Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-2 (Atp1a2), partial

1. proof of concept study demonstrates that reduced expression of the alpha2 isoform in the spinal cord is protective following spinal cord injury PMID: 28886701
2. Atp1a2 does contribute to alcohol-related behaviors, but the effect is modest with a clear dependence on sex. PMID: 27814792
3. Atp1alpha2 is preferentially expressed with Atp1beta2 in T-tubules of cardiac myocytes, forming alpha2beta2 heterodimers. PMID: 27624940
4. study provides evidence that muscle beta-catenin is crucial for maintenance of resting membrane potential(RMP)of skeletal muscle cells; muscle cells lacking beta-catenin show decreased expression of alpha2 subunit of Na,K-ATPase, a probable mechanism by which beta-catenin regulates RMP and affects normal function of skeletal muscle PMID: 24674304
5. Heart expression of alpha2 does not play a role in the regulation of basal cardiovascular function or blood pressure; however, heart expression of alpha2 plays a role in the hypertrophic response to pressure overload. PMID: 23436327
6. Atp1a2 has a more prominent role (vs. Atp1a1) in modulating cardiac myocyte sarcoplasmic reticulum Ca(2+) release. PMID: 22739122
7. The ouabain-binding site of either the alpha1 or alpha2 Na,K-ATPase subunit does not play an essential role in the development of DOCA-salt hypertension in a mouse model PMID: 22258333
8. Central sodium chloride causes hypertension in mice. The blood pressure response is mediated by the ouabain-like substance in the brain, specifically by its binding to the alpha(2)-isoform of the Na,K-ATPase. PMID: 21856907
9. Atp1a2 expression in heart and vascular smooth muscle is not essential for regulation of basal systolic blood pressure. PMID: 21856916
10. Ion channel NKCC1 and alpha2 Na, K-ATPase played important roles in the inner ear potassium recycling. PMID: 17111813
11. Both protein and mRNA expression of alpha1 and alpha2 isoforms of Na,K-ATPase and NKCC1 in the lateral wall were dramatically reduced following a long-term deafening PMID: 21094218
12. The cardiotonic steroid-binding site of the alpha2 Na,K-ATPase plays a role in maintaining normal SBP during pregnancy PMID: 20940714
13. The Na,K-ATPase alpha(2) subunit is expressed during development when the t-tubules form. These results suggest that the alpha(2) isoform may serve, in part, a physiological role in the muscle t-tubules. PMID: 12397396
14. Na,K-ATPase alpha2 isoform could be important in the modulation of neuronal activity in the neonate PMID: 12458206
15. Ca2+ signaling is regulated by the expression of this protein as studied in knockout mice PMID: 12763872
16. Heterozygote Atp1a2 mutant adult mice showed increased fear/anxiety behavior and enhanced neuronal activity in the amygdala and piriform cortex after conditioned fear stimuli; homozygotes died just post-birth and showed neuronal apoptosis in these regions PMID: 12805306
17. the alpha2 Na,K-ATPase isozyme mediates ouabain-induced cardiac contractility in mice PMID: 14559919
18. individual alpha-isoforms of the Na(+)/K(+)-ATPase differ functionally and that the alpha(2)-isoform couples more strongly to activation-relaxation pathways in vascular smooth muscle PMID: 14627611
19. the alpha2-isoform of Na-K-ATPase mediates the ouabain-induced increase in vascular contractility and could play a role in the development and maintenance of ouabain-induced hypertension. PMID: 15458945
20. We propose a model for functional coupling between the Na+, K+-ATPase alpha2 subunit and KCC2, which excludes Cl- from the cytosol in respiratory center neurons. PMID: 15564586
21. Accordingly, in salt-dependent hypertension, EOLC probably increases vascular resistance and blood pressure by reducing alpha2 Na(+) pump activity and promoting Ca(2)(+) entry via NCX in myocytes. PMID: 16166162
22. Leu-27 and Ala-35 are essential for targeting/tethering Na+ pump alpha2 subunits to plasma membrane (PM) microdomains overlying "junctional" sarco-/endoplasmic reticulum PMID: 16524882
23. Learning and memory deficits observed in Na,K-ATPase alpha2 and alpha3 mice reveal Na,K-ATPase to be an important factor in the functioning of pathways associated with spatial learning. PMID: 17234593
24. Present 3D structural model of Atp1a2. PMID: 17552883
25. double heterozygote deletion of NKCC1 with alpha(2)-Na,K-ATPase demonstrates a striking preservation of hearing threshold both initially and with age. PMID: 17674100
26. Coupling between the two respiration-related rhythm generators did not function in the normal manner in Atp1a2(-/)(-) mice. PMID: 17690149
27. FGF23 transgenic mice display differentially expressed transcript levels of several genes (Npt2a, Pdzk1, Atp1a2) essential in renal Pi regulation. PMID: 17911089
28. differential distribution of alpha-subunits of the Na+/K+-ATPase in subicular interneurones and pyramidal cells PMID: 17947306
29. studies of the behavioral aspects of alpha1, alpha2, and alpha 3 deficient mice show that haploinsufficiency of both alpha2 and alpha 3 isoforms result in behavioral defects. PMID: 18044013
30. Our findings support the concept of a subsarcolemmal space where the alpha 2-isoform coupled with Na+-Ca2+ exchanger modulates Ca2+-store function and Ca2+ entry PMID: 18192219
31. ACTH-induced hypertension is dependent on the ouabain-binding site of the alpha2-Na+-K+-ATPase subunit. PMID: 18487447
32. Chronic downregulation of Na(+)-K(+)-ATPase alpha(2)-isoform expression by heterozygous knockout increases the pressor response to increased CSF [Na] and activates the brain renin-angiotensin system. PMID: 19244589

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KEGG: mmu:98660

STRING: 10090.ENSMUSP00000083077

UniGene: Mm.207432