Recombinant Mouse Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Ppp2r1a)

1. oocyte-specific deletion of Ppp2r1a led to severe female subfertility without affecting follicle survival, growth, and ovulation. PMID: 24899574
2. PP2A-A alpha transcriptional regulation is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1 PMID: 19750005
3. protein phosphatase 2A overexpression in NIH 3T3 cells PMID: 11665638
4. T-cell receptor (TCR)-dependent tyrosine phosphorylation may be the mechanism by which the regulatory subunit of PP2A prevents the inhibitory function of CTLA-4, before TCR-CTLA-4 coligation. PMID: 11994459
5. PP-2A regulation of paxillin phosphorylation may have a role in controlling tumor cell adherence and motility. PMID: 12198769
6. PP2A may contribute to melanoma cell radioresistance: the truncated isoform of the PP2A B56gamma regulatory subunit reduces irradiation-induced Mdm2 phosphorylation PMID: 15024700
7. PP2A has a fundamental role in cardiac function PMID: 15247211
8. response of endothelial cells to the tumor-derived motility-stimulatory factors PGE2/TGFbeta involved a decline in the activity of PP2A, a loss of PP2A co-precipitation with PTEN, and an increase in the PTEN serine phosphorylation level. PMID: 15516833
9. heat treatment inactivates PP2A, which may subsequently cause ERK activation and decreases melanin synthesis in melanocytes PMID: 15894174
10. Results indicate that polyamines regulate protein phosphatase 2A (PP2A)activity, and inhibition of PP2A in response to polyamine depletion increases levels of Bad and Bcl-2 proteins and prevents cytochrome c release, caspase-9, and caspase-3 activation. PMID: 15994315
11. Pim on PP2A activity may mediate the levels of c-Myc and the phosphorylation of proteins needed for increased protein synthesis, which could have a significant impact on tumor growth PMID: 16123140
12. PP2A plays a positive rather than a negative role in the regulation of IKKbeta PMID: 16126728
13. the carboxy-terminal leucine L309 of the PP2A catalytic subunit determines PP2A heterotrimer composition in vivo. PP2A subunit composition plays a crucial role in regulating cell adhesion and as a consequence in the development of the Harderian gland. PMID: 16679006
14. PP2A-mediated dephosphorylation of BCL-2 is required to protect BCL-2 from proteasome-dependent degradation, affecting resistance to ER stress PMID: 16717086
15. PP2A is involved in the post-transcriptional regulation of tumor necrosis factor-alpha. PMID: 17170118
16. Akt dephosphorylation was mediated by ceramide-induced PKCzeta-Akt association and PP2A activation in Leishmania donovani-infected macrophages. PMID: 17220321
17. Based on crystal structures of Galpha(12) and PP2A Aalpha, a model describing the binding surfaces and potential mechanisms of Galpha(12)-mediated PP2A activation is presented. PMID: 17303700
18. protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator is regulated by heptad repeats, which are targeted by HTLV-I tax PMID: 17314097
19. Suppression of PP-2A damages intracellular transport and leads to cell degeneration, and the memory deficits induced by suppression of the phosphatases. PMID: 17472709
20. Results describe the crystal structure of full-length SV40 small t antigen in complex with protein phosphatase 2A A subunit at 3.1 A resolution. PMID: 17608567
21. These results indicate a role for GSK-3beta in ceramide-induced apoptosis, in which GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 and caspase-8. PMID: 17666435
22. C3G triggers PP2A activation and binding to MEK and ERK at the subcortical actin cytoskeleton, thus favouring ERK dephosphorylation. PMID: 17825818
23. Polyoma small T uses PP2A to promote phosphorylation of Akt on both T308 & S473, resulting in a different pattern of phosphorylation of Akt substrates & shifting Akt from a proapoptotic to an antiapoptotic mode. PMID: 18006659
24. These data show that A(2A)R and A(1)R regulate PP2A activity, thus suggesting an important mechanism for modulating myocardial contractility. PMID: 18181173
25. PP2A is a physiologic phosphatase of FOXO1. PMID: 18211894
26. a role for the demethylated form of PP2A in maintenance of enzyme function and phosphorylation networks in vivo. PMID: 18596935
27. Nitration in PP2Ac is correlated with PP2A activation that mediates endothelial barrier dysfunction. PMID: 18791203
28. B56epsilon is alternatively translated adds a new level of regulation to PP2A holoenzymes PMID: 19129191
29. Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms. PMID: 19564615
30. Knockdown of PP2A inhibits forskolin-induced nuclear translocation of HDAC4 and attenuates the ability of this signaling molecule to repress collagen X expression in chondrocytes. PMID: 19704004
31. Study describes a novel Akt-dependent Pp2a activity that acts at least partly through Jun to affect initial barrier formation during late embryonic epidermal development. PMID: 19762425

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KEGG: mmu:51792

STRING: 10090.ENSMUSP00000007708

UniGene: Mm.294138