Recombinant Mouse Rho GDP-dissociation inhibitor 2 (Arhgdib)

Code CSB-YP717218MO
MSDS
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Source Yeast
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Code CSB-EP717218MO
MSDS
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Source E.coli
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Code CSB-EP717218MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP717218MO
MSDS
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Source Baculovirus
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Code CSB-MP717218MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Arhgdib
Uniprot No.
Alternative Names
Arhgdib; Gdid4Rho GDP-dissociation inhibitor 2; Rho GDI 2; D4; Rho-GDI beta
Species
Mus musculus (Mouse)
Expression Region
2-200
Target Protein Sequence
TEKDAQPQL EEADDDLDSK LNYKPPPQKS LKELQEMDKD DESLTKYKKT LLGDVPVVAD PTVPNVTVTR LSLVCDSAPG PITMDLTGDL EALKKDTFVL KEGIEYRVKI NFKVNKDIVS GLKYVQHTYR TGMRVDKATF MVGSYGPRPE EYEFLTPVEE APKGMLARGT YHNKSFFTDD DKQDHLTWEW NLAIKKDWTE
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members.
Gene References into Functions
  1. Ly-GDI is a critical regulator of inflammatory injury after deposition of IgG immune complexes and that it negatively regulates the lung NF-kappaB activity. PMID: 26469087
  2. these results indicate that RhoGDIbeta functions as a novel BMP4 signaling target that regulates adipogenesis and myogensis. PMID: 25778399
  3. Rictor regulates cell migration by suppressing RhoGDI2. PMID: 22777355
  4. Raptor siRNA suppressed the effects of GM3 on Ly-GDI expression and Akt phosphorylation at Thr(308) , suggesting GM3 signals to be transduced to mTOR-Raptor and Akt-Thr(308) , leading to Ly-GDI stimulation PMID: 21518140
  5. Impaired interaction of RhoGDIbeta with Rac1 isoprenyl groups possibly makes RhoGDIbeta function as a positive regulator for Rac1 during metastasis. PMID: 17049467
  6. Rho GDIalpha and Rho GDIbeta play synergistic roles in lymphocyte migration and development by modulating activation cycle of the Rho proteins in a lymphoid organ-specific manner. PMID: 17142749

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Subcellular Location
Cytoplasm, cytosol.
Protein Families
Rho GDI family
Tissue Specificity
Preferentially expressed in hematopoietic cells.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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