Recombinant Mouse Reticulon-4 (Rtn4), partial

1. Nogo-A and NgR1 interactions may contribute to axonal branching in lateral olfactory tract development PMID: 28000762
2. NOGO-B/RTN4B and NOGO-A/RTN4A are simultaneously expressed in cultured epithelial, fibroblast and neuronal cells. Morphological analysis of cells with manipulated levels of NOGO-B/RTN4B revealed that it is required for maintenance of normal endoplasmic reticulum shape. PMID: 27786289
3. The results of this study showed the Nogo-B is expressed in the floor plate of mouse embryo, which probably mediates axon crossing in the spinal cord by repelling axons out of the midline when they start upregulate NgR. PMID: 28543060
4. induction of hepatic NgBR expression by atorvastatin mainly depended on inactivation of extracellular signal-regulated kinases 1/2 (ERK1/2) and protein kinase B (Akt). Taken together, our study demonstrates that statins inhibit NAFLD mainly through activation of NgBR expression. PMID: 29217477
5. We show here that Nogo-A is highly expressed not only in excitatory, but also in inhibitory, Parvalbumin positive neurons in the adult hippocampus. By this means our current and previous data indicate that Nogo-A loss-of-function positively influences spatial learning by priming the neuronal structure to a higher plasticity level. PMID: 27349794
6. Nogo-A signaling in the adult nervous system modulates the spine actin cytoskeleton within minutes to control structural plasticity at dendritic spines of CA3 pyramidal neurons. Acute Nogo-A loss-of-function transiently increases F-actin stability and results in an increase in dendritic spine density and length. Nogo-A acutely restricts AMPAR insertion and membrane potential amplitude at hippocampal synaptic sites. PMID: 26748478
7. deregulation of Nogo-C by miRNA may be a potential therapeutic target for ischemia-related heart diseases. PMID: 27763637
8. stimulated angiogenesis upon Nogo-A gene deletion results in the insertion of complete capillary micro-networks and not just single vessels into existing vascular networks. PMID: 27927704
9. The increase of Nogo-A expression can selectively influence the distribution of inwardly rectifying potassium channel 4.1 in glia but is not essential for inwardly rectifying potassium channel 4.1-mediated potassium conductance at the plasma membrane in physiological conditions. PMID: 27276652
10. Nogo-A restricts visual experience-driven plasticity of the optokinetic response and plays a role in the segregation and maintenance of retinal projections to the brain. PMID: 25284126
11. The Ad-Nogo-B-treated mice also had less severe lung injury, less alveolar protein exudation, and a higher number of macrophages but less neutrophil infiltration compared with Ad-RFP-treated mice. PMID: 26174362
12. Nogo knockdown (KD) in non-transformed and Ras-transformed cells both enhanced virus-induced IFN response, suggesting that both cleaved and uncleaved Nogo can suppress IFN response. PMID: 25946643
13. the Nogo/NgR signal might be involved in multiple processes in various inflammation-associated CNS diseases. PMID: 26472924
14. identifies Nogo-B as a key inhibitor of local sphingolipid synthesis PMID: 26301690
15. The findings indicate a critical role of Nogo-B and GRAMD4 in trafficking of TLR9. PMID: 25917084
16. Epithelial RTN-4B/NOGO-B was downregulated in human and experimental inflammatory bowel disease PMID: 25907690
17. study represents the first side-by-side comparison between PTEN deletion and Nogo deletion on Corticospinal tract regeneration and sprouting. PMID: 25904793
18. the downregulation of Nogo-A protein might have a role in the altered synaptic plasticity during aging. PMID: 25078756
19. Nogo receptor inhibition enhances functional recovery following lysolecithin-induced demyelination in mouse optic chiasm. PMID: 25184636
20. The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling. PMID: 24278366
21. These results indicate that during maturation of cultured midbrain (dopaminergic) neurons, intracellular Nogo-A supports neurite growth initiation and branch formation. PMID: 24157929
22. The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. PMID: 24453941
23. a direct correlation between ER morphology and SOCE and highlight the importance of RTN4 in cellular Ca(2+) homeostasis PMID: 24558039
24. the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation. PMID: 24129566
25. Nogo-A is closely involved in the neuronal response to hypoxic and oxidative stress. PMID: 23909438
26. These findings identify Nogo-A as an important negative regulator of developmental angiogenesis in the CNS. PMID: 23625008
27. The absence of Nogo-B enhances apoptosis of hepatic stellate cells in experimental cirrhosis. PMID: 23313137
28. Reticulon 4B (Nogo-B) facilitates hepatocyte proliferation and liver regeneration in mice. PMID: 23299899
29. Data from knockout/diabetic mice suggest that down-regulation of Nogo-A up-regulates insulin secretion in beta cells and improves glucose clearance; Nogo-A is expressed in pancreatic islets and is involved in exocrine function/glucose homeostasis. PMID: 23274909
30. findings reveal a new function for Nogo-A and NgR1 in the homeostatic regulation of the pace of neurogenesis and neuroblast migration. PMID: 23223298
31. Nogo-A appears as a negative regulator of Purkinje cell (PC) input synapses, which orchestrates cerebellar connectivity through regulation of synapse morphology and the size of the PC dendritic tree. PMID: 23277570
32. Noga-A and Nogo receptor are actively regulated in experimental autoimmune encephalomyelitis (EAE) lesions, indicating a specific time window for localized axonal regeneration in the acute phase of EAE. PMID: 22964785
33. Nogo-A overexpression in RGCs in vivo or in the neuronal cell line F11 in vitro promoted regeneration, demonstrating a positive, cell-autonomous role for neuronal Nogo-A in the modulation of axonal regeneration. PMID: 22193546
34. Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination in the developing central nervous system. PMID: 22160722
35. increased Nogo-A expression and ultrastructural changes of the endoplasmic reticulum PMID: 21980529
36. Data showd that Nogo-B, a regulator of ER structure, was induced by hypoxia in pulonary artery smooht muscle cells but not the systemic vasculature through activation of the ER stress-sensitive transcription factor ATF6. PMID: 21697531
37. a novel mechanism by which PIR-B-mediated regulation is achieved differentially but competitively via MHCI and Nogo in cells of the immune system PMID: 21636572
38. A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1. PMID: 21454605
39. Nogo-B regulates liver fibrosis, at least in part, by facilitating the TGFbeta/Smad2 signaling pathway in myofibroblasts. PMID: 21480333
40. Endogenous Nogo-B, which may exert its effects through ARPC 2/3 and MYL-9, is necessary for the migration and contraction of airway smooth muscle cells. PMID: 21251247
41. NogoA could thus serve as an important negative regulator of functional and structural plasticity in mature neuronal networks. PMID: 21262805
42. use 2 models of inflammation to show that endothelial Nogo-B regulates leukocyte transmigration and intercellular adhesion molecule-1 (ICAM-1)-dependent signaling PMID: 21183689
43. These results suggest a role for neuronal Nogo-A in maintaining a spine phenotype in neocortical pyramidal cells. PMID: 20938157
44. Nogo-mediated inhibition of neuritic sprouting contributes to the disease progression in an APP transgenic model of Alzheimer's disease in a way that is mechanistically distinct from what has been proposed for Rtn3 or NgR. PMID: 20433905
45. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. PMID: 20975041
46. This study suggested that Nogo-A and its receptor complex play a role in the interplay of adhesive and repulsive cell interactions in radial migration during cortical development. PMID: 20093372
47. In a study of in vitro slice cultures of neonatal hippocampus, Nogo-A plays a major role in stabilizing and maintaining the architecture of pyramidal neurons. PMID: 20926648
48. Nogo-A is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching PMID: 20573699
49. Data show the increased expression of Nogo-A mRNA and Nogo-A protein in brain tissue of neonatal mice with ischemic-hypoxic brain damage. PMID: 17229389
50. While Nogo may modulate axon sprouting, it does not play a major role in central nervous system axon regeneration failure. PMID: 20547125

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KEGG: mmu:68585

STRING: 10090.ENSMUSP00000099907

UniGene: Mm.192580