Recombinant Mouse Tubulin beta-3 chain (Tubb3)

1. Here, we report that dissociation of UNC5C and polymerized TUBB3, the highly dynamic beta-tubulin isoform in neurons, is essential for netrin-1/UNC5C-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 mutations. PMID: 28483977
2. Tubb3 could be regulated by both Akt and Erk pathways. PMID: 26373733
3. It findings reveal that expression of relatively low levels of TUBB3 in mitotic cells can be detrimental for their cytokinesis and underscore the importance of CIT-K in counteracting this event. PMID: 26586574
4. Results suggest that down syndrome cell adhesion molecule collaborates with deleted in colorectal cancer to regulate microtubule dynamics via direct binding to dynamic TUBB3 in Netrin-1-induced axon branching. PMID: 25754961
5. Study shows the critical and specific role of Tubb3 on the stereotyped morphological changes and polarization processes that are required for initiating radial migration to the cortical plate. PMID: 24179174
6. this study reports that TUBB3, the most dynamic beta-tubulin isoform in neurons, directly interacts with the netrin receptor DCC, and that netrin-1 induces this interaction in primary neurons. PMID: 23641072
7. Access to a running wheel for 48h induced plastic changes in the expression of astrocyte beta-tubulin (III). Expression was increased in the cerebellum while much smaller increases were observed in the other motor regions. PMID: 23201358
8. interaction between alpha-syn and beta-III tubulin plays an important role in neuronal alpha-syn accumulation in an multiple system atrophy mouse model. PMID: 22227187
9. Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells. PMID: 21734264
10. these findings indicate that TGF-beta stimulated aberrant expression of class III beta-tubulin via activation of the ERK signaling pathway. PMID: 22037456
11. Endotatin can inhibit the expression of Tubulin-beta in retinal neovascularization. PMID: 20067108
12. High betaIII-tubulin is associated with tumorigenesis in non-small cell lung cancer. PMID: 20501838
13. Findings demonstrate that normal TUBB3 is required for axon guidance and maintenance in mammals. PMID: 20074521
14. TNF produced by activated glial cells in inflammatory or degenerative neurological diseases acts on neurites by acting on the kinesin-tubulin complex and inhibits axonal mitochondria and synaptophysin transport via JNK. PMID: 17068110
15. Transgenic mouse embryos overexpressing Wnt7a specifically in nestin-positive neural stem/progenitor cells displayed a delay in neuronal differentiation, assayed by beta-tubulin III expression. PMID: 17174942
16. A transgenic mouse class-III beta tubulin reporter using yellow fluorescent protein. PMID: 17868115
17. The expression of class III beta-tubulin was not related to retinal cell morphology or cell function, but rather to the cell lineage, suggesting that the expression of beta-tubulin III may be due to the retinal cell specific developmental program. PMID: 17900541

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KEGG: mmu:22152

STRING: 10090.ENSMUSP00000071134

UniGene: Mm.40068