Recombinant Mouse Retinoblastoma-associated protein (Rb1), partial

1. The Rb1 tumor suppressor gene modifies telomeric chromatin architecture by regulating TERRA expression. PMID: 28169375
2. These findings demonstrate that developmental stage-specific as well as species- and cell type-specific features sensitize to RB1 inactivation and reveal the human cone precursors' capacity to model retinoblastoma initiation, proliferation, premalignant arrest, and tumor growth. PMID: 30213853
3. Thus, Lin37 is an essential component of DREAM complex that cooperates with Rb to induce quiescence. PMID: 28920576
4. Results show that ablation of the three members of the retinoblastoma family (RB1, p107 and p130) which targets a variety of adult lung epithelial cells, leads to spontaneous velopment of tumorlets, benign precancerous neuroendocrine (NE) lesions that do not progress to malignant tumors. Data imply the requirement of other oncogenic signaling pathways for full transformation in NE lung lesions mutant for the Rb family. PMID: 27966456
5. studies demonstrate that pRb loss in the Tie2-lineage that includes aortic valve interstitial cells is sufficient to cause age-dependent aortic valve dysfunction PMID: 29304157
6. These results demonstrate a crucial role for RB in the generation and the survival of DGCs in the embryonic and the adult brain. PMID: 27325572
7. Rb selectively inhibits innate IFN-beta production by enhancing deacetylation of Ifnb1 promoter, exhibiting a previous unknown non-classical role in innate immunity, which also suggests a role of Rb in the regulation of type I IFN production in inflammatory or autoimmune diseases. PMID: 27267461
8. Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice. PMID: 28343662
9. Findings indicate that inactivation of the Rb family proteins (Rb, p107, and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 protein (Socs3) expression in triple knockout (TKO) HSCs. PMID: 28550162
10. Combined deletion of Vhl, Trp53 and Rb1 specifically in renal epithelial cells in mice caused clear cell renal cell carcinoma. PMID: 28553932
11. The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 to diverse repeat sequences. PMID: 27889452
12. The N-Terminal phosphorylation of RB by p38 bypasses its inactivation by cyclin-dependent kinases and prevents proliferation in cancer cells. PMID: 27642049
13. Inhibition of Rb phosphorylation by depleting cyclin D or using CDK4/6 inhibitors releases Rb-mediated mTORC2 suppression. This, in turn, leads to elevated Akt activation to confer resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt inhibitors. PMID: 27237051
14. The data presented here support a hypothesis in which RB1 and TP53 loss in prostate cancer derepresses Ezh2 and Sox2 factors, creating a stem cell-like epigenetic environment permissive for lineage plasticity PMID: 28059767
15. Findings reveal that Rb deficiency accelerated urinary bladder cancer progression, exposing an important role of Rb in suppressing urinary bladder cancer for treatment in the future. PMID: 28259945
16. systems-level control of cell cycle arrest by pRB-E2F and p27-CDK regulation, is reported. PMID: 27821477
17. RB is necessary for the recruitment of the BRG1 ATPase to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination PMID: 27940962
18. Findings implicate Rb1 in the regulation of the THO ribonucleoprotein complex. PMID: 27001308
19. contribution of these precursors to the Rb(+/-) adipose phenotype is driven, at least in part, by interaction with BMP7 pathway PMID: 26727985
20. Identify Dyrk1a as a novel negative regulator of D-cyclin-mediated Rb1/E2f-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy. PMID: 27056896
21. These findings establish that Rb1 and Skp2 deletions are synthetic lethal and suggest how this lethal relationship might be circumvented, which could help design better therapies for pRb-deficient cancer. PMID: 26966181
22. Results indicate that Rb and p53 not only function as tumor suppressors in response to carcinogenic injury, but also in response to non-carcinogenic injury. PMID: 26967735
23. Suggest that a principal role for RB1 in development is coordinating the events required for terminal differentiation of erythroid cells. PMID: 26397180
24. data also suggest that Rb1 loss is not sufficient to transform post-germinal center B cells and that additional, specific mutations are likely required to cooperate with Rb1 loss to induce malignant transformation. PMID: 26607597
25. Data (including data from studies in knockout/transgenic mice) suggest CDKN1B-RB1-E2F1 (cyclin-dependent kinase inhibitor 1B-RB1-E2F transcription 1) pathway is essential for SSC (spermatogonial stem cell) self-renewal/protection against DNA damage. PMID: 25959802
26. A model suited to determine the cellular function of the alternative Rb1 transcript. PMID: 26275142
27. we have discovered a novel role of Rb1 in regulating the entry of primordial oocytes into the pool of growing follicles and signaling between the oocyte and granulosa cells during the protracted process of oocyte growth PMID: 26176933
28. Data show that the p16/CDKN2A-cyclin-dependent kinase 4 (CDK4)-RB1 protein pathway is frequently disrupted in fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP). PMID: 25852058
29. the genetic interaction between Rb and p53 is a critical determinant of the undifferentiated state in normal and tumor cells. PMID: 25694388
30. silencing of Rb enhances mitochondrial oxidative metabolism and fatty acid and glucose disposal in skeletal myotubes PMID: 26241807
31. Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer. PMID: 25745996
32. The functions of Rb in modulating cell proliferation, death and transformation are mediated by its controlling cellular redox state. PMID: 25019272
33. Deletion of Rb or p130 leads to impaired repression of Sox2, a defect amplified by inactivation of p53. Identify binding of pRb and p130 to an enhancer with crucial regulatory activity on Sox2 expression. PMID: 25576924
34. protein changes induced by Rb loss are coupled with proliferation but uncoupled from transcription. PMID: 26314710
35. Knockdown or deletion of Rb1 enhanced adult nerve regeneration after both crush and transection injuries. Plasticity is achieved in part through upregulation of neuronal PPARg. PMID: 24752312
36. These studies therefore identify Rb as a global transcriptional repressor of pluripotency networks. PMID: 25467916
37. Cyclin D has a role in activating the Rb tumor suppressor by mono-phosphorylation PMID: 24876129
38. We found a central role of Rb in the dual effects of GLP-1 in alpha and beta cells. Our findings highlight unique contributions of individual Rb family members to islet cell proliferation and survival. PMID: 25249236
39. Our data show that Rb1 mRNA is expressed in both dental epithelial and dental mesenchymal progenitor cells. In addition, Rb1 mRNA appears upregulated in differentiating ameloblasts and odontoblasts, suggesting roles for Rb1 in tooth differentiation. PMID: 22300525
40. RESULTS: A common Rb1 allele derived from the BALB/cHeNhg strain was identified as the major determinant of radiation-induced osteosarcoma risk at this locus. PMID: 25092376
41. Retinoblastoma protein potentiates the innate immune response in hepatocytes. PMID: 24824777
42. Data show that phosphorylation of p27Kip1 threonine 187 (p27T187) is important in retinoblastoma protein Rb1-deficient tumorigenesis and immunity in aging. PMID: 25583987
43. These results point to RB as a key regulator of SC function in adult mice and that the RB/E2F3 pathway directs SC maturation, cell cycle quiescence, and RB protects SC from apoptosis. PMID: 24901045
44. The prolonged half-life of retinoblastoma 1 mRNA level secures the protein level of retinoblastoma, which facilitates cell cycle arrest of neurons in the process of ischemia/reperfusion treated with berberine. PMID: 24603897
45. These data demonstrate the context specificity of RB and the key role RB plays in the suppression of hepatocellular carcinoma driven by xenobiotic stress. PMID: 24726645
46. showed that the D326V missense pRb bound to E2F1 but failed to interact with E2F2/3 PMID: 25088905
47. p21, in conjunction with pRb, has a central role in regulating multiple epithelial processes and orchestrating specific tumor suppressor functions PMID: 24121270
48. Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor target genes and allows pRb activity to be effectively integrated with the DNA damage response. PMID: 25049398
49. In Rb1-deficient pituitary tumorigenesis, Skp2 deletion or p27T187A mutation converts E2F1's role from proliferative to apoptotic. PMID: 24632684
50. Rb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner. PMID: 24324613

Show More

Hide All

KEGG: mmu:19645

STRING: 10090.ENSMUSP00000022701

UniGene: Mm.273862