in presynaptic forms of short-term plasticity are linked to alterations in prepulse inhibition, a measure of sensorimotor gating. PMID: 20392954
14. RIM1alpha interacts with several active zone molecules, including Munc13-1 and alpha-liprins, to form a protein scaffold in the presynaptic nerve terminal. PMID: 11797009
15. required for presynaptic long-term potentiation. PMID: 11797010
16. Results suggest that protein kinase A-mediated phosphorylation of the active zone protein RIM1alpha at a single N-terminal site induces presynaptic long-term potentiation. PMID: 14532002
17. Mice with a synaptotagmin 1 mutation, which lowers release probability, and mice with Rab3A deletion, which abolishes presynaptic long-term potentiation, the combination of presynaptic abnormalities in RIM1alpha mice severely alters learning and memory. PMID: 15066271
18. Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2 PMID: 16704978
19. These data demonstrate that alpha-RIMs are not essential for synapse formation or synaptic exocytosis, but are required for normal Ca(2+)-triggering of exocytosis. PMID: 17124501
20. A possible role for RIMS1 in the enhancement of cognitive function at least in this kindred is suggested. PMID: 17237123
21. Proteasome-mediated regulation of RIM1 and synaptic transmission is mediated by SCRAPPER (synapse localized E3 ubiquitin ligase). PMID: 17803915
22. this difference in exploratory behavior correlated with genotype specific changes in rapid eye movement and deregulated release of norepinephrine in the cortex and basal amygdala of the Rim1 alpha knockout mice PMID: 18495360
23. Demonstrate that the mouse RIM1 arginine-to-histidine substitution (R655H), which corresponds to the human CORD7 mutation, modifies RIM1 function in regulating VDCC currents elicited by the P/Q-type Ca(v)2.1 and L-type Ca(v)1.4 channels. PMID: 18690027
24. phosphorylation of serine-413 of RIM1alpha is not essential for PKA-dependent long-term presynaptic plasticity in vivo, suggesting that PKA operates by a different mechanism despite the dependence of long-term presynaptic plasticity on RIM1alpha PMID: 18799741
25. These results reveal the molecular mechanisms underlying the induction of presynaptic LTP at cortico-LA synapses and indicate that RIM1alpha-dependent LTP may involve changes in Ca(2+)-release coupling. PMID: 18815362
26. the RIM1 gene encodes two different isoforms that perform overlapping but distinct functions in neurotransmitter release PMID: 19074017

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KEGG: mmu:116837

UniGene: Mm.380549