Recombinant Mouse TIR domain-containing adapter molecule 1 (Ticam1), partial

1. Findings confirm that signalling through MyD88 is the primary driver for Lipopolysaccharide-dependent NF-kappaB translocation to the nucleus. The pattern of NF-kappaB dynamics in TRIF-deficient cells does not, however, directly reflect the kinetics of TNFalpha promoter activation, supporting the concept that TRIF-dependent signalling plays an important role in the transcription of this cytokine. PMID: 28469251
2. Mice with myeloid cell specific TIR-domain-containing adapter-inducing interferon-beta (TRIF) knockout showed a trend towards accelerated onset of STZ-induced diabetes, while TRIF deficiency resulted in reduced IDO expression in vivo and in vitro. MyD88 signaling in myeloid cells is a critical pathogenic factor in autoimmune diabetes, which is antagonized by TRIF-dependent responses. PMID: 29522531
3. Findings suggest that Toll/IL-1R domain-containing adapter-inducing IFN-beta may be involved in the epileptogenesis of temporal lobe epilepsy, which would make it a potential therapeutic target for the treatment of epilepsy. PMID: 28867282
4. The TLR3/TICAM-1 pathway inhibits polyposis through suppression of c-Myc expression and supports long survival in Apc (Min/+) mice. PMID: 29041928
5. Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs PMID: 28912382
6. TRIF contributes to murine host defense during the initial response to leptospiral infection PMID: 27259371
7. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF/NF-kappaB-regulated apoptosis and the p53/PCNA- and ATM/ATR-Chk1/2-controlled DNA-damage response pathways. PMID: 26887372
8. Results show that Monophosphoryl lipid A-induced neutrophil and monocyte recruitment, expansion of bone marrow progenitors and augmentation of neutrophil adhesion molecule expression are regulated by both the MyD88- and TRIF-dependent pathways. PMID: 27354411
9. Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3), TIR domain-containing adapter inducing IFN-beta (TRIF), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 and TRIF. PMID: 28049150
10. These results suggested the importance of TRIF in TLR2 mediated foam cell formation via inflammatory mediators, including MCP-1. PMID: 27572666
11. DENV replication and IFNalpha/beta, TNF-alpha, IL-12 and IL-18 in infected cultures at 24h were found. All of these parameters were significantly decreased after TRIF, MYD88 or NF-kB inhibition PMID: 27575706
12. The authors demonstrate that, in addition to MyD88, Yersinia pseudotuberculosis inhibits TRIF signaling through the type III secretion system effector YopJ. PMID: 26651944
13. Results show that toll/IL-1 domain-containing adaptor inducing IFN-beta (TRIF) is essential for Toll-like receptors TLR3- and TLR4-mediated innate immune responses in peritoneal mesothelial cells (PMCs). PMID: 26579632
14. Data show that annexin A2 (AnxA2) directly exerted negative regulation of inflammatory responses through Toll-like receptor 4 (TLR4)-initiated TRAM protein-TRIF protein pathway occurring on endosomes. PMID: 26527544
15. ProTalpha preconditioning-induced prevention of retinal ischemic damage is mediated by selective activation of the TIR-domain-containing adapter-inducing interferon-beta interferon regulatory factor 3 pathway downstream of toll-like receptor 4 in microglia PMID: 26364961
16. signaling through TRIF is important for the inflammatory response of AngII-induced abdominal aortic aneurysm formation PMID: 26100679
17. analysis of how MyD88 and TRIF affect TLR4 activation PMID: 26175492
18. In mice with nonfunctional TRIF (Trif(mut) mice), Ang II-induced hypertension and cardiac hypertrophy were abrogated, and proinflammatory gene expression in heart and kidneys was unchanged or decreased. These results indicate that Ang II induces activation of a proinflammatory innate immune response, causing hypertension and cardiac hypertrophy, which require functional adaptor protein TRIF-mediated pathways. PMID: 26195481
19. Ang II induces activation of a proinflammatory innate immune response, causing hypertension and cardiac hypertrophy. These effects require functional adaptor protein TRIF-mediated pathways. PMID: 26195481
20. Data indicate that Toll-like receptor 4 (TLR4) endocytosis and the TIR-domain-containing adapter-inducing IFN-beta (TRIF)-signaling pathway in macrophages during endotoxin tolerance in the absence of cluster of differentiation 14 (CD14). PMID: 26106158
21. A MAVS/TICAM-1-independent interferon-inducing pathway contributes to regulation of hepatitis B virus replication PMID: 25115498
22. signaling is involved in the antitumor activity of poly I:C PMID: 24192491
23. Trif was mainly present in the ganglion cell layer(GCL)after ischemia-reperfusion (IR) injury. Retinas of TrifKO mice had a significantly reduced neurotoxic pro-inflammatory response and significantly increased survival of the GCL neurons after IR. PMID: 24754835
24. Mice with single or double deficiencies in these MyD88 and TRIF had reduced responses, based on finding fewer GFPhi Retinal dendritic cell in injured retinas post-optic nerve crush injury. PMID: 25116321
25. Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling. PMID: 25305320
26. The results identify TRIF signaling as a truly homeostatic pathway to maintain intestinal epithelial barrier function revealing fundamental differences in the innate immune signaling between mucosal homeostasis and tissue repair. PMID: 25210121
27. Caspase-1 directly cleaved TRIF to diminish TRIF-mediated signaling, resulting in inhibition of autophagy and in reduced type I interferon production in Pseudomonas aeruginosa infected macrophages. PMID: 24528867
28. The role of TRIF signaling is early rejection of allogeneic bone marrow transplantation by macrophages or NK Cells. PMID: 23146386
29. TLR3-Trif signaling represents an injurious pathway during myocardial ischemia reperfusion injury. Extracellular RNA released during I/R may contribute to myocardial inflammation and infarction. PMID: 24390148
30. These observations suggest a critical role for the MyD88 pathway in initiating neuropathic pain, but a distinct role for the TRIF pathway and interferon in regulating neuropathic pain phenotypes in male mice. PMID: 24321498
31. Data indicate that Toll/IL-IR domain-containing adapter-inducing IFN-beta (TRIF) signaling is essential for TLR4/LPS-driven IgE class switching. PMID: 24532577
32. Data indicate that signalling through the TRIF and TRAM pathways downstream of TLR3 and TLR4 in bone-marrow cells promote the development of atherosclerosis. PMID: 23417039
33. MyD88 and TRIF must be expressed in the same cell for the in vivo T(H)1-skewing adjuvant activity, indicating these two signaling pathways cooperate on an intracellular level. PMID: 23716300
34. protective properties of Hsp70 are TLR4 adapter Trif dependent and MyD88 independent. PMID: 23817427
35. A novel, gender specific protective role was found for TRIF (and CX3CR1) signaling in a model of neonatal hypoxic-ischemic brain injury. PMID: 23843525
36. these data suggest that hyperlipidemia resulting in endogenous activation of the TRIF signaling pathway from TLR4 leads to pro-atherogenic events. PMID: 22637968
37. ATO prevents NO production by inhibiting the TIR-domain-containing adaptor protein inducing IFN-beta (TRIF)-dependent pathway. PMID: 23106696
38. TLR2-mediated TRIF signaling is dependent on the presence of another adaptor molecule, MyD88. PMID: 23166161
39. WWP2 negatively regulates TLR3-mediated innate immune and inflammatory responses by targeting TRIF for ubiquitination and degradation. PMID: 23479606
40. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. PMID: 23223360
41. TLR4- and TRIF-induced caspase-11 synthesis is critical for noncanonical Nlrp3 inflammasome activation in macrophages infected with enteric pathogens. PMID: 22898816
42. Secretion of interleukin (IL)-1beta upon bacterial RNA stimulation is independent of TRIF. PMID: 22634614
43. This study provided the evidence that TRIF-mediated signaling plays an unexpected role in axonal debris clearance by microglia, thereby facilitating a more permissive environment for axonal outgrowth. PMID: 22649252
44. the D299G polymorphism compromises recruitment of MyD88 and TRIF to TLR4 without affecting TLR4 expression, TLR4-MD2 interaction, or LPS binding, suggesting that it interferes with TLR4 dimerization PMID: 22474023
45. Data show that toll-like receptors (TLRs)-TRIF signalling activates eIF2B GEF through PP2A-mediated serine dephosphorylation of the eIF2B varepsilon-subunit. PMID: 22231169
46. TLR4-TRIF axis has an important role in stimulating protective innate immunity against H5N1 influenza A virus infection. PMID: 22031950
47. Findings strongly support the concept that LMP7/MECL-1 proteasomes subunits actively function to regulate LPS-induced NO production by affecting the TRIF/TRAM pathway. PMID: 21455681
48. disruption of MyD88 or TRIF signaling does not confer protection in brain ischemia PMID: 21376021
49. results demonstrate that TLR4 signaling, via the downstream MyD88 and TRIF molecules, exerts a differential regulation on the CD4(+) T cell response to Porphyromonas gingivalis hemagglutinin B antigen PMID: 21498664
50. Toll/IL-1R domain-containing adapter (TICAM1-) induces interferon-beta in wound healing by regulating chemokine production and recruitment of myeloid cells to the wound for tissue repair. PMID: 21317384

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KEGG: mmu:106759

STRING: 10090.ENSMUSP00000055104

UniGene: Mm.203952