Recombinant Mouse Zinc finger protein Helios (Ikzf2)

1. These data provide a genetic basis for the unstable phenotype of Helios-deficient Tregs within the inflammatory environment of tumors and suggest that immune milieu-dependent alterations in gene expression are a central feature of Treg conversion. PMID: 29440380
2. He is involved in the correct development of a subset of striatopallidal medium spiny neurons. PMID: 28289129
3. Helios controls certain aspects of Treg-suppressive function, differentiation, and survival. PMID: 26582951
4. this study reports that impaired expression of the transcription factor Helios by FoxP3+ CD4 and Qa-1-restricted CD8 Tregs results in defective regulatory activity and autoimmunity in mice. PMID: 26472910
5. data suggest that a subset of DN T cells, identified by the expression of PD-1 and Helios, represent self-reactive cells; results provide an explanation for the origin of DN T cells and introduce CD8 loss as a process associated with self-Ag encounter PMID: 25825451
6. results demonstrate that Helios is expressed by thymic and peripheral T cells that are being driven to tolerance in response to a genuine autoantigen PMID: 24740292
7. identify Helios as the first marker known to diverge during positive and negative selection of thymocytes PMID: 23337809
8. Helios regulates IL-2 production in Tregs by suppressing Il2 gene transcription. Loss of Helios in Tregs breaks their anergic phenotype and results in derepression of the Il2 locus. PMID: 23275607
9. Helios expression spatially coincides with the early pattern of expression of the mature markers of striatal projection neurons. PMID: 22142223
10. In tumor-bearing mice, Helios(+) regulatory T cells were relatively over-represented in the tumor-mass. PMID: 22479644
11. Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions. PMID: 21918685
12. down-regulation of NK cell activity by NKp46 was associated with the silencing of the Helios transcription factor in NK cells PMID: 22267813
13. show that Helios is upregulated in CD4(+)CD25(+) regulatory T cells. PMID: 20226531
14. silencing of Helios is critical for normal B cell function PMID: 16148093
15. results demonstrate a vital function for Helios in maintaining normal homeostasis of developing T cells and formally show that non-DNA-binding isoforms of Helios are lymphomagenic if aberrantly expressed within the T-cell lineage PMID: 17110463
16. Helios is not essential for T cells; its function can be compensated for by other members of the Ikaros family. PMID: 19620299

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KEGG: mmu:22779

STRING: 10090.ENSMUSP00000027146

UniGene: Mm.106343