Recombinant Rat Allograft inflammatory factor 1(Aif1)

Code CSB-EP001490RA
Product Type Recombinant Protein
Size US$2466
Uniprot No. P55009
Relevance Actin-binding protein that enhances mbrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play an role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation .
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Ionized calcium-binding adapter molecule 1;MRF-1;Microglia response factor
Species Rattus norvegicus (Rat)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence SQSKDLQGGKAFGLLKAQQEERLDGINKHFLDDPKYSSDEDLQSKLEAFKTKYMEFDLNGNGDIDIMSLKRMLEKLGVPKTHLELKKLIREVSSGSEETFSYSDFLRMMLGKRSAILRMILMYEEKNKEHQKPTGPPAKKAISELP
Research Area Neuroscience
Source E.coli
Gene Names Aif1
Protein Names Recommended name: Allograft inflammatory factor 1 Short name= AIF-1 Alternative name(s): Ionized calcium-binding adapter molecule 1 MRF-1 Microglia response factor
Expression Region 2-147aa
Tag Info N-terminal 6xHis-SUMO-tagged
Mol. Weight 32.7kDa
Protein Description Full Length of Mature Protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play an role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity).
Subcellular Location Cytoplasm, cytoskeleton, Cell projection, ruffle membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, phagocytic cup
Tissue Specificity Cardiac allograft, spleen and testis. Expressed by inflammatory cells (macrophages and neutrophils).
Database Links

KEGG: rno:29427

STRING: 10116.ENSRNOP00000001138

UniGene: Rn.32080

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