Recombinant Mouse Thioredoxin (Txn)

1. Study in transgenic mice finds that T-cell activation is linked to a drastic downregulation of Txnip and an increase in Txn1/Txnrd1 expression, which is absolutely required for synthesis of 2'-deoxyribonucleotides during T-cell metabolic reprogramming. These results uncover a pivotal function of the Trx1 system in metabolic reprogramming of thymic and peripheral T cells. PMID: 29749372
2. Up-regulation thioredoxin resulted in decreased intracellular ROS generation and the underlying mechanism is related to inhibition of the Txnip/mTOR pathway mediated autophagy. PMID: 30384364
3. mTOR is a direct interacting partner of Trx1 in the heart. Trx1 protects cardiomyocytes against oxidative stress by reducing mTOR at Cys-1483, thereby preserving the activity of mTOR and inhibiting cell death. PMID: 28939765
4. By establishing that IL-4 is posttranslationally regulated by TRX-promoted reduction of a disulfide bond, our findings highlight a novel regulatory mechanism of the type 2 immune response that is specific to IL-4 over IL-13. PMID: 30104382
5. Nox2 activation favors thioredoxin-1 (TRX-1)/p40phox interaction, which leads to exclusion of TRX-1 from the nucleus. PMID: 27698473
6. These results suggest that overexpression of Trx-1 may occlude the CPP induced by METH through regulating the activity of CREB and the expression of DeltaFosB. PMID: 28782589
7. A novel mouse model for the identification of thioredoxin-1 protein interactions has been created. PMID: 27639450
8. Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms, in particular, by the serum QSOX1. PMID: 27581528
9. Nuclear overexpression of Trx1 restored Nrf2 activity and attenuated alcohol-induced acute lung injury. PMID: 27436123
10. Trx1 enhances blood perfusion and increases angiogenic protein expression in a rodent hind limb ischemia model. PMID: 28807201
11. GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea; the thioredoxin/thioredoxin reductase system can probably operate as a functional backup for GSR. PMID: 28686716
12. These results strongly suggest that Trx1 ameliorates the myocardial effects of I/R by improving the free radical-mediated damage in cardiac and mitochondrial function, opening the possibility of new therapeutic strategies in coronary artery disease. PMID: 27000416
13. Thioredoxin-mediated deglutathionylation of eNOS in the coronary artery in vivo protected against reperfusion injury, even in the presence of normal levels of glutathione. PMID: 27587398
14. Acute stimuli of epinephrine induced Trx-1 expression through activating CREB. PMID: 27511023
15. results suggest that PostC prevents Trx-1 degradation, decreasing oxidative stress and allowing the activation of Akt and GSK3beta to exert its cardioprotective effect PMID: 26932791
16. GL-V9 attenuated DSS-induced colitis against oxidative stress by up-regulating Trx-1 via activation of AMPK/FOXO3a pathway. PMID: 26327408
17. The ventral signal observed from E12.5 onward colocalized with motor neuron markers Isl1/2 and FoxP1. and the strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord PMID: 25975898
18. the timely upregulation of Trx1/TrxR1 and the active control of intracellular redox status is critical for the survival of thymocytes during and short after positive selection. PMID: 25753394
19. Trx1 may also modulate lysine methylation, a non-redox post-translational modification, via the regulation of SMYD1 expression PMID: 26410624
20. Translocation of Trx1 from cytoplasm to cell nuclei plays an important role in disturbed flow-stimulated proatherogenesis with greater cytoplasmic protein oxidation and an enhanced nuclear transcription factor activity. PMID: 25265386
21. Our results indicate a close relationship between Trx1 and the 20S nuclear proteasome PMID: 23850970
22. Data indicate that Trx-1 mediated endoplasmic reticulum and mitochondria pathways are involved in brain damage in myasthenia gravis PMID: 24878227
23. Suggest that urinary TRX1 is an oxidative stress-specific biomarker useful for distinguishing AKI from chronic kidney disease and healthy kidneys. PMID: 25350977
24. Thioredoxin-1 expression suppresses endoplasmic reticulum stress in a mouse model of Parkinson disease. PMID: 24140863
25. Therefore, we conclude that TIGAR knockdown-induced radiosensitization of glioma cells may be dependent on the inhibition of TRX1 nuclear translocation. PMID: 24509157
26. Thioredoxin-1 enhanced pulmonary mRNA expression of MAP kinase phosphatase 1 (MKP-1), and the suppressive effects of thioredoxin-1 on prolonged GM-CSF release and late neutrophilic inflammation disappeared by inhibiting MKP-1. PMID: 24244404
27. Thioredoxin-1 functions as a molecular switch to turn off the oxidative stress-induced activation of MST1. PMID: 23085515
28. TR1-deficient cells are more sensitive to TNF-alpha induced apoptosis than control cells. PMID: 24039713
29. Inhibition of Trx activity in the lung attenuates LPS-induced SNO-p65 denitrosylation, NF-kappaB activation, and airway inflammation, supporting a pathophysiological role for this mechanism in lung injury. PMID: 24338024
30. Thioredoxin-1 attenuates early graft loss after intraportal islet transplantation in mice. PMID: 23950917
31. Data indicate that thioredoxin was among the 32 proteins that displayed greater than a twofold increase in spectral counts in the bone marrow (BM) supernatant of AMD3100-treated transplant mice. PMID: 23994289
32. These results indicate that Trx functions as a physiological inhibitor of MPK38, which plays an important role in inducing ASK1-, TGF-beta-, and p53-mediated activity. PMID: 23747528
33. This study identifies Trx-1 as a novel interaction partner of the ADAM17 cytoplasmic domain. PMID: 23105116
34. Study identifies a role for Trx1 and its association with its regulatory proteins TXNIP, AKAP12, and subsequent activation of Akt/GSK-3beta/beta-catenin/HIF-1alpha-mediated VEGF and eNOS expression in inducing angiogenesis and reduced ventricular remodeling. PMID: 21074540
35. S. zooepidemicus uses SzP to recruit TRX and regulated the alternative complement pathways to evade the host immune phagocytosis PMID: 22384152
36. Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase. PMID: 22457359
37. male Tg(TRX1)(+/0) mice significantly extended the earlier part of life span compared with wild-type littermates, but no significant life extension was observed in females PMID: 21873593
38. Trx associates with the active site of 3-mercaptopyruvate sulfurtransferase to release hydrogen sulfide in brain mitochondria in vitro. PMID: 21732914
39. Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7. PMID: 21183740
40. DJ-1 has anti-oxidant and cytoprotective properties by regulating the thioredoxin 1 ASK1 complex and controlling the availability of ASK1 to effect apoptosis PMID: 20385180
41. TR1 and Trx1 interaction play key role in redox homoeostasis. PMID: 20536427
42. The roles of thioredoxin in protection against oxidative stress-induced apoptosis PMID: 11751890
43. Th1/Th2 balance is polarizated to Th1 in thioredoxin (TRX) transgenic mice during aging PMID: 11841834
44. In addition to an antioxidant effect, Trx has the potential to protect acute liver injury via an antiapoptotic effect, which mainly inhibits mitochondria-mediated apoptosis signaling. PMID: 12717382
45. increased levels of Trx-1 in human tumors could lead to functional inhibition of PTEN tumor suppressor activity providing an additional mechanism for tumorigenesis with loss of PTEN activity PMID: 15313215
46. critical role for the LIMK family in the regulation of ADF/cofilin and synaptic function in the brain. PMID: 15458846
47. The present study suggests that TRX-1 has potent antioxidant and anti-inflammatory actions in experimental acute pancreatitis and might be a new therapeutic strategy to improve the prognosis of severe acute pancreatitis. PMID: 16322089
48. increased ROS production in aged liver may alter the ratio of ASK1 and Trx-ASK1, thereby increasing the age-associated basal level of p38 MAPK pathway activity PMID: 16449798
49. results suggest that thioredoxin-1 may be a key signaling molecule regulating the early events in the IgE signaling in mast cells and allergic inflammation PMID: 16474438
50. The results suggest that, in cardiac myocytes, Trx1 upregulates mitochondrial proteins and enhances mitochondrial functions, possibly through PGC-1alpha and NRFs. PMID: 16987018

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KEGG: mmu:22166

STRING: 10090.ENSMUSP00000030051

UniGene: Mm.260618