Product Details

Purity

>85% (SDS-PAGE)

Target Names

Shank1

Uniprot No.

D3YZU1

Alternative Names

Shank1; SH3 and multiple ankyrin repeat domains protein 1; Shank1

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.

Gene References into Functions

A review: Shank1 knockout mouse model for autism spectrum disorder (ASD) displays moderate impairments in (I) social behavior, (II) communication, and (III) repetitive and stereotyped patterns of behavior, together with (IV) aberrant cognitive phenotypes, consistent with the symptoms present in humans diagnosed with ASD and carrying SHANK1 deletions. PMID: 28963042
Study demonstrates that SHANK1 is developmentally expressed in hippocampal neurons and glial cells. Although the specific role for this developmental expression pattern in these different cell types is not fully understood, the current study provides the first developmental cell-type-specific expression profile. PMID: 29218848
Expression of SHANK genes is a key component of autism spectrum disorder-associated pathways as the protein products are enriched in the postsynaptic density (PSD) of glutamatergic neurons. PMID: 26419918
The findings of this study indicated that Shank1 deletions lead to an aberrant cognitive phenotype characterized by severe impairments in object recognition memory and increased hippocampal BDNF levels, possibly due to epigenetic modifications. PMID: 28500650
reduction of PV(+) neurons was in all cases, i.e., in PV+/-, Shank1-/- and Shank3B-/- mice, was due to a reduction in Pvalb mRNA and PV protein PMID: 26819149
Results suggest that Shank1 scaffold in PV+ interneurons regulates excitatory synaptic strength and participates in the maintenance of excitatory and inhibitory balance in excitatory neurons. PMID: 25816842
Deletion of Shank1 has minimal effects on the molecular composition and function of glutamatergic afferent postsynapses in the mouse inner ear. PMID: 25637745
This study demonistrated that Shank1+/- heterozygous and to a lesser extent Shank1-/- null mutant mice displayed slightly elevated levels of self-grooming behavior as adults, but not as juveniles. PMID: 24820912
These findings provide convincing evidence for Shank 1A expression in both the inner and outer plexiform layers, and indicate a potential role for PSD-95/Shank 1 complexes at cone synapses in the outer retina. PMID: 22984429
Shank1 null mice do not demonstrate autism-relevant social interaction deficits, but confirm and extend a role for Shank1 in motor functions. PMID: 20868654
The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism. PMID: 21695253
These results affirm the importance of Shank1 for synapse structure and function in vivo, and they highlight a differential role for Shank1 in specific cognitive processes. PMID: 18272690

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Subcellular Location

Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic density.

Protein Families

SHANK family

Tissue Specificity

In brain, highly expressed in cortex, hyppocampus and cerebellum.

Database Links

KEGG: mmu:243961

STRING: 10090.ENSMUSP00000103571

UniGene: Mm.360368

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Recombinant Mouse SH3 and multiple ankyrin repeat domains protein 1 (Shank1), partial

Product Details

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Target Background

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