Recombinant Mouse SH2B adapter protein 1 (Sh2b1)

1. Brain-specific Sh2b1 knockout (KO) mice exhibited brain growth retardation and reactive aggression. PMID: 29180441
2. data identify SH2B1 as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 as a major regulator of proliferation and survival of beta-cells. PMID: 27217487
3. that SH2B1 is a key positive mediator of pathological cardiac hypertrophy PMID: 26077624
4. SH2B1 in pancreatic beta-cells promotes insulin synthesis and secretion at least in part by enhancing activation of JAK2 and/or Pdx1 pathways in response to hormonal and nutritional signals. PMID: 24645678
5. hepatic SH2B1 is not required for the maintenance of normal insulin sensitivity and glucose metabolism; however, it regulates liver triacylglycerol synthesis, lipolysis, and VLDL secretion. PMID: 24358267
6. These data indicate that SH2B1 in beta-cells is an important prosurvival and proproliferative protein and promotes compensatory beta-cell expansion in the insulin-resistant state and in response to beta-cell stress. PMID: 24150605
7. Results suggest that SH2B1beta enhances GH-stimulated macrophage motility via mechanisms involving phosphorylation of SH2B1beta on tyrosines 439 and 494 and movement of SH2B1beta out of the plasma membran. PMID: 23444381
8. SH2B1 is responsive to erythropoietin stimulation and becomes phosphorylated PMID: 22669948
9. serves as a focal adhesion protein that regulates focal adhesion size and number PMID: 21878491
10. Leptin-stimulated activation of hypothalamic JAK2 and phosphorylation of hyphothalamic IRS2 were significantly impaired in SH2B1(-/-) mice. PMID: 20360640
11. Mutations in the SH2 domain of SH2B1 may increase the susceptibility to obesity and type 2 diabetes in a dominant-negative manner. PMID: 20484460
12. Genetic deletion of SH2B1 also resulted in growth retardation, obesity, and type 2 diabetes in mice; surprisingly, life span and oxidative resistance were reduced in SH2B1 null mice. PMID: 20417156
13. These results suggest that SH2-Bbeta regulation of Akt partly participates in the NGF-mediated development of allergic airway challenge. PMID: 19947990
14. These results suggest that 1) SH2-B beta specifically activates JAK2, 2) APS negatively regulates both JAK2 and JAK1, and 3) both SH2-B beta and APS may serve as adapter proteins for all three JAKs independent of any role they have in JAK activity. PMID: 11751854
15. Lnk, SH2-B, and APS have roles in mast cell development, growth, and functions PMID: 14766215
16. Data suggest that SH2-B is a physiological enhancer of insulin receptor activation and is required for maintaining normal insulin sensitivity and glucose homeostasis during aging. PMID: 15314154
17. regulates the activity of a variety of transporters under normal and pathological conditions PMID: 16024787
18. Data suggest that SH2-B is an endogenous enhancer of leptin sensitivity and required for maintaining normal energy metabolism and body weight in mice. PMID: 16098827
19. SH2-B, but not APS, is a key positive regulator of energy and glucose metabolism in mice PMID: 16455776
20. neuronal SH2B1 regulates energy balance, body weight, peripheral insulin sensitivity, and glucose homeostasis at least in part by enhancing hypothalamic leptin sensitivity PMID: 17235396
21. SH2-Bbeta enhances actin-based movement of Listeria monocytogenes provided VASP is present. PMID: 17452473
22. an essential role of the SH2B1 variants in the activation of the Src kinase and the resulting mitogenic response--extending to phenotypic cell transformation and involving the established Src substrate STAT3 PMID: 18247337
23. SH2B1 is an endogenous insulin sensitizer; it directly binds to insulin receptors, IRS-1 and IRS-2, and enhances insulin sensitivity PMID: 19542202

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KEGG: mmu:20399

STRING: 10090.ENSMUSP00000032978

UniGene: Mm.8538