Recombinant Mouse Zinc finger protein GLI2 (Gli2), partial

1. Gli2 upregulation changed the cytokine expression profile in mouse pancreatic acinar cells, mainly decreasing the pro-inflammatory cytokines interleukin (IL)-6, interferon-gamma, and FasL. PMID: 30001532
2. Here by inducing expression of constitutively active Smoothened (SmoM2) or Gli2 (DeltaNGli2) in the adipocyte lineage of postnatal mice, the authors show that targeted activation of Hedgehog signaling suppresses high-fat-diet-induced obesity and improves whole-body glucose tolerance and insulin sensitivity. PMID: 29205155
3. mice with single-allele Gli2 mutations exhibit increased penetrance and severity of Holoprosencephaly in response to low-dose teratogen exposure. PMID: 27585885
4. Gli2, the major Hedgehog pathway transcriptional effector, acts within mouse mammary stromal cells to direct a hormone-responsive niche signaling program by activating expression of factors that regulate epithelial stem cells as well as receptors for the mammatrophic hormones estrogen and growth hormone. PMID: 28280246
5. Gli2 and Gli3 are dephosphorylated and activated in cilia and that impaired Gli2 and Gli3 processing in Ta3 mutant is at least in part due to a decrease in Gli2 and Gli3 phosphorylation. PMID: 28673820
6. studies identify a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 signaling PMID: 28461568
7. Gli2+/-;Gli3Delta699/+ mice can serve as a genetic mouse model for common DSD. PMID: 27814383
8. Despite increased production of full-length GLI2 and GLI3 isoforms, previously identified GLI targets important for mandibular and glossal development (Foxf1, Foxf2, Foxd1 and Foxd2) were transcriptionally downregulated in Kif3a(f/f);Wnt1-Cre embryos. PMID: 28286175
9. Our findings suggest that ciliopathic facial phenotypes are generated via loss of both GLI3R and GLI2R and that this pathology occurs via a de-repression mechanism. Furthermore, these studies suggest a novel role for GLI2R in craniofacial development. PMID: 27802276
10. the GLI2 protein level could serve as a feasible marker of ligand-dependent hedgehog activation in pancreatic neoplasms. PMID: 27543868
11. Study suggested that loss of Gli2 mRNA mediated the anterior-restricted defect in conditional Dicer knockdown mice and showed that miR-106b positively regulated Gli2 mRNA expression PMID: 25910616
12. Sufu deletion early in embryogenesis resulted in unstable Gli2 and Gli3 activity, leading to the ectopic activation of Shh signaling. PMID: 26387942
13. Gli2 protein expression is downregulated during neural tube patterning, regulating Shh signaling. Shh-induced upregulation of Gli2 transcription prevents Gli activity levels from adapting in a different cell type. PMID: 25833741
14. Expression of Gli2A in T-cells altered gene expression profiles. PMID: 25908851
15. GLI2 binds to the IL-6Ralpha promoter and regulates its activity as well as the expression of this receptor. PMID: 26238488
16. The results uncover that both Shh/Gli2 and Shh/Gli3 signals are required for proper development of murine placentas and are possibly essential for pregnant maintenance. PMID: 25695606
17. While darinaparsin ameliorated fibrosis in WT and Gli1-KO mice, it was not effective in conditional Gli2-KO mice, supporting GLI2 as a direct darinaparsin target. PMID: 26193634
18. The ciliary localization of Gli2 is crucial for cilium-dependent activation of Hedgehog signaling. PMID: 25834022
19. Systematic analysis in ESCs reveals that distinct regions of Gli2 regulate its nuclear and ciliary localization. PMID: 24463817
20. The teratogenic effects of prenatal ethanol exposure are exacerbated by Sonic Hedgehog or GLI2 haploinsufficiency in the mouse. PMID: 24586787
21. Suggest a novel miR-326-negative feedback loop in regulating the activity of Shh/Gli/Smo signaling. PMID: 24617895
22. Phosphorylation at P1-6 sites determines Gli2 transcriptional activity. PMID: 24373970
23. Data suggests with that Gli2 may play a novel role in the self-renewal of pluripotent stem cells. PMID: 24121003
24. The sonic hedgehog-induced type 3 deiodinase facilitates tumorigenesis of basal cell carcinoma by reducing Gli2 inactivation. PMID: 24693967
25. PACAP blocks canonical Shh signaling by a mechanism that involves activation of protein kinase A (PKA) and inhibition of the translocation of the Shh-dependent transcription factor Gli2 into the primary cilium. PMID: 23872071
26. Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy. PMID: 23762415
27. Association with DNA-bound Pax3 strengthens the ability of both Zic1 and Gli2 to transactivate Myf5 in the epaxial somite. PMID: 24036067
28. Gli2, but not Gli3, is the major effector for hedgehog proteins signaling during intestine development. PMID: 23645682
29. we show that Hh signaling regulates Ndp expression in the developing retina and chromatin immunoprecipitation (ChIP) reveals Hh-dependent enrichment of Gli2 binding at the Ndp locus, suggesting that the relationship is direct PMID: 23201751
30. activation of Gli2 impairs bone formation in postnatal growing mice PMID: 23383082
31. These studies establish Sufu and Kif7 as crucial components in the regulation of Gli2 localization and activity, and illustrate their overlapping functions in skin development and tumor suppression. PMID: 23034632
32. Establishment of a complete range of anterior-posterior positional identities in the embryonic limb requires integration of the spatial distribution, timing, and dosage of GLI2 and GLI3 activators and repressors. PMID: 22841643
33. Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types. PMID: 22698544
34. SUMO modification inhibits GLI2 transcriptional activity by recruiting HDAC5. PMID: 22549777
35. Ascl1/Mash1 is a novel target of Gli2 during Gli2-induced neurogenesis in P19 EC cells PMID: 21559470
36. Results suggest functions of Shh-Gli signaling in sexually dimorphic development during embryogenesis. Shh expressed in urethral plate epithelium regulates genital tubercle differentiation through Gli2 in mesenchyme. (Shh = sonic hedgehog protein) PMID: 21586556
37. CCL5 signaling induces GLI2 through a PI3K-AKT-IkappaBalpha-p65 pathway and requires GLI2 transcriptional activity to modulate IL-6 expression and Ig secretion in vitro and in vivo PMID: 21454528
38. The proper balance between the Gli2 full-length activator and repressor is essential for Hh signaling. PMID: 21337666
39. ciliary localization of Sufu is dependent on ciliary-localized Gli proteins, and is inhibited by PKA activation PMID: 21209912
40. The hedgehog signaling pathway at vertebrate cilia cause dissociation of inactive SuFu-Gli complexes, a process inhibited by PKA. PMID: 20956384
41. Gli2, which encodes a major Gli activator, is required for proliferation of specific groups of pituitary progenitors but not for initial dorsoventral patterning. PMID: 20934421
42. Pias1-dependent SUMOylation influences Gli protein activity PMID: 20711444
43. primary cilia regulate the level of Hh activation, and that ablation of these cellular organelles is sufficient to cause significant up-regulation of the Hh pathway in pancreata of mice overexpressing GLI2 PMID: 20479231
44. changes in ciliary and nuclear trafficking of Gli2 are triggered by Hh-dependent accumulation of activated Smo in cilium, resulting in a shift from primarily cytoplasmic localization to accumulation at the distal tip of the cilium and within the nucleus PMID: 19996169
45. the Gli2 activator alone is sufficient to induce vascularization of the hypertrophic cartilage PMID: 19906844
46. Gli2 is required for mediating some of the inappropriate Shh signaling in Ptc mutants. Our studies demonstrate that, in mammals, Gli1 is not required for Shh signaling and that Gli2 mediates inappropriate activation of the pathway due to loss of Ptc. PMID: 12361967
47. Sonic hedgehog-dependent Gli2 activation plays a critical role in epithelial homeostasis by promoting proliferation through the transcriptional control of cell cycle regulators. PMID: 12533516
48. Gli2 and Gli3, mediators of Shh signaling, are required for the development of the ventral neural cell fates. PMID: 12812795
49. Gli2 plays an important role in regulating oligodendrocyte specification and differentiation in the caudal neural tube PMID: 12837627
50. Gli2 and Gli3 are required for Shh-dependent sclerotome induction. PMID: 14602680

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KEGG: mmu:14633

STRING: 10090.ENSMUSP00000054837

UniGene: Mm.273292