Recombinant Mouse VEGF co-regulated chemokine 1(Cxcl17)

Code CSB-YP729385MO
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Source Yeast
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Code CSB-EP729385MO
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Source E.coli
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Code CSB-EP729385MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP729385MO
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Source Baculovirus
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Code CSB-MP729385MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Cxcl17
Uniprot No. Q5UW37
Alternative Names Cxcl17; Vcc1C-X-C motif chemokine 17; 6-Cys CXCL17; 13.6 kDa protein; VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17]
Species Mus musculus (Mouse)
Expression Region 23-119
Target Protein Sequence SPNPGVAR SHGDQHLAPR RWLLEGGQEC ECKDWFLQAP KRKATAVLGP PRKQCPCDHV KGREKKNRHQ KHHRKSQRPS RACQQFLKRC HLASFALPL
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions.
Gene References into Functions
  1. CXCL17 attenuates Imiquimod -induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells , which may be important for regulating excessive inflammation in psoriasis skin. PMID: 28389593
  2. CXCL17 is a novel macrophage chemoattractant that operates in mucosal tissues as a major regulator of inflammatory responses. PMID: 24973458
  3. These results suggest that aberrant expression of CXCL17 in tumor cells recruits immature myeloid-derived cells and promotes tumor progression through angiogenesis. PMID: 22952881
  4. VCC-1 plays a role in angiogenesis and possibly in the development of tumors in some tissue types[VCC-1] PMID: 16989774
Subcellular Location Secreted.
Protein Families Intercrine alpha (chemokine CxC) family
Tissue Specificity Detected in lung, trachea, lung, tongue thyroid, submaxillary gland, epididymis, and uterus tissues and at a lower level in ovary, prostate and in intestinal tissues.
Database Links

KEGG: mmu:232983

UniGene: Mm.10545

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