Recombinant Pig Dual oxidase 2 (DUOX2), partial

Code CSB-YP007229PI
MSDS
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Source Yeast
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Code CSB-EP007229PI
MSDS
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Source E.coli
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Code CSB-EP007229PI-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007229PI
MSDS
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Source Baculovirus
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Code CSB-MP007229PI
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
DUOX2
Uniprot No.
Alternative Names
DUOX2Dual oxidase 2; EC 1.11.1.-; EC 1.6.3.1; NADH/NADPH thyroid oxidase p138-tox
Species
Sus scrofa (Pig)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Gene References into Functions
  1. A novel recessive c.1226A>G transition of the dual oxidase 2 gene was identified as the causative mutation for a severe congenital hypothyroidism model together with anemia and T lymphopenia which mimics the clinical features of hypothyroid patients PMID: 28972010
  2. the dual oxidase 2 N-terminal region is targeted to the plasma membrane PMID: 15150274
  3. Expression along the length of the gastrointestinal tract. PMID: 15591162
Subcellular Location
Apical cell membrane; Multi-pass membrane protein. Cell junction.
Protein Families
Peroxidase family
Tissue Specificity
Expressed in thyroid, and the digestive tract especially in stomach, cecum and sigmoidal colon (at protein level). Expressed in thyroid.
Database Links

KEGG: ssc:397060

STRING: 9823.ENSSSCP00000005038

UniGene: Ssc.33

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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