Recombinant Mouse Ribosomal protein S6 kinase alpha-5 (Rps6ka5), partial

1. These data suggest that the kinase activity of MSK1 is not directly required for several forms of synaptic plasticity or spatial learning and memory. PMID: 28275711
2. These data of this study provided important new insights into the mechanism by which the MAPK/MSK1 signaling cassette confers neuroprotection against excitotoxic insults. PMID: 28870089
3. Data suggest that expression of Rps6ka5 in gonadotroph cell line is up-regulated by GnRH signaling and is required for Cga expression; GnRH-activates Rps6ka5 targets at the first nucleosome just downstream from the transcriptional start site. (Rps6ka5= mitogen and stress-activated protein kinase 1; GnRH = gonadotropin-releasing hormone; Cga = gonadotropin alpha subunit) PMID: 29054929
4. chromatin modifier, MSK1/2, has a role in suppressing endocrine and promoting acinar differentiation during pancreatic development PMID: 27973548
5. abnormal regulation of MSK1 contributes to the development of L-DOPA-induced dyskinesia and to the concomitant increase in striatal FosB, which may occur via increased histone H3 phosphorylation at the fosB promoter PMID: 25193242
6. Accelerated apoptotic death and in vivo turnover of erythrocytes have been found in mice lacking functional MSK1/MSK2. PMID: 26611568
7. Results suggest that MSK1/2 plays a significant role in the regulation of ischemia-induced progenitor cell proliferation and neurogenesis PMID: 25451279
8. MSK1 has a role in malignant transformation and skin cancer development, but is inhibited by chrysin derivative 69407 PMID: 24169959
9. the impact of MSK1 on glucocorticoid receptor-mediated transactivation PMID: 23831393
10. MSK1 is an important novel molecule involved in RANKL signaling and osteoclast differentiation PMID: 23619911
11. MSK1/2 knockout results in reduced IL-10 secretion. PMID: 23382072
12. MSK1-deficient mice exhibit a decreased capacity to entrain to a new light cycle, attenuated Period1 expression, histone phosporylation and CREB phosphorylation. PMID: 23127194
13. these data reveal that MSK1 serves as a critical regulator of hippocampal physiology and function PMID: 23077336
14. data reveal a critical role for MSK1/2 as regulators of both basal and activity-dependent progenitor cell proliferation and morphological maturation in the subgranular zone PMID: 23020821
15. This study demonstrated that MSK1 is an integral part of a signaling pathway that underlies the adaptive response to synaptic and environmental experience. PMID: 22993422
16. by suppression of both NF-kappaB and ERK1/2-MSK1 signaling, DMF inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation. PMID: 22733812
17. MSK1 is an important downstream kinase involved in CS-induced NF-kappaB activation PMID: 22312446
18. the signaling pathways of MAPK, MSK1, and NF-kappaB play important roles in thrombin-induced iNOS expression in alveolar macrophages PMID: 22004609
19. Comparison of the effects of SB-747651A, both in vitro and in cells, demonstrated that SB-747651A exhibited improved selectivity over H89 and Ro 31-8220 and therefore represents a useful tool to study MSK function in cells. PMID: 21970321
20. phosphorylation was required for up-regulation of the EMI2 activity in the oocytes. These results suggest that mouse MSK1 may play a key role in the metaphase-II arrest through phosphorylation of EMI2 PMID: 21924255
21. MSK1/2 are involved in the activation of feedback mechanisms that dampen oxazolone-induced skin inflammation. PMID: 21166721
22. MSK1 represents a pro-survival pathway bifurcating downstream of p38 and antagonizes the established pro-apoptotic p38 MAPK function. PMID: 21106525
23. These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis. PMID: 21314333
24. mechanism of immediate-early gene induction PMID: 21071437
25. MSK1/2 regulate pri-miR-212/132 transcription via the phosphorylation of CREB. PMID: 20307261
26. MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages PMID: 19922413
27. Mycobacterium avium-induced cyclooxygenase-2 expression in mouse macrophages is regulated by TLR-2 and MSK1 PMID: 15496409
28. findings suggested that MSK1/2 might play a critical role in the survival of lipopolysaccharide-stimulated RAW 264.7 cells PMID: 15681159
29. MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation PMID: 16517600
30. MSK1 is the critical mediator of differentiation-induced H3 phosphoacetylation PMID: 16728397
31. MSK1 has a role downstream of p38 in the regulation of As2O3 responses PMID: 16762916
32. Erk activation leads to phosphorylation of the progesterone receptor (PR), activation of Msk1, and recruitment of a complex of the three proteins to a nucleosome on the MMTV promoter. PMID: 17081988
33. We conclude that adenylyl cyclase activity supports the activation of MAPK, and that MSK1 is the major CREB kinase activated during training for contextual memory. PMID: 17196532
34. correlated to a reduction in the T-Cell Receptor-induced up-regulation of the IL-2 receptor CD25 and a requirement for MSK in IL-2-induced CREB phosphorylation PMID: 17668895
35. Our study identifies MSK1 as an important regulator of chromatin remodeling in long-term memory. PMID: 18003853
36. mitogen- and stress-activated kinase-1(MSK-1) deficiency is involved in transcriptional dysregulation and striatal degeneration PMID: 18029446
37. the action of 1,25(OH)(2)D(3) on colon carcinoma cells depends on the dual action of VDR as a transcription factor and a nongenomic activator of RhoA-ROCK and p38MAPK-MSK1. PMID: 19015318
38. The authors demonstrate that MSK1 phosphorylates RARalpha at S369 located in the ligand-binding domain, allowing the binding of TFIIH and thereby phosphorylation of the N-terminal domain at S77 by cdk7/cyclin H. PMID: 19078967

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KEGG: mmu:73086

STRING: 10090.ENSMUSP00000042987

UniGene: Mm.220417