Recombinant Rat Alpha-1A adrenergic receptor(Adra1a)

Code CSB-CF001385RA
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P43140
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Rattus norvegicus (Rat)
Sequence MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
Source in vitro E.coli expression system
Gene Names Adra1a
Protein Names Recommended name: Alpha-1A adrenergic receptorAlternative name(s): Alpha-1A adrenoreceptor Short name= Alpha-1A adrenoceptor Alpha-1C adrenergic receptor
Expression Region 1-466
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
Subcellular Location Nucleus membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein, Cytoplasm, Membrane, caveola
Protein Families G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA1A sub-subfamily
Tissue Specificity Abundant in heart, brain, aorta, vena cava, vas deferens, submaxillary gland, lung, and kidney. Found at lower levels in prostate, parotid gland and skeletal muscle.
Database Links

KEGG: rno:29412

STRING: 10116.ENSRNOP00000012736

UniGene: Rn.9991

Pathway Calcium signaling pathway
Vascular smooth muscle contraction
AMPK signaling
cGMP-PKG signaling pathway

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