Recombinant Mouse Tight junction protein ZO-1 (Tjp1), partial

1. Podocyte-specific deletion of the ZO-2 gene did not cause overt defects; however, double knockout of ZO-1 and ZO-2 genes accelerated the defects observed in ZO-1 knockout mice. These results suggest that ZO-2 plays supportive roles in the ZO-1-dependent regulation of podocyte filtration barrier. PMID: 29845705
2. the endothelial barrier was preserved in respiratory epithelium isolated from MCU-/- mice after exposure to IL-13. In the ovalbumin-model of allergic airway disease, MCU deficiency resulted in decreased apoptosis within the large airway epithelial cells. Concordantly, expression of the tight junction protein ZO-1 was preserved, indicative of maintenance of epithelial barrier function PMID: 29225050
3. Busulfan treatment down-regulated the epididymal expression of vimentin and zonula occludens-1 (ZO-1). PMID: 29101242
4. At 3days after the first tamoxifen injection, Akt1(-/-)/iAkt2 KO hearts showed decreased expression of connexin43 (Cx43) and connexin-interacting protein zonula occludens-1 (ZO-1). Furthermore, Akt1/2 silencing significantly decreased both Cx43 and ZO-1 expression PMID: 29378301
5. Overexpression of SHANK3 enhanced ZO-1 expression, and knockdown of SHANK3 resulted in decreased expression of ZO-1. Regulation of ZO-1 expression by SHANK3 seems to be mediated through a PKCepsilon-dependent pathway. The expression level of SHANK3 affects ZO-1 expression and the barrier function in intestinal epithelial cells in mice. PMID: 28906292
6. Endothelial cellsTLR4 strongly regulates retinal vessel permeability by reducing expression of occludin and zonula occludens 1. PMID: 29136627
7. Cx43 tethers the F-actin cytoskeleton through a ZO-1 linker and supports cell spreading and exploration during locomotion in cerebral endothelial cells. PMID: 26289751
8. Expression of Podocalyxin, which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 and ZO-2 and this correlates with an aberrant submembranous localization of Ezrin. PMID: 24905925
9. Zonula occludens-1, occludin and E-cadherin expression and organization in salivary glands PMID: 25248927
10. Tjp1 expression was decreased in glomerular diseases in human and animal models, our results indicate that the suppression of Tjp1 could directly aggravate glomerular disorders, highlights Tjp1 as a potential therapeutic target. PMID: 25184792
11. Arecoline increases the production of TNF-alpha and induces protein redistribution of ZO-1. PMID: 25200553
12. Vcl plays a crucial role in stabilizing gap junctions and myocyte integrity through direct interactions with ZO-1 and stabilization of CX43. PMID: 24413171
13. Activation of RhoA/ROCK1 by high glucose in diabetic nephropathy disrupts the expression and translocation of occludin/ZO-1, which can be corrected by simvastatin. PMID: 24244596
14. Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C epsilon-mediated zona occludens-1 phosphorylation at threonine 770/772. PMID: 24338688
15. The JAM-A and ZO-1 genes were highly expressed in all the tested tissues. PMID: 23568966
16. The results establish that ZO-1 acts as a true scaffolding protein and that the coordinated activity of multiple domains is required for normal TJ structure and function. PMID: 23418357
17. Findings reveal novel roles for ZO-1 in mESC self-renewal, pluripotency, and differentiation by influencing several signaling networks that regulate these processes. PMID: 22782886
18. results suggest that ARHGEF11 mediates RhoA-myosin light chain signaling pathways at cell-cell junctions, functioning in cooperation with ZO-1. PMID: 22665792
19. CPEB-mediated zonal occludens-1 mRNA localization is essential for tight-junction assembly and mammary epithelial cell polarity PMID: 22334078
20. Data indicate that Zo-1 is a response protein to inner medullary tonicity and that extracellular stressors can promote Zo-1 protein expression, tyrosine phosphorylation and cytoskeleton association. PMID: 21734410
21. Here we report the (15)N, (13)C, and (1)H chemical shift assignments of the first PDZ domain of mouse ZO-1. PMID: 21431884
22. ZO-1 redistribution is the earliest cellular event yet identified as a herald of physiological cell shedding, and redistribution of tight junction function along the lateral plasma membrane sustains epithelial barrier during cell shedding. PMID: 21346149
23. ZO-1 and ZONAB are critical for differentiation and homeostasis of the RPE monolayer and may be involved in RPE disorders such as proliferative vitroretinopathy and atrophic age-related macular degeneration PMID: 21209887
24. ZO-1, which is the central structural protein of the tight junction, is the binding partner of the cytoplasmic domain of mouse VSIG1 PMID: 20957455
25. PLEKHA7 is a cytoplasmic component of the epithelial adherens junction belt, distinct from ZO-1 and E-cadherin PMID: 20808826
26. suggest that MLCK-dependent ZO-1 exchange is essential to this mechanism of barrier regulation. PMID: 20404178
27. Surface plasmon resonance study of interaction of occludin with ZO-1 PMID: 11700038
28. Data show that a high level of ZO-1 is expressed in the mouse lens, and lens connexins were shown to co-immunoprecipitate with ZO-1. PMID: 12064591
29. colocalizes with nectin and afadin at the puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 hippocampal area PMID: 12717711
30. Demonstration of a ZO-1/Cx35 association suggests a regulatory and/or scaffolding role of ZO-1 at gap junctions that form electrical synapses between neurons in mammalian brain. PMID: 15090040
31. ZO-1 and ZO-2 function redundantly to some extent in junction formation/epithelial polarization but they are not functionally identical PMID: 15292177
32. common molecular mechanism of forming a helical bundle between the hinge region/GuK domain of ZO-1 and alpha-catenin and occludin is identified as a general molecular principle organizing the association of ZO-1 at adherens and tight junctions. PMID: 15548514
33. Tat decreased mRNA levels of ZO-1 and marked disruption of ZO-1 continuity and induced oxidative stress, affecting the integrity of the blood-brain barrier through the ERK 1/2 pathway. PMID: 15829913
34. ZO-1-mediated delivery of Cx43 from a lipid raft domain to gap junctional plaques. PMID: 15855237
35. focal VEGF and angiopoietin-2 hyperstimulation in the mouse brain increases MMP-9 activity and decreases ZO-1 protein PMID: 15947259
36. The results of this study extend the CNS cell types that express the ZO-1, demonstrate an additional connexin (Cx30) that directly interacts with ZO-1, and show the association of a MsY3 with ZO-1 localized to oligodendrocyte and astrocyte gap junctions. PMID: 16045494
37. Analysis showed increased ZO-1 membrane assembly in VEGF-treated RPE cells. Thus, VEGF has a dual capability with respect to the regulation of the expression of some TJ proteins at the transcriptional and post-translational levels depending on cell type. PMID: 16163490
38. Alterations in the content and localization of ZO-1 may be relevant to the pathogenesis of proteinuria in diabetes. PMID: 16567508
39. These findings indicate that ZO-1 and ZO-2 can independently determine whether and where claudins are polymerized. PMID: 16923393
40. ZO-1 plays crucial roles not only in TJ formation, but also in the conversion from "fibroblastic" AJs to belt-like "polarized epithelial" AJs through Rac1 activation. PMID: 17353356
41. loss of ZO-1 and increased permeability preceded the development of significant intestinal inflammation suggesting that in colitis alterations in the tight junction complex occur before the intestinal inflammation PMID: 17418867
42. Shroom2 and ZO-1 form a tight-junction-associated scaffolding complex, possibly linked to myosin VIIa, that bridges the junctional membrane to the underlying cytoskeleton, thereby contributing to the stabilization of these junctions. PMID: 17666436
43. These results suggest zonula occludens-1 interaction with connexin36 but not with Cx57 in the outer plexiform layer, and an absence of connexin57/connexin36 heterotypic gap junctional coupling in mouse retina. PMID: 17681699
44. Activation of HIF-1alpha in the brain of dystrophic mice coupled with VEGF and VEGFR-2 up-regulation and ZO-1 and claudin-1 rearrangement might contribute to both blood-brain barrier opening and increased angiogenesis. PMID: 17784876
45. These results suggest novel roles for ZO proteins as Src/Csk scaffolds potentially involved in the regulation of Src transformation. PMID: 18086565
46. Amyotrophic lateral sclerosis-linked superoxide dismutase 1 (SOD1) mutants with different biochemical characteristics disrupted the blood-spinal cord barrier in mice by reducing the levels of the tight junction protein ZO-1. PMID: 18344992
47. ZO-1 may be functionally important for cell remodeling and tissue organization in both the embryonic and extraembryonic regions, thus playing an essential role in embryonic development. PMID: 18353970
48. These results provide the first evidence that ZO-1 is involved in blastocyst formation from the morula by regulating accumulation of fluid and differentiation of nonpolar blastomeres to polar trophoblast cells. PMID: 18423437
49. analysis of ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula PMID: 18596233
50. ZO-1 knockdown, or combined ZO-1 and ZO-2 knockdown, generated a more severe inhibition of blastocoel formation indicating distinct roles for ZO proteins in blastocyst morphogenesis. PMID: 18817772

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KEGG: mmu:21872

STRING: 10090.ENSMUSP00000099652

UniGene: Mm.4342