Recombinant Mouse STIP1 homology and U box-containing protein 1 (Stub1)

1. MLL5 has a role in suppressing antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation PMID: 29593341
2. these findings suggest that CHIP plays a role in negative regulation of PINK1 stability and may suppress PINK1's cytoprotective effect during staurosporine-induced mammalian cell death. PMID: 29242192
3. Results identified a new role of CHIP in adipocyte differentiation. CHIP interacts with and mediates the ubiquitylation of PPARgamma , which results in negative effects on adipogenesis. PMID: 28059128
4. these results indicate that phosphorylation of CHIP at Ser20 by Cdk5 activation inhibits CHIP-mediated truncated apoptosis-inducing factor (tAIF) degradation, thereby contributing to tAIF-induced neuronal cell death following rotenone treatment PMID: 29111393
5. CHIP was as a master regulator of AQP2 degradation via HSP70 that has dual functions: (1) as chaperone for AQP2 and (2) as an anchoring protein for MDM2 E3 ligase, which is likely to be involved in AQP2 degradation. PMID: 29145196
6. ACR interacts with proteins that regulate the ubiquitin-proteasome system, predominantly with the E3 ubiquitin-protein ligases Stub1, which binds the NH2 terminus of the ACR, and CRL4(CRBN), which is formed by Cul4a/b, Ddb1, and Crbn, and interacts with the COOH terminus of the ACR via Crbn. PMID: 27325702
7. The chaperone protein Hsp70 was found to be important for CHIP and NUCB1 interaction as well as CHIP-mediated NUCB1 down-regulation. PMID: 27178152
8. CHIP is a negative regulator of RIPK1 and RIPK3, thus inhibiting necroptosis. PMID: 27099235
9. our study demonstrated that over-expressing miR-21 in UCBMSCs could improve neovascularization in Critical limb ischemia (CLI) through enhancing HIF-1alpha activity by targeting CHIP, which may hold great therapeutic promise in treating CLI PMID: 26841045
10. CHIP is an essential regulator of neuronal bioenergetics and redox tone. PMID: 25602369
11. Cbl-b, together with Stub1, ubiquitinate Foxp3, and regulate tTreg development. PMID: 25560411
12. CHIP regulates the levels of FMR1 as an E3 ubiquitin ligase in phosphorylation-dependent manner, suggesting that CHIP regulates FMR1-mediated translational repression by regulating the levels of FMR1. PMID: 25268320
13. The cardiac CHIP appears to play a role in regulating autophagy during the development of cardiac hypertrophy, possibly by its role in supporting Akt signalling, induced by voluntary running in vivo. PMID: 23553918
14. Ebp1 p42 isoform regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP. PMID: 24651434
15. CHIP as a novel causative gene for autosomal recessive cerebellar ataxia PMID: 24312598
16. regulation of IL-4 receptor signaling in lung inflammation PMID: 24251647
17. AMPK is the first identified physiological substrate for CHIP chaperone activity, establishing a link between cardiac proteolytic and metabolic pathways. PMID: 23863712
18. CHIP enhances the decreased levels of p53 protein and the expression of HIF-1alpha and VEGF, and the formation of capillary and arteriole after myocardial infarction. PMID: 23485987
19. CHIP and Hsp90 axis regulates ILK turnover in fibroblasts. PMID: 23612611
20. CHIP plays an important role in regulating Ang II-triggered hypertensive cardiac apoptosis, inflammation, and fibrosis. PMID: 22717542
21. evidence that CHIP binds, ubiquitinates and regulates expression of histone deacetylase 6 (HDAC6); demonstrated HDAC6 levels correlate with tau burden, while a decrease in HDAC6 activity or expression promotes tau clearance; evidence that loss of HDAC6 activity augments the efficacy of an Hsp90 inhibitor and drives degradation of tau PMID: 22492994
22. miR-764-5p positively regulates osteoblast differentiation from osteoblast progenitor cells by repressing the translation of CHIP protein PMID: 22407479
23. data indicate a clear subset of behaviors that are altered at baseline in CHIP deficient animals including wire hang, inverted screen, wire maneuver, and open field tasks PMID: 22606257
24. Study suggests that increases in CHIP observed after stroke like injuries are likely correlated with diminished survival and may negatively impact the neuroprotective potential of heat shock protein 70. PMID: 20677910
25. CHIP influences cellular senescence by modulating the oxidative load. PMID: 21510971
26. Data demonstrate rapid translocation of CHIP to the nucleus within minutes of heat stress and oxygen-glucose deprivation. PMID: 19953350
27. CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. PMID: 12150907
28. results demonstrate a novel co-chaperone(CHIP)-dependent mechanism through which eNOS trafficking is regulated and suggest a potentially generalized role for CHIP in protein trafficking through the Golgi compartment PMID: 14507928
29. CHIP (C-terminus of Hsp70-interacting protein) regulates activation of the stress-chaperone response through induced trimerization and transcriptional activation of HSF1 and is required for protection against stress-induced apoptosis in murine fibroblasts PMID: 14532117
30. Hsp70/CHIP may play an important role in the pathogenesis of tauopathies PMID: 14962978
31. CHIP is a ubiquitin ligase for four-repeat tau and maintains neuronal survival by regulating the quality control of tau in neurons PMID: 15447663
32. Data show that CHIP plays a crucial role in the ubiquitination and degradation of E2A proteins. PMID: 15456869
33. Data show that unliganded estrogen receptor alpha is ubiquitinated and degraded through a ubiquitin-proteasome pathway containing the carboxyl terminus of Hsc70-interacting protein (CHIP). PMID: 15538384
34. overexpression of CHIP suppresses the aggregation and cell death mediated by expanded polyglutamine proteins and the suppressive effect is more prominent when CHIP is overexpressed along with Hsc70. PMID: 15664989
35. CHIP is an E3 ligase that mediates alternative effects of the ubiquitin-proteasome pathway on glucocorticoid receptor down-regulation and transactivation PMID: 15761032
36. Increases in CHIP may protect against neurofibrillary tangles formation in the early stages of Alzheimer's disease. PMID: 16111477
37. CHIP not only enhances Hsp70 induction during acute stress but also mediates its turnover during the stress recovery process PMID: 16554822
38. Polyubiquitination of tau by CHIP may facilitate the formation of insoluble filamentous tau lesions. PMID: 16807328
39. These findings suggest that CHIP overexpression ameliorates SBMA phenotypes in mice by reducing nuclear-localized mutant AR via enhanced mutant AR degradation PMID: 17494697
40. Akt also prevents CHIP-induced tau ubiquitination and its subsequent degradation, either by regulating the Hsp90/CHIP complex directly or by competing as a client protein with tau for binding. Akt levels tightly regulate the expression of CHIP PMID: 18292230
41. impaired protein quality control contributes to cellular senescence and implicates CHIP-dependent quality control mechanisms in the regulation of mammalian longevity in vivo PMID: 18411298
42. Negative regulation of the Runx2 protein by CHIP is critical in the commitment of precursor cells to differentiate into the osteoblast lineage. PMID: 18541707
43. Function of deletion mutant shows that E3 ubiquitin ligases function redundantly. PMID: 18784277
44. study provides evidence that CHIP is a central component to the homeostatic mechanisms countering toxic polyQ proteins in the brain PMID: 19084066
45. CHIP plays an important role in regulation iNOS activity. PMID: 19362296
46. LRRK2 stability is regulated by the E3 ubiquitin ligase CHIP PMID: 19536328

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KEGG: mmu:56424

STRING: 10090.ENSMUSP00000040431

UniGene: Mm.277599