Recombinant Mouse Tyrosine-protein kinase ZAP-70 (Zap70)

1. hypomorphic alleles of Zap70 or chemical inhibition of Zap70 catalysis leads to an increase of IFN-gamma-producing invariant natural killer T cells. PMID: 29980684
2. RanBP2 expression was regulated by Zap70. PMID: 28745977
3. disruption of normal Zap70 autoinhibition engaged negative feedback mechanisms by which negative selection and inhibitory receptors restrain TCR signaling to enforce both central and peripheral tolerance. PMID: 28159798
4. in this study, authors discovered a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T-cell antigen receptors, which turned them into a 'catalytic unit' that amplified antigenic stimuli PMID: 27869819
5. was significantly increased in 22-month AEW mice compared with 5-month AEW mice. ELISA data showed that secretions of IL-2 and NGF in 22-month AEW mice were higher than 5-month AEW mice. Our results indicate that increased ZAP70 is involved in dry skin in elderly pruritus. Increased secretion of IL-2 and NGF may induce dry skin itch. PMID: 27195291
6. this study shows that ZAP-70 mutation has a strong impact on T cell-driven arthritis in SKG model regardless of the genetic background PMID: 27040161
7. These findings establish Otud7b as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 function. PMID: 26903241
8. Data suggest that ring finger protein 41 Nrdp1 terminates T cell antigen receptors (TCRs) signaling by inactivating Zap70 kinase. PMID: 26390156
9. Zap70 as a structural protein regulates integrin-mediated control of actin and with its catalytic activity regulates T cell receptor-mediated control of actin and membrane remodelling during formation of the immunological synapse. PMID: 24596147
10. Blockade of CXCR7 suppressed MIF-mediated ERK- and zeta-chain-associated protein kinase (ZAP)-70 activation PMID: 26139098
11. mediates the CD4 lineage differentiation in response to Class II selecting ligands PMID: 25601273
12. In mice with spondylarthritis, microbiota content varied according to whether T cell receptor signal strength was normal or was impaired due to the ZAP-70(W163C) mutation. PMID: 25048686
13. expression of Zap70 protein was essential for both long-term survival of naive T cells and for their proliferation in response to lymphopenia. PMID: 25092893
14. ZAP-70 enhances the migration of malignant B-cells into the supportive microenvironment found in the bone marrow mainly by enhancing signaling and migration after CXCR4 stimulation. PMID: 24312539
15. Titration of Zap70 activity resulted in graded reductions in positive and negative selection but did not decrease the cumulative TCR signals integrated by positively selected OT-I cells PMID: 24908390
16. MIF promotes the migration of B cells through a ZAP-70-dependent pathway mediated by cooperative engagement of CXCR4 and CD74. PMID: 24760155
17. Report role of ZAP-70 kinase mutation/deletion on thymocyte-positive selection via CD69 signaling. PMID: 24266404
18. The forced intrathymic administration of histocompatible hematopoietic stem cells can sustain long-term thymopoiesis in ZAP-70-immunodeficient mice. PMID: 23305740
19. ZAP70 recruitment to the TCR and ZAP70 activation, revealed by its phosphorylation at tyrosine residues 292 and 319, were inhibited in T cells with a mutation in the proline-rich sequence of CD3 epsilon. PMID: 23267019
20. that CD3zeta mediates the ZAP-70/Syk kinase activation triggered by ephrinA-activated pathway to regulate early neuronal morphogenesis PMID: 21895656
21. Data observed a significant upregulation and phosphorylation of ZAP-70, protein kinase C theta;, nuclear factor of activated T cells, and glycogen synthase kinase 3beta in Tregs prepared from injury-site-draining lymph nodes. PMID: 20720513
22. Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways. PMID: 21393235
23. Results suggest that RhoH regulates TCR signaling via recruitment of ZAP-70 and Lck to CD3zeta in the immunological synapse. PMID: 21103055
24. These data provide evidence that a burst of ZAP-70 activity initiates the signaling pathways for negative selection. PMID: 20945976
25. conventional naive, effector and memory T cells were dependent on the kinase activity of Zap70 for their activation, which demonstrated a nonredundant role for Zap70 in signals induced by the T cell antigen receptor PMID: 21037577
26. temporal gradient in the amount of Zap70 protein enabled the selection of CD4(+) and CD8(+) repertoires in separate temporal windows and at different TCR signaling thresholds PMID: 20332428
27. These ZAP-70-deficient mice that received an intrathymic transplant had a significantly increased prothymocyte niche compared with their untreated counterparts. PMID: 20040762
28. ZAP-70 plays a role in the transition of pro-B to pre-B cells in the bone marrow. PMID: 12705855
29. spontaneous point mutation of the gene encoding an SH2 domain of ZAP-70, a key signal transduction molecule in T cells, causes chronic autoimmune arthritis in mice that resembles human RA in many aspects PMID: 14647385
30. ZAP-70 plays a distinct role in T cell activation and activation-induced cell death that involves the Fas/Fas ligand, caspase-8 and caspase-3 pathways. PMID: 14734724
31. ZAP-70 is essential for T-cell receptor signaling which induces the proliferation and the final maturation of dendritic epidermal T cells in the epidermis. PMID: 15740591
32. novel role for ZAP-70, which replaces SYK for continued t cell receptor signaling PMID: 17606633
33. A novel biochemical signature in memory CD4 T cells enables efficacious responses through increased Zap70 expression and reduced accumulation of downstream signaling events. PMID: 17785805
34. The pleiotropic functions of ZAP-70 and their differential response to graded variation provide a paradigm for understanding the complex outcomes of human genetic variation. PMID: 18093540
35. The thymic electro-gene transfer of the pCMV-ZAP-70-IRES-EGFP vector in these mice resulted in rapid T cell differentiation in the thymus with mature lymphocytes detected by three weeks in secondary lymphoid organs. PMID: 18446234
36. Zap70 can rescue the defective positive selection of immature B cells into the recirculating pool in Syk-deficient mice, demonstrating functional redundancy between these two kinases. PMID: 18465772
37. ZAP-70 mutations appear to skew the T Cell receptor repertoire in ways that differentially influence propensity to autoimmunity versus autoimmune disease susceptibility. PMID: 19841086

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KEGG: mmu:22637

STRING: 10090.ENSMUSP00000027291

UniGene: Mm.8038