Recombinant Rat B2 bradykinin receptor(Bdkrb2),partial,Mammalian cell

Code CSB-MP002652RA1
Size
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Product Details

Purity >85% (SDS-PAGE)
Target Names Bdkrb2
Uniprot No. P25023
Alternative Names Bdkrb2B2 bradykinin receptor; B2R; BK-2 receptor
Species Rattus norvegicus (Rat)
Source Mammalian cell
Protein Length Partial
Tag Info N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Data

Function Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Gene References into Functions
  1. Findings suggest that bradykinin 1 receptor and bradykinin 2 receptor have detrimental and beneficial effects, respectively in diabetic cerebral ischaemia. PMID: 26565562
  2. Up-regulation of the kinin B2 receptor pathway modulates the TGF-beta/Smad signaling cascade to reduce renal fibrosis induced by albumin. PMID: 26256678
  3. These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness. PMID: 25713410
  4. B2R signaling may regulate monocyte/macrophage infiltration and c-Jun signals in the irradiated heart. Although eNOS is a main target for kinins, the B2R may not regulate eNOS phosphorylation in response to radiation. PMID: 25955317
  5. bradykinin receptor B1 may participate in apoptotic cell death signalling, and bradykinin receptor B2 may be involved in necrotic cell death PMID: 24724708
  6. Data indicate that ANO1 channels form signaling complexes with IP3 receptor (IP3R1) and GPCRs bradykinin receptor 2 (B2R) and protease-activated receptor 2 (PAR-2). PMID: 23982204
  7. The neuroprotective feature of bradykinin stimulates the kinin-B2 receptor (B1BKR), providing a novel understanding of the physiological roles of these receptors. PMID: 23735753
  8. the role of bradykinin B2 receptor in vascular endothelium and it's regulation by bradykinin B1 receptor PMID: 23306173
  9. Data suggest that expression of Bdkrb2 is up-regulated in adrenal medulla as the result of stress (here, immobilization stress); data from rats with pharmacological adrenalectomy suggest this up-regulation requires adrenomedullary glucocorticoids. PMID: 24025224
  10. Heightened bradykinin B2 receptor expression in the sensory nerves contributes to the exaggerated muscle mechanoreflex in rats with femoral artery occlusion. PMID: 23417862
  11. Data show the important roles of B1 and B2 bradykinin receptors in overactive urinary bladder syndrome (OAB) following spinal cord injury in rats and suggest that blockade of these receptors could be a therapeutic target for controlling OAB PMID: 22862305
  12. Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. PMID: 23132855
  13. Observations demonstrate a novel role of plasma kallikrein and bradykinin activation in the synovial recruitment of endothelial stem cells in arthritis, acting via kallikrein activation and B2R-dependent mechanisms. PMID: 22739815
  14. Our study suggests that hyperglycemia induces apoptosis via the stimulation of B1R and B2R expression through CB1R activation in rat podocytes in vitro PMID: 22877648
  15. Aging cardiac endothelial cells gradually lose their capacity to express BK-2Rs. PMID: 21986469
  16. In the medulla, chronic exercise could hyperstimulate the kallikrein-kinin system enhancing its efficiency via the increase of bradykinin B2 receptor density, involving this receptor in central cardiovascular control during exercise or stress. PMID: 20637711
  17. expression of KLKI and B2R changed in an age-dependent pattern in the corpus cavernosum and have a tendency to decline during ageing PMID: 20345876
  18. Tanshinone IIA is cardioprotective in the context of diabetic cardiomyopathy through kinin B2 receptor-Akt-GSK-3beta dependent pathway. PMID: 21232147
  19. Data suggest that spinal dynorphin may maintain pancreatitis pain through direct or indirect activation of BK B2 receptors in the spinal cord. PMID: 20531238
  20. The structure of the rat kinin B2 receptor gene (KB2r) and encoding messenger RNA (mRNA) processing, was examined. PMID: 20198577
  21. Although B2BKR expression was not altered in the middle cerebral arteries of spontaneously hypertensive rats after hypertensive encephalopathy or cerebral hemorrhage, bradykinin-mediated relaxation was abolished. PMID: 19954757
  22. in normal rat knee joints, PAR4 activation increases joint primary afferent activity in response to mechanical stimuli. This PAR4-induced sensitization is TRPV1-independent but involves B2 receptor activation, suggesting a role for kinins in this process PMID: 19889854
  23. Data show that bradykinin-induced plasma extravasation is mediated by bradykinin B2 receptors and is inhibited by nociceptin. PMID: 19544046
  24. MEDIATES the formation of vasogenic brain edema in rats PMID: 11686492
  25. Upregulation of kinin B2 receptor mRNA in the hypothalamus of spontaneously hypertensive rats from early age may participate in the pathogenesis of hypertension. PMID: 12025958
  26. Activation of bradykinin 2 receptor negatively modulates the phosphorylation of Erk1 and Erk2 induced by insulin-like growth factor-1, platelet-derived growth factor-BB, and high glucose in the kidney glomerulus. PMID: 12025970
  27. the cell-specific regulation of the BKB2 receptor and the importance of a silencer element present in the regulatory region of the gene. PMID: 12435802
  28. results demonstrated a stage-specific expression of the bradykinin B(2) receptor in different cells of the seminiferous tubules of the rat testis PMID: 12444060
  29. Up-regulation of bradykinin B2-receptor in early stages of cardiac wound healing induced by ischemia and in chronic stages of cardiac remodeling indicates that kinins play a major role in the complex processes of cardiac tissue injury and repair PMID: 12489796
  30. findings suggest that bradykinin B2 receptor is involved in mediating the stimulatory effect of bradykinin on pro-spermatogonial cell proliferation PMID: 12558524
  31. stage-dependent specific expression of tissue kallikrein and bradykinin B2 receptors in developing germ cells and peritubular cells suggests a potential role in the local regulation of spermatogenesis PMID: 12558526
  32. Down-regulation of bradykinin B2-receptor mRNA in the heart in pressure-overload cardiac hypertrophy in the rat. PMID: 12623134
  33. increased bradykinin B(2) receptor expression in the hypothalamus and adrenal glands may play a role in the abnormalities of the hypothalamo-pituitary-adrenal axis during the development of hypertension PMID: 12639805
  34. Effects of angiotensin II on cell differentiation and cyclic GMP production were mediated via the AT2 receptor and further enhanced by bradykinin B2 receptor blockade PMID: 12694402
  35. Kindling-induced epilepsy results in a significant decline of B(2) receptor binding sites in the rat brain. An altered balance between B(1) and B(2) receptor populations may play a pivotal role in the onset and/or maintenance of epilepsy. PMID: 12746865
  36. there are two functionally divergent p53-responsive elements in the rat bradykinin B2 receptor promoter PMID: 12791684
  37. ongoing pressure overload leads to a loss of BK-2Rs with a dramatic increase in left ventricular fibrosis followed by diastolic dysfunction and heart failure. PMID: 12923406
  38. Mediator role of bradykinin in ischemic brain damage including edema formation, obviously by ligand binding to bradykinin B2 receptor. Receptor antagonist may be treatment in stroke patients. PMID: 14753436
  39. Angiotensin II regulates expression of B2KR in vascular smooth muscle cells PMID: 14766673
  40. B2 receptor activation promotes synovial endothelial cell proliferation in acute synovitis. PMID: 14766794
  41. B1R & B2R signaling show physiologic antagonism. B2R antagonism decreased leukocyte & synovial CD44 & CD54 & endothelial CD11b expression, implicating B2R in the acute phase of inflammation by facilitating leukocyte activation, homing, & transmigration. PMID: 15001555
  42. These studies demonstrate that urothelial expression of bradykinin receptors is plastic and is altered by pathology. PMID: 15576455
  43. phospholipase C (PLC)gamma1 can interact with the immunoreceptor tyrosine-based inhibition motif (ITIM) sequence located in the C-terminal part of the bradykinin B2 receptor; interaction was only observed in quiescent and not in proliferating cells PMID: 15607753
  44. Age-related decreases in bradykinin B2 receptor may leave heart vulnerable to ischemic damage, and increases in bradykinin B1 receptor may represent compensatory reaction in aging hearts. PMID: 15708952
  45. In conclusion, the findings from this study indicate that exercise training alters the localization of FAT/CD36 and increases its association with CPT I, which may help augment fat oxidation. PMID: 16507603
  46. after hepatic ischemia, angiotensin-converting enzyme (ACE) inhibition reduced reperfusion injury in a bradykinin-2-receptor-dependent manner PMID: 16513137
  47. We report the distance between the AT2R and B2R in PC12W cell membranes to be 50+/-5 A, providing evidence and quantification of receptor heterodimerization as the mechanism for enhancing NO production PMID: 16754789
  48. Implication of both kinin B1 and B2 receptors in thermal hyperalgesia but not in tactile and cold allodynia associated with peripheral nerve injury. PMID: 18182225
  49. Results show that plasma membrane and highly purified nuclei from isolated rat hepatocytes contain specific bradykinin B2 receptors that bind bradykinin. PMID: 18264983
  50. kinin-B2 receptors and BK secretion indicate an autocrine loop during neurosphere differentiation to neurons, astrocytes, and oligodendrocytes, reflecting events occurring during early brain development PMID: 18302192

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family, Bradykinin receptor subfamily, BDKRB2 sub-subfamily
Tissue Specificity Uterus, vas deferens, kidney, ileum, heart, testis, lung and brain.
Database Links

KEGG: rno:25245

STRING: 10116.ENSRNOP00000064990

UniGene: Rn.9845

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