Recombinant Mouse Segment polarity protein dishevelled homolog DVL-2 (Dvl2)

1. Epsins are required for Dishevelled stability and Wnt signalling activation in colon cancer development. PMID: 25871009
2. Dpr1 promotes the ubiquitination of Dvl2 by pVHL and mediates the protein aggregate-elicited autophagy initiation PMID: 25825496
3. Dvl2 binds to Rab35 and activation is required for MCF-7 cell migration PMID: 23353182
4. Dvl-2 and Dvl-3 have a widespread distribution in both the olfactory epithelium and olfactory bulb PMID: 23437169
5. Dullard may play a role in the fine-tuning of WNT signalling activity by modulating the expression of ligands/antagonists and the availability of Dvl2 protein during specification of the germ cell lineage. PMID: 23469192
6. loss of Dvl2 function in Vangl2(Lp/+) embryos did not exacerbate the Vangl2(Lp/+) neuronal migration phenotype PMID: 22771245
7. Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway. PMID: 22609948
8. These findings suggest that Wnt5a-Ror-Dishevelled signaling constitutes a core noncanonical Wnt pathway that is conserved through evolution and is crucial during embryonic development. PMID: 22343533
9. Dvl2 has an inhibitory role in myogenesis and Stau1 coordinates myogenesis through the regulation of Dvl2 mRNA. PMID: 22166206
10. Dishevelled 2 co-precipitated with ephrin B2 and vice versa, suggesting an endogenous interaction between Dvl2 and ephrin B2 PMID: 21373749
11. In Nodal null embryos, membrane localisation of Dvl2 is reduced, while in mutants for the Nodal inhibitor Lefty1, Dvl2 is ectopically membrane localised, establishing a role for Nodal in modulating planar cell polarity signalling. PMID: 21364967
12. Data shsow that mutation of residues at the DEP-mu2 contact or in the tyrosine motif reduce affinity of Dvl2 for mu2. PMID: 20947020
13. Small intestines of Dvl2 mutants are shortened, reflecting in part a reduction of their crypt diameter and cell size. Results implicate Dvl2 and mTOR in the progression of colorectal neoplasia PMID: 20663899
14. Ror2/Fz7 receptor complex plays an important role in the Wnt5a/Rac1/AP-1 pathway by regulating the polymerization of Dvl. PMID: 20457807
15. Wnt3a stimulates Src docking to Dvl2 and activation of Src. PMID: 19920076
16. Dvl2 and Dvl3 proteins were found to be localized to the apical side of the node cells, and their location was polarized to the posterior side of the cells before the posterior positioning of the basal body. PMID: 20098415
17. Data show that that Frat synergizes with Diversin in the activation of JNK/AP-1 signaling. PMID: 19802005
18. DIX domain mediates targeting to actin stress fibres and cytoplasmic vesicles in vivo PMID: 12384700
19. Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure PMID: 12421720
20. has a predominant role in mediating Wnt-3a-dependent cell motility PMID: 15509575
21. Dvl2 mediates a conserved mammalian PCP pathway to regulate convergent extension during neurulation. PMID: 16571627
22. As embryos reach blastocyst stage, Dishevelled 2 becomes increasingly associated with cell membrane in trophectoderm cells, while at E4.5, Dishevelled 3 is highly enriched in the cytoplasm of inner cell mass cells. PMID: 17005174
23. The direct interaction of Dvl2 with AP-2 is important for Frizzled internalization and Frizzled/planar cell polarity signaling. PMID: 17199046
24. Wnt5a induces Dvl2 phosphorylation and dopaminergic differengtiation via a CK1-dependent mechanism. PMID: 17244647
25. Data report that targeted inactivation of BicC randomizes left-right asymmetry by disrupting the planar alignment of motile cilia required for cilia-driven fluid flow, and that BicC can uncouple Dvl2 signaling from the canonical Wnt pathway. PMID: 19666828

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KEGG: mmu:13543

STRING: 10090.ENSMUSP00000019362

UniGene: Mm.5114