Recombinant Mouse Reticulon-1(Rtn1),partial

Code CSB-YP811680MO1
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Source Yeast
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Code CSB-EP811680MO1
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Source E.coli
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Code CSB-EP811680MO1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP811680MO1
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Source Baculovirus
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Code CSB-MP811680MO1
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Rtn1
Uniprot No. Q8K0T0
Alternative Names Rtn1; Nsp; Reticulon-1; Neuroendocrine-specific protein
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.
Gene References into Functions
  1. These data suggest that endoplasmic reticulum stress plays a major role in podocyte injury in diabetic nephropathy and RTN1A might be a key regulator of reticulum stress stress in podocytes. PMID: 28336924
  2. reticulon-1 is responsible for reduced chemotaxis of macrophages differentiated from the one bone marrow of ultraviolet-irradiated and ultraviolet-chimeric mice PMID: 29167231
  3. RTN1A is a key mediator for proteinuria-induced tubular cell toxicity and renal fibrosis. PMID: 26739891
  4. RTN1A contributes to progression of kidney disease by inducing ER stress. PMID: 26227493
  5. RTN-1C is able to specifically regulate gene expression, modulating transcript clusters which have been implicated in the onset of neurodegenerative disorders PMID: 20708685

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Subcellular Location Endoplasmic reticulum membrane, Multi-pass membrane protein
Database Links

KEGG: mmu:104001

STRING: 10090.ENSMUSP00000077594

UniGene: Mm.221275

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