Product Details

Purity

>85% (SDS-PAGE)

Target Names

NPPB

Uniprot No.

P07634

Alternative Names

NPPBNatriuretic peptides B; Gamma-brain natriuretic peptide) [Cleaved into: Brain natriuretic peptide 32; BNP-32); Brain natriuretic peptide 26; BNP-26)]

Species

Sus scrofa (Pig)

Expression Region

26-131

Target Protein Sequence

HPLGG AGLASELPGI QELLDRLRDR VSELQAERTD LEPLRQDRGL TEAWEAREAA PTGVLGPRSS IFQVLRGIRS PKTMRDSGCF GRRLDRIGSL SGLGCNVLRR Y

Protein Length

Full Length of Mature Protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.; Plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. In vivo, induces vasodilation.; May affect cardio-renal homeostasis. Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32.

Gene References into Functions

CNP and BNP serve as oocyte maturation inhibitor to inhibit oocyte maturation in mammals PMID: 24912131
ANP and BNP gene expression differs considerably between cardiac chambers in the first 72 hours of life in healthy piglets, resembling the transition from fetal to neonate circulation. The cardiac gene expression does not explain plasma concentrations. PMID: 23539511
Up-regulation of BNP and a reduction in a ratio of sarcoplasmic reticulum calcium ATPase 2a in failing myocardium are observed in a porcine model of tachycardia. PMID: 20880599
serum levels predict mortality in chest pain patients in Argentina PMID: 21958326
Data show that all five molecules, BNP, ICAM-1, TNF-alpha, VCAM-1 and IL-6, quickly and reliably signaled adverse interactions. PMID: 21471537
identification and characterization of a novel alternatively spliced variant of porcine and human NPPB resulting from exon 2 skipping PMID: 20660094
Arial natriuretic factor (ANF) and N-terminal proANF may be better suited than brain natriuretic peptide as markers of cardiac preload during the development and treatment of acute heart failure. PMID: 19361150
Regional differences in BNP and CNP expression were observed in myocardium with sustained left ventricular dyssynchronous contraction. PMID: 19540894

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Subcellular Location

Secreted.; [Brain natriuretic peptide 32]: Secreted.

Protein Families

Natriuretic peptide family

Tissue Specificity

Heart atrium.; [Brain natriuretic peptide 32]: Brain (at protein level).; [Brain natriuretic peptide 26]: Brain (at protein level).

Database Links

KEGG: ssc:396844

STRING: 9823.ENSSSCP00000003722

UniGene: Ssc.629

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Recombinant Pig Natriuretic peptides B (NPPB)

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