Recombinant Mouse Serine/threonine-protein kinase PAK 2 (Pak2)

1. PAK2 acts as a Rac1-dependent negative regulator of neuronal glucose uptake and insulin sensitivity. PMID: 27040307
2. These results identify Pak1 and Pak2 as redundant regulators of myoblast differentiation in vitro and in vivo and as components of the promyogenic Ncad/Cdo/Cdc42 signaling pathway. PMID: 27920252
3. PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases. PMID: 28408623
4. Data indicate that resveratrol treatment inhibits neuronal glucose uptake via P21-activated kinase 2 (PAK2). PMID: 28216158
5. Mechanistic insights into the role of Pak2 in hematopoietic stem cells migration and homing. PMID: 26932803
6. Pak2 disruption decreased the survival and proliferation of multicytokine stimulated immature progenitors. PMID: 25586960
7. The data suggest that Pak2 controls thymic Natural Killer T-cell development by providing a signal that links Egr2 to induce PLZF, in part by regulating signaling lymphocyte activation molecule 6 expression. PMID: 26519537
8. In adult endothelial cells, Pak2 depletion leads to severe apoptosis and acute angiogenesis defects, and in adult mice, endothelial Pak2 deletion leads to increased vascular permeability. PMID: 26391956
9. Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance PMID: 26157175
10. Failure to induce proper actin cytoskeletal remodeling impaired PLCgamma1 and Erk1/2 signaling in the absence of Pak2, uncovering the critical function of Pak2 as an essential regulator that governs the actin cytoskeleton-dependent signaling PMID: 24843022
11. thrombin induces monocyte/macrophage migration via PAR1-Galpha12-dependent Pyk2-mediated Gab1 and p115 RhoGEF interactions, leading to Rac1- and RhoA-targeted Pak2 activation. PMID: 24025335
12. p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. PMID: 23335370
13. Pak2, but not Pak1, negatively regulates RhoA via phosphorylation of the guanine nucleotide exchange factor GEF-H1 at an inhibitory site, leading to increased GEF-H1 microtubule binding and loss of RhoA stimulation PMID: 23204526
14. Full-length PAK-2 rather than the caspase-activated PAK-2p34 is required for normal embryonic development. PMID: 21499899
15. phosphorylation of merlin at serine 518 is induced by the p21-activated kinase PAK2 PMID: 11782491
16. Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation PMID: 12853446
17. Pak2 has a role in the down-regulation of translation initiation in apoptosis by phosphorylation of Mnk1 PMID: 15234964
18. Rac1 and PAK2 activation that eventually controls the chemotactic response is regulated by Gi and PI3KGamma PMID: 15292195
19. Nef can activate murine PAK2 and associate with a small fraction of it, and may be required to induce a multiorgan AIDS-like disease in Tg mice PMID: 16407193
20. c-Abl represents a target downstream of phosphatidylinositol 3-kinase-activated PAK2, which differentiates TGF-beta signaling in fibroblasts and epithelial cell lines. PMID: 16867995
21. define a new class of PAK-interacting proteins, which play an important role in actin cytoskeletal reorganization PMID: 17543336
22. US3-mediated stress fiber disassembly requires PAK2, whereas US3-mediated cell projection formation mainly is mediated by PAK1, also indicating that PAK1 and PAK2 can have different biological effects on the organization of the actin cytoskeleton PMID: 19435845
23. Study showed that GKB induced apoptotic biochemical changes, including activation of JNK, caspase-3, and p21-activated protein kinase 2 (PAK2). PMID: 19723096

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KEGG: mmu:224105

STRING: 10090.ENSMUSP00000023467

UniGene: Mm.234204