Recombinant Mouse T-box transcription factor TBX21 (Tbx21)

1. Data show that interleukin-2 inducible T cell kinase (Itk)negatively regulates the development of nTh1 cells that express interferon-gamma (IFNgamma) in a T-bet transcription factor (Tbet) independent manner. PMID: 28406139
2. The enhanced Th1 and Th2 immune response in K + O immunized mice was also supported by the increased expression of Tbx21 and GATA-3 transcription factors in splenocytes. This corroborated with increased BLIMP-1 and Oct-2 protein expression. PMID: 29486619
3. T-bet expression by T cells is not required for the induction of colitis or the differentiation of pathogenic Th17 cells but modifies qualitative features of the IL-23-driven colitogenic response by negatively regulating IL-23R expression. PMID: 27193261
4. Phosphorylation of T-bet by RSK2 is required for IFNgamma expression for attenuation of colon cancer metastasis and growth. PMID: 29133416
5. The Tbet pathway therefore directly impairs T-regulatory-cell reconstitution and is consequently a feasible target in efforts to prevent autoimmune graft-versus-host disease PMID: 28473623
6. IL-12 promoted increasing T-bet and down regulating Eomes to promote the CD8+ T cell differentiation to memory T-cells in invasive pulmonary aspergillosis mouse model. PMID: 28924369
7. The data are consistent with a looping/synapsing model for transcriptional regulation by T-bet in which a single dimer of the transcription factor can recognize and coalesce distinct genetic elements, either a promoter plus a distant regulatory element, or promoters on two different genes. PMID: 27791029
8. Arid5a deficiency resulted in decreased levels of IFN-gamma under Th1 cell conditions, in which T-box expressed in T cells (T-bet) mRNA expression was inhibited. PMID: 27671645
9. the model of mutually antagonistic differentiation programs driven by mutually exclusively expressed T-bet or GATA-3 does not completely explain natural CD4 T cell priming outcomes PMID: 29088218
10. T-bet expression by Th cells is not required for the manifestation of T-cell-induced colitis in the presence of segmented filamentous bacteria and Helicobacter hepaticus. T-bet expression by Th cells controls their survival and localization, their repertoire of chemokine and chemokine receptor expression, the accumulation of monocytes and macrophages in the inflamed colon. PMID: 26883725
11. T-bet acts through enhancers to allow the recruitment of Mediator and P-TEFb in the form of the super elongation complex. PMID: 27292648
12. results suggest that T-bet(+) Treg cells have an essential immunosuppressive function and indicate that Treg cell functional heterogeneity is a critical feature of immunological tolerance PMID: 28607488
13. results establish a novel mechanism by which mTORC1 regulates Th1 differentiation, through control of T-bet phosphorylation. PMID: 28424242
14. Conditional deletion of T-bet from B cells impaired the formation of germinal centers and mitigated the development of kidney damage and rapid mortality in systemic lupus erythematosus mice. PMID: 28240602
15. this study shows that T-bet restrains IFN-gamma-induced collateral type I IFN circuitry in the Th1 response in vivo PMID: 28623086
16. Cell migration is impaired in T-bet deficient Th17 cells in the central nervous system. PMID: 27242075
17. Our data suggest that T-bet might contribute to the remission of CIA by facilitating the regulatory potential of IL-10-positive MZ B cells. PMID: 27343199
18. There is a genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis. PMID: 27125523
19. Our findings suggest that T-bet over-expression-induced suppression of Th17 differentiation is mediated through IFN-gamma-independent AHR suppression. PMID: 27936495
20. this study reveales a new mechanism through which procyanidin B2 gallates inhibit IFN-gamma and IL-17 production in T cells by down-regulation of T-bet and RORgammat expression PMID: 28088699
21. the key role of the transcription factor c-Myb in regulating the T-bet-mediated anti-viral program, is reported. PMID: 28423310
22. T-bet regulates natural regulatory T cells migration into afferent lymphatics and lymph nodes and consequently their suppressive stability in vivo PMID: 26880765
23. These data advance our understanding of the transcriptional regulation of megakaryopoiesis by supporting a new role for T-bet in the differentiation of MEPs into megakaryocytes. PMID: 26607595
24. T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice PMID: 26903480
25. the effect of T-bet deletion in apolipoproteinE (ApoE) knockout mice fed a high fat diet (HFD) or normal chow diet, was studied. PMID: 26886778
26. Dominance of regulatory T cells in carcinogen-induced fibrosarcomas is not T-bet or Il-2 dependent. PMID: 26433463
27. a critical role for IRF4 in regulating protective anti-viral CD8+ T cell responses by ensuring a balanced ratio of T-bet to Eomes PMID: 26714260
28. Cytokines analysis in peritoneal fluid showed that IFN-gamma was significantly increased in chlorhexidine gluconate (CG)-injected T-bet Tg mice and that IL-13 was significantly increased in CG-injected GATA-3 Tg mice PMID: 26156402
29. Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer PMID: 26214042
30. is associated with the increased expression of T-bet in T cells PMID: 26461455
31. Data show that although T and B cell infiltration into the central nervous system of infected T-bet transcription factor knockout (T-bet-/-) mice is comparable, their activities are not, resulting in delayed, low-level antibody production . PMID: 26408670
32. T-bet is required for Th1 differentiation and migration, as well as for optimal function of Th17 cells. PMID: 25404360
33. Studies indicate that a key feature of age-associated B cells (ABCs) is that they express and depend upon B cell-intrinsic expression of the T-bet transcription factor. PMID: 26297793
34. T-bet as a key transcriptional regulator of tumor-reactive CD8(+) T-cell effector differentiation under otherwise tolerizing conditions. PMID: 25516478
35. methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx. PMID: 24934598
36. T-bet-deficient recipients of complete MHC-mismatched lung allografts develop costimulation blockade-resistant rejection characterized by neutrophilia and obliterative airway inflammation that is predominantly mediated by CD8(+)IL-17(+) T cells. PMID: 25286244
37. Data show that transcription factor T-bet expression level was lower in OCH glycolipid treatment group than in bone marrow failure (BMF) group. PMID: 25254224
38. these data highlight T-bet-independent pathways to IFN-gamma production and reveal a novel role for this transcription factor in coordinating the T cell responses necessary to control this infection in peripheral tissues. PMID: 25556247
39. These findings reveal an unexpected link between T-bet overexpression in T lymphocytes and the development of pulmonary alveolar proteinosis caused by reorganization of mononuclear phagocytes in the lung PMID: 25349175
40. Inflammation in acute microbial infection induced T-bet and Eomes. It promoted effector differentiation of self-reactive T cells in tolerance-favoring conditions. In Listeriosis, these responses relied on elevated T-bet expression, independent of Eomes. PMID: 24823810
41. T-bet stimulates epigenetic remodeling of Tmevpg1-specific enhancers and Ifng-specific enhancers to achieve Th1-lineage-specific expression of Ifng. PMID: 25225667
42. T-bet undergoes several post-translational protein modifications, such as phosphorylation and ubiquitination, which affect lineage commitment during T-cell differentiation. (Review) PMID: 24901011
43. This study reveals a function of T-bet as a central transcriptional regulator linking agonist selection and IL-15 signaling with the emergence of CD8alphaalpha(+) intraepithelial lymphocytes. PMID: 25148024
44. cooperation between the transcription factors T-bet and Runx3 resulted in suppression of conventional CD4(+) T helper functions and induction of an intraepithelial lymphocyte (IEL) program that included expression of IEL markers such as CD8alphaalpha homodimers. PMID: 25148025
45. T-bet modulates the antibody response and immune protection during murine malaria. PMID: 25047384
46. The role of T-bet in promoting the course of the disease demonstrated that T-bet was a critical factor in collagen-induced arthritis development. PMID: 24425064
47. These findings identify T-bet as a potentially important susceptibility factor for nickel nanoparticle exposure PMID: 24499286
48. Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice. PMID: 24927559
49. Ezh2 was also required to prevent proteasome-mediated degradation of T-bet protein in Th1 cells. PMID: 24760151
50. The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-gamma-producing T helper 17 cells. PMID: 24530058

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KEGG: mmu:57765

STRING: 10090.ENSMUSP00000001484

UniGene: Mm.94519