Recombinant Rat Alpha-1A adrenergic receptor(Adra1a),partial,Yeast

Code CSB-YP001385RA1
Size
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Product Details

Purity >85% (SDS-PAGE)
Target Names Adra1a
Uniprot No. P43140
Alternative Names Adra1a; Adra1cAlpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1A adrenoceptor; Alpha-1C adrenergic receptor
Species Rattus norvegicus (Rat)
Source Yeast
Protein Length full length protein
Tag Info N-terminal His-tagged
Tag-Free
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Data

Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
Gene References into Functions
  1. Chronic stress (water avoidance stress) animals present high levels of urinary noradrenaline, and we find the bladder dysfunctions in these animals are mediated by alpha 1A adrenoceptors, as Silodosin administration prevents the appearance of these alterations. PMID: 28569366
  2. effects of female sexual hormones on the expression and function of alpha1A- and alpha1D-adrenoceptor subtypes in the late-pregnant rat myometrium PMID: 26593425
  3. These findings indicated that noradrenaline activates alpha1-adrenoceptors, which were found to be the main receptors in Ca(2+)-related cell homeostasis and protein (including mucin) secretion in rats lacrimal glands. PMID: 26700590
  4. Silodosin, a selective alpha(1A)-adrenoceptor antagonist, improves voiding behavior in rat models with BOO by inducing recovery of bladder blood flow. PMID: 26189024
  5. Within 2 weeks of a burn, Adra1 expression increased in the re-forming epidermis, in dense bands of spindle-shaped cells in the upper dermis and on nerve fibres in the deep dermis. Adra1 expression in the upper dermis decreased contralateral to the burn. PMID: 25630693
  6. CXCR4 and ACKR3 modulate alpha1-AR reactivity in vascular smooth muscle and regulate hemodynamics in normal and pathological conditions PMID: 25032954
  7. Our data suggest that PKCalpha, beta and epsilon activation may underlie physiological and pathophysiological responses of alpha1-AR signaling for the phosphorylation of membrane-associated substrates including ion-channel and transporter proteins. PMID: 26277396
  8. heteromeric receptor complexes between alpha1A-AR and CXCR4 and between alpha1B-AR and CXCR4 are constitutively expressed in rat and human vascular smooth muscle cells; the quaternary structure of the receptor complex is important for signaling and contraction PMID: 25775528
  9. Data suggest an important role of alpha1 adrenoceptor autoimmunity in the pathogenesis and management of hypertension especially in those harboring high alpha1-AA levels. PMID: 24950619
  10. In conclusion, Gq protein-coupled alpha1 adrenergic receptors evoke pMF, but they are not necessary for AIH-induced pLTF. PMID: 24526581
  11. Our findings indicate that IC noradrenergic neurotransmission acting through activation of both alpha1- and alpha2-adrenoceptors has a facilitatory influence on pressor response to acute restraint stress. PMID: 24404141
  12. In the frontal cortex during sleep deprivation, adrenergic alpha1 receptor mRNA levels were reduced. PMID: 23916734
  13. This study demonistrated that expression of alpha(1)-adrenergic receptors in rat prefrontal cortex and collozation with 5-HT(2A) receptors. PMID: 23195622
  14. Local alpha-1 adrenergic receptors control dopamine transmission in the medial nucleus accumbens shell and behavioral responses to drugs of abuse. PMID: 22588352
  15. Both alpha1- and beta1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear PMID: 22506532
  16. Hypothermia attenuates alpha1-adrenoceptor-mediated contraction or decreases Phe sensitivity and effective maximal vasocontraction. PMID: 22504059
  17. The noradrenergic component of the action of antidepressant agents plays an essential role in the modulation of alpha1A-adrenoceptor subtype in the rat cerebral cortex. PMID: 22358083
  18. Presynaptic alpha1-adrenoreceptors (alpha1-AR) activation modulates glutamatergic inputs that affect ventral tegmental area-dopamine neuronal excitability. PMID: 22542873
  19. Transcriptionally, however, second window preconditioning is considerably more complex than alpha(1A)-TG preconditioning PMID: 22307672
  20. Expression of alpha1-adrenoceptors on C- and delta-nociceptive afferent fibers provides a histochemical substrate for direct excitation of these fibers by adrenergic agonists. PMID: 21182905
  21. alpha- and beta-adrenergic signalling has a role in epinephrine-dependent control of glucose metabolism in white adipose tissue PMID: 22302710
  22. The alpha(1)-adrenergic stimulation releases Rem1 inhibition of voltage-gated L-type calcium channels through direct phosphorylation of Rem1 at Ser18 by protein kinase D1, resulting in an increase of the channel activity and transverse-tubule expression. PMID: 22076634
  23. NOX2 activated by alpha1-adrenoceptors modulates hepatic metabolic routes stimulated by beta-adrenoceptors PMID: 21958220
  24. Fructose intake raised the contribution of alpha1A-adrenoceptor subtype in mediating adrenergically induced vasoconstriction. PMID: 21373947
  25. CREB-mediated expression of alpha1 adrenoceptor contributes to TBI-associated working memory dysfunction, and therapies aimed at reducing alpha1 signaling may be useful in the treatment of TBI-associated WM deficits in humans. PMID: 20974230
  26. The noradrenaline-mediated depolarization of vascular smooth muscle cells is produced by activation of both alpha(1)-and alpha(2)-adrenoceptors. PMID: 20739228
  27. Ca(2+) entry via the Adra1a-Snapin-TRPC6-pathway plays an important role in physiological regulation of cardiac contractility and may be an important target for augmenting cardiac performance. PMID: 21546445
  28. Adrenergic alpha1 receptor mediates contractions of thoracic aorta by transactivation of epidermal growth factor receptor. PMID: 20977469
  29. Results show that microinjection of noradrenaline into the accumbens of conscious rats activates local alpha-adrenoceptors, evoking pressor and bradycardic responses, which are mediated by vasopressin release. PMID: 21535246
  30. Supraspinal alpha(1A)- and alpha(1D)-adrenergic receptors are apparently important for the regulation of reflex-bladder activity in conscious rats. PMID: 20668103
  31. alpha(1)-AR agonists contribute to hypertrophic remodelling of cardiac myocytes PMID: 19685172
  32. There was a functional coexistence of alpha(1A)- and alpha(1D)-adrenoceptors in the renal vasculature of spontaneously hypertensive rats irrespective of the presence of diabetic nephropathy. PMID: 19844130
  33. The alpha 1A-adrenoceptor subtype is specifically involved in the mechanism of action of classical antidepressant treatments (electroconvulsive shock and repeated imipramine). PMID: 12063075
  34. cloning and characterization of promoter and demonstration of cell specificity and regulation by hypoxia PMID: 12471020
  35. known second messenger, mitogenic, and transcriptional effects of alpha1A-adrenergic receptors in PC12 cells all require G protein activation. PMID: 12724349
  36. gene expression of alpha(1A)-AR is increased in the prostate of diabetic rats PMID: 12784082
  37. Results suggest that the uterine smooth muscle contraction increase caused by serotonin is mediated by adrenergic alpha(1A) receptors. PMID: 12837924
  38. alpha1-adrenergic activation of gene expression in cardiac myocytes is regulated by Vgl-4 PMID: 15140898
  39. Data suggest that alpha(1)-adrenoceptor stimulation reduces the amplitude of the I(to) by activating a G(alphas) protein and the cAMP/PKA signaling cascade, which in turn leads to I(to) channel phosphorylation. PMID: 15496483
  40. alpha1-adrenoceptors mediate increases in glucose uptake in L6 muscle cells. PMID: 15550506
  41. Human ureter was endowed with each alpha1 AR subtype, although alpha1D and alpha1A ARs were prevalent over alpha1B ARs. PMID: 15690361
  42. Hsp72 increases in the circulation via an alpha1-adrenergic receptor-mediated signaling pathway PMID: 16037404
  43. three subpopulations of alpha1-adrenoceptor binding sites exist in the rat lung (alpha1A, alpha1B and alpha1D) PMID: 16308429
  44. These results indicate that RGS2 is an important negative-regulatory factor in cardiac hypertrophy produced by alpha1-adrenergic receptor stimulation through mechanisms involving the modulation of mitogen-activated protein kinase signaling pathways. PMID: 16517124
  45. This study suggests that: (i) alpha(1A) and alpha(1D)-adrenoceptor subtypes mediate vasoconstriction of perfused rat kidney. Ageing significantly decreases alpha1-adrenoceptor-mediated vasoconstriction of rat kidney. PMID: 17199872
  46. This study indicates the alpha1-adrenergic receptor subtype mediates adrenergic augmentation of the activation of sensory nerves by purinergic P2X3 receptors (respond to ATP) in the periphery. PMID: 17512257
  47. Akap1 signaling complex mediates Adra1a-induced cardiomyocyte hypertrophy. PMID: 17537920
  48. These results indicate that alpha 1-adrenergic stimulation of intracellular Ca2+ activity is mediated selectively by the alpha 1A-AR. PMID: 17588332
  49. alpha(1)-AR in afferent cell bodies in the spiral ganglion pointed to type I afferent dendrites as a possible neural source of alpha(1)-AR beneath the inner hair cell. PMID: 17671986
  50. RT-PCR studies indicated differential distribution of all ADRA1A-related splice variants as well as ADRA1B and ADRA1D mRNAs, in tissues from rhesus and human male reproductive tract. PMID: 18204069

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Subcellular Location Nucleus membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein, Cytoplasm, Membrane, caveola
Protein Families G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA1A sub-subfamily
Tissue Specificity Abundant in heart, brain, aorta, vena cava, vas deferens, submaxillary gland, lung, and kidney. Found at lower levels in prostate, parotid gland and skeletal muscle.
Database Links

KEGG: rno:29412

STRING: 10116.ENSRNOP00000012736

UniGene: Rn.9991

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