Recombinant Mouse Short transient receptor potential channel 6 (Trpc6), partial

1. TRPC6-/- mice show less collagen production and normal lung function in pulmonary fibrosis compared to wild-type controls. TRPC6 expression is up-regulated in TGF-beta1-induced lung fibroblast-myofibroblast transdifferentiation. PMID: 27932059
2. We conclude that TRPC6 channels of pancreatic stellate cells are major effector proteins in an autocrine stimulation pathway triggered by hypoxia. PMID: 28849300
3. findings link Trpc6-mediated Ca2+ signaling and nitrosative stress in the redox pathobiology of Duchenne muscular dystrophy PMID: 29187535
4. Administration of soluble klotho significantly reduced obstruction-induced renal fibrosis in wild-type mice, but not in Trpc6 knockout mice, indicating that klotho and TRPC6 inhibition act in the same pathway to protect against obstruction-induced renal fibrosis. PMID: 27979597
5. This study demonstrated that Transient Receptor Potential Canonical 6 (TRPC6) and Orai2 form stromal interaction molecule 2 (STIM2)-regulated neuronal-store-operated Ca(2+) influx (nSOC) channel complex in hippocampal synapse and the resulting Ca(2+) influx is critical for long-term maintenance of mushroom spines in hippocampal neurons. PMID: 27881772
6. ASIV may prevent HG-induced podocyte apoptosis via downregulation of TRPC6, which is possibly mediated via the calcineurin/NFAT signaling pathway. PMID: 27109610
7. the mTORC2/Akt/NFkappaB pathway-mediated activation of TRPC6 participates in adriamycin-induced podocyte apoptosis. PMID: 27960162
8. AngII-injured podocyte had a significant increase in apoptosis, while silencing TRPC6 could decrease the apoptosis induced by AngII. PMID: 25143325
9. transient receptor potential canonical 6 is an essential component of the slit diaphragm and is required for development of glomerulus PMID: 26363733
10. the transient receptor potential canonical-6 (TRPC6) calcium-permeable channel in the alveolar macrophages also functions to shunt the transmembrane potential generated by proton pumping. PMID: 26604306
11. Selectively activating endothelial TRPC6 rescues transendothelial migration PMID: 26392222
12. MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis. PMID: 25801675
13. These findings indicate that the mTORC2 signaling pathway regulates TRPC6 in podocytes but that the mTORC1 signaling pathway does not appear to exert an effect on TRPC6. PMID: 25393730
14. these findings provide strong evidence for a role of immunophilins, including FKBP25 and FKBP38, in NCCE mediated by TRPC6. PMID: 26239116
15. Results suggest that stretch-accelerated wound closure is due to the ATP release through mechanosensitive hemichannels from the foremost cells and the subsequent Ca(2+) waves mediated by P2Y and TRPC6 activation. PMID: 25097230
16. Results suggest that IL-17A may promote brain ischemia reperfusion injury through the increase of calpain-mediated TRPC6 proteolysis PMID: 24928352
17. Gq activation stimulated calcineurin, resulting in CN-dependent TRPC6 upregulation in murine kidneys. TRPC6 deletion in GqQ>L-expressing mice prevented FSGS development and inhibited tubular damage and podocyte loss induced by puromycin aminonucleoside PMID: 25844902
18. Renal ischemia-reperfusion injury induced podocyte effacement and the upregulation of TRPC6 mRNA and protein expression. In in vitro experiments, oxygen glucose deprivation (OGD) treatment enhanced the expression of TRPC6 and TRPC6-dependent Ca2+ influx. PMID: 25896763
19. a new pathway for TRPC6 activation by Phospholipase C epsilon PMID: 25521631
20. TRPC6 activity can occur independently of the physical interaction with Orai1 PMID: 24520961
21. Angiotensin receptor blockade and inhibition of local AngII production through angiotensin-converting enzyme inhibition prevented glucose-mediated increased TRPC6 expression. PMID: 24731445
22. was concluded that knocking down TRPC6 gene could effectively prevent podocytes from the permeability increase induced by PAN, which may be related to the regulation of podocyte cytoskeleton. PMID: 22684555
23. TRPC6 is sensitive to acidic pH but not to exposure to ROS or hypoxic-like conditions, which might be involved in the pathogenesis of the altered platelet responsiveness to DAG-generating agonists in disorders associated to acidic pH. PMID: 24074949
24. ATP evokes activation of TRPC6 channels in podocytes through P2Y receptors, podocin, and generation of reactive oxygen species. PMID: 24553432
25. In dystrophic hearts, excess contractility and arrhythmia are coupled to TRPC6 and are ameliorated by its targeted suppression or PKG activation. PMID: 24449818
26. Our results suggest an active participation of the intracellular TRPC6 fraction as a regulator of basal [Ca(2+)]c, controlling the passive Ca(2+) leak rate from agonist-sensitive intracellular Ca(2+) stores in resting platelets. PMID: 24462772
27. TRPC6 participates in the pathophysiological development of hypoxic pulmonary hypertension in the mouse model. PMID: 24144647
28. TRPC6 transgenic mice showed stronger CaMKII activation, reduced podocyte foot process effacement and reduced proteinuria during nephrotoxic serum nephritis, whereas TRPC6 null mice exhibited reduced CaMKII activation and higher levels of proteinuria. PMID: 24194522
29. In podocytes, TRPC6 channels interact with NOX2 and contributes to their activation by diacylglycerol. PMID: 23948707
30. The study identifies two spatially separated sites of TRPC6 channel crucial for the CaMKII-mediated regulation of TRPC6 channels. PMID: 23529130
31. ANP attenuates the inflammatory actions of histamine via endothelial GC-A/cGMP/cGKI signaling and inhibitory phosphorylation of TRPC6 channels. PMID: 23814119
32. our results establish a previously unknown function of NOD2 for the regulation of TRPC6 channels, suggesting TRPC6-dependent Ca(2+) signaling is one of the critical signal transduction pathways that links innate immunity mediator NOD2 to podocyte injury. PMID: 23856489
33. study shows a variety of mechanical stimuli cause activation of endogenously expressed TRPC6 channels of podocytes; also that podocin reduces sensitivity of TRPC6 channels to mechanical stimuli, so that a loss of podocin function would result in hyperactivation of TRPC6 channels in foot processes PMID: 23657570
34. Our results suggest that TRPC6 channels are in a key position to alter the information entry into the trisynaptic loop of the hippocampal formation from the entorhinal cortex PMID: 23193081
35. vitamin D down-regulates the enhanced TRPC6 expression in in vivo and in vitro podocyte injury. PMID: 23385000
36. Results indicate that diacylglycerol activated receptor operated calcium entry is mediated exclusively by TRPC6 in murine platelets, but this Ca(2+) influx has no major functional relevance for hemostasis and thrombosis. PMID: 22176814
37. TRPC6 inhibits NMDA receptor-triggered neurotoxicity and protects neurons from ischemic brain damage. PMID: 23043486
38. The results demonstrate an obligate function for TRPC6 and calcineurin in promoting myofibroblast differentiation, suggesting a comprehensive pathway for myofibroblast formation in conjunction with TGF-beta, p38 MAPK, and SRF. PMID: 23022034
39. Developmental changes in TRPC6 expression might be required for proper postnatal development of the hippocampus and the kidney cortex. PMID: 22701654
40. TRPC6 channel activation is essential for lung ischaemia-reperfusion induced oedema in mice PMID: 22337127
41. PI3K/PTEN pathway plays an important role in the translocation of TRPC6 to the plasma membrane and may thus have a significant impact on Ca(2+) signaling in cells that endogenously express TRPC6. PMID: 22493444
42. TRPC6 deletion in mice results in defects in hemostasis and protection against thrombogenesis, suggesting a vital role in platelet function. PMID: 22206677
43. Insulin increases generation of reactive oxygen species in part through activation of NADPH oxidases, and that this step contributes to modulation of podocyte TRPC6 channels. PMID: 22031853
44. [review] The sequence of events linking cytochrome P450 epoxygenase activation, bioactive epoxides and TRPC6 channels in acute hypoxic pulmonary vasoconstriction goes a long way to explaining the molecular events underlying the phenomenon. PMID: 20588188
45. The deleterious effects of AngII on podocytes and its pathogenic role in glomerular disease involve enhanced TRPC6 expression via a calcineurin/NFAT positive feedback signaling pathway. PMID: 21839714
46. a new signaling pathway of ROS-TRPC6 in controlling vessel contraction by vasoconstrictors. PMID: 21768109
47. Protein kinase A-mediated phosphorylation of TRPC6 at Thr69 is essential for the vasorelaxant effects of PDE3 inhibition against the vasoconstrictive actions of angiotensin II. PMID: 21799177
48. A new basal phosphorylation site (Ser(814)) on TRPC6, was identified. PMID: 21448286
49. TRPC6 promotes albuminuria, perhaps by promoting angiotensin II-dependent increases in Ca(2+). PMID: 21258036
50. Knocking-down TRPC6 could effectively decrease the puromycin aminonucleoside-induced apoptosis of podocytes. PMID: 19662354

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KEGG: mmu:22068

STRING: 10090.ENSMUSP00000057965

UniGene: Mm.325086