Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-3 (Atp1a3), partial

1. A heterozygous knock-in mouse harboring the D801Y mutation in ATP1A3 was generated. This mice displayed hyperactivity, increased sensitivity to chemically induced epileptic seizures and cognitive deficits. The findings reveal the functional significance of ATP1A3 gene in the control of spatial learning and memory and suggest a link to GABA transmission. PMID: 27549929
2. Knockout of sodium pump alpha3 subunit gene (Atp1a3(-/-)) results in perinatal seizure and defective respiratory rhythm generation PMID: 28465228
3. Mice harboring a heterozygous hot spot disease mutation, D801Y suffer abrupt hypothermia-induced dystonia. D-to-Y mutation abolished pump-mediated Na+/K+ exchange. PMID: 28472154
4. Myshkin mice carrying a wild-type Atp1a3 transgene that confers a 16 % increase in brain-specific total Na(+),K(+)-ATPase activity show significant phenotypic improvements compared with non-transgenic Myshkin mice. PMID: 26463346
5. Heterozygous Myshkin mice have an amino acid change (I810N) in Na+,K+-ATPase alpha3 and deficits in learning and memory consistent with the cognitive impairment of the vast majority of Alternating Hemiplegia of Childhood patients PMID: 26501181
6. findings show Atp1a3-deficient heterozygotes exhibited shorter stride length at 4 weeks of age without stress and at later stages under chronic restraint stress; Atp1a3 was widely expressed in the brain and spinal cord of young mice; expression pattern was compatible with movement abnormalities under lack of one of alleles PMID: 24983657
7. These results shed light on the role of Atp1a3 in the inhibitory synapse, and potential involvement of inhibitory synaptic dysfunction for the pathophysiology of dystonia. PMID: 23652595
8. The results reveled that the NKAalpha3 subunit is found within gamma-motoneurons of spinal cord. PMID: 23761886
9. Increased Atp1a3 protein levels in the hippocampus provide evidence for its possible role in mechanisms that parallel memory training. PMID: 22797008
10. We found that a mutation that decreases neuronal Na(+) ,K(+) -ATPase activity interacts with stress to exacerbate depression. PMID: 21418141
11. Retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis, membrane association is severely impaired in the absence of ATP1A3 and ATP1B2. PMID: 21196491
12. Stress induced deficits in motor coordination and balance in female Atp1a3 mutant (Het) mice. These mice also exhibited decreased thermal sensitivity, as well as altered circling patterns and monoamine systems. PMID: 20850480
13. Data show that ATP1alpha(3) is widely expressed in neuronal populations but mainly in GABAergic neurons in areas and nuclei related to movement control, in agreement with rapid-onset of dystonia parkinsonism symptoms. PMID: 21165980
14. These data demonstrate that, through its interaction with the alpha3 sodium-potassium ATPase, agrin regulates activity-dependent processes in neurons, providing a molecular framework for agrin action in the CNS. PMID: 16630822
15. while ATP1A3-isoforms regulate sodium and potassium homeostasis in subicular interneurones, ATP1A1-isoforms assume this function in pyramidal cells PMID: 17947306
16. the basal frequency of myocyte contraction depends on endogenous agrin-alpha3 Na,K-ATPase interaction PMID: 19376779
17. the Na(+),K(+)-ATPase alpha3 isoform has a role in the control of epileptiform activity and seizure behavior PMID: 19666602

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KEGG: mmu:232975

STRING: 10090.ENSMUSP00000099922

UniGene: Mm.44101