Retinoblastoma-associated protein is a protein in humans that is encoded by RB1 gene. Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1.
The following RB1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
RB1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA019386GA01HU | RB1 Antibody |
Human,Mouse | ELISA,WB,IHC |
CSB-PA201739 | Phospho-RB1 (Ser795) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA193785 | Phospho-RB1 (Ser807) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA133410 | Phospho-RB1 (Ser780) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA990932 | RB1 (Ab-795) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA445358 | RB1 (Ab-807) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA095986 | RB1 (Ab-780) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA582717 | Phospho-RB1 (Ser608) Antibody |
Human,Mouse | ELISA,WB,IHC |
CSB-PA036254 | RB1 (Ab-608) Antibody |
Human,Mouse | ELISA,WB |
CSB-PA237047 | Phospho-RB1 (Thr826) Antibody |
Human,Mouse,Rat | ELISA,WB,IF |
CSB-PA019386ESR2HU | RB1 Antibody |
Human | ELISA, IHC |
CSB-PA000616 | Phospho-RB1 (S780) Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA000617 | Phospho-RB1 (S807) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA003947 | RB1 Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA003948 | RB1 Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA040164 | Phospho-RB1 (S795) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA040165 | Phospho-RB1 (S811) Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA040166 | Phospho-RB1 (T826) Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA040167 | Phospho-RB1 (S608) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA040168 | Phospho-RB1 (S612) Antibody |
Human | IHC, ELISA |
CSB-PA040169 | Phospho-RB1 (S788) Antibody |
Human,Mouse,Rat | IHC, ELISA |
CSB-PA040170 | Phospho-RB1 (T821) Antibody |
Human,Mouse,Rat | IHC, IF, ELISA |
CSB-PA040171 | Phospho-RB1 (S249) Antibody |
Human,Mouse,Rat | IF, ELISA |
CSB-PA040172 | RB1 Antibody |
Human,Mouse,Rat | IHC, IF, ELISA |
CSB-PA040173 | RB1 Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA040174 | RB1 Antibody |
Human,Mouse,Rat | IHC, IF, ELISA |
CSB-PA040176 | RB1 Antibody |
Human,Mouse,Rat | IHC, IF, ELISA |
CSB-PA040177 | RB1 Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA232358 | RB1 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-RA019386A807phHU | Phospho-RB1 (S807) Recombinant Monoclonal Antibody |
Human | ELISA, IF |
CSB-RA019386A780phHU | Phospho-RB1 (S780) Recombinant Monoclonal Antibody |
Human | ELISA, IHC, IF, IP |
RB1 Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA155294ZA01RA | Rb1 Antibody |
Rattus norvegicus | ELISA, WB (ensure identification of antigen) |
RB1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP019386MO CSB-EP019386MO CSB-BP019386MO CSB-MP019386MO CSB-EP019386MO-B |
Recombinant Mouse Retinoblastoma-associated protein (Rb1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RB1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP019386RA CSB-EP019386RA CSB-BP019386RA CSB-MP019386RA CSB-EP019386RA-B |
Recombinant Rat Retinoblastoma-associated protein (Rb1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-RP155294r(A3) | Recombinant Rat Retinoblastoma-associated protein (Rb1), partial |
E.coli |
RB1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP019386HU CSB-EP019386HU CSB-BP019386HU CSB-MP019386HU CSB-EP019386HU-B |
Recombinant Human Retinoblastoma-associated protein (RB1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RB1 Proteins for Cocos nucifera (Coconut palm)
Code | Product Name | Source |
---|---|---|
CSB-YP814119CMW CSB-EP814119CMW CSB-BP814119CMW CSB-MP814119CMW CSB-EP814119CMW-B |
Recombinant Cocos nucifera Retinoblastoma-related protein (Rb1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RB1 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP856183CH CSB-EP856183CH CSB-BP856183CH CSB-MP856183CH CSB-EP856183CH-B |
Recombinant Chicken Retinoblastoma-associated protein (RB1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RB1 Proteins for Nicotiana tabacum (Common tobacco)
Code | Product Name | Source |
---|---|---|
CSB-YP871200NHE CSB-EP871200NHE CSB-BP871200NHE CSB-MP871200NHE CSB-EP871200NHE-B |
Recombinant Nicotiana tabacum Retinoblastoma-related protein 1 (RB1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |