Recombinant Rat Atrial natriuretic peptide receptor 1 (Npr1), partial

1. Atenolol treatment normalized the altered expression of Npr1 and Npr2 genes. PMID: 27283501
2. Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in cardiomyocytes in vitro. PMID: 28743500
3. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis. PMID: 26934489
4. BNP and NPR-A are expressed in the dorsal horn ganglion, and expressions are elevated in rats with chronic nonbacterial prostatitis. PMID: 22474982
5. knockdown of NPR-A up-regulates the expression of NPR-C, Gialpha proteins, and NPR-C-linked adenylyl cyclase signalling and suggests a cross-talk between NPR-A and NPR-C. PMID: 22131352
6. speculate that, in NPRA, the ANP-induced rotation of the juxtamembrane domains, transmitted across the transmembrane helices, may induce a similar rotation in each of the dimerized GC catalytic domains, leading to the stimulation of GC catalytic activity PMID: 21375693
7. activation of hypothalamic natriuretic peptide receptor-A in rat has a role in inhibition of dehydration-induced water intake by glucocorticoids PMID: 21187974
8. Seven sites of phosphorylation were identified in rat GC-A (S497, T500, S502, S506, S510, T513, and S487), and all of these sites except S510 and T513 were observed in human GC-A. PMID: 20977274
9. The two natriuretic peptide receptors, guanylyl cyclase-A (GC-A) and GC-B are subject to pronounced size alterations in the rat brain between postnatal day 1 and adult. PMID: 20880010
10. results demonstrate that NPRs are clearly expressed in the cells located in the ganglion cell layer including the three major subtypes of retinal ganglion cells and the expression is mainly on the membrane of somata PMID: 20304036
11. A new molecular model is proposed for NPRA's active conformation in which the juxtamembrane and transmembrane regions are taken into account before and after receptor activation. PMID: 20214400
12. These findings support roles for NPR-A, the common receptor of atrial (ANP) and B-type (BNP) natriuretic peptide in mature neurons and provide evidence for pronounced changes in neuronal submembrane cGMP signalling during neuronal differentiation. PMID: 20097258
13. Study revealed that GC-B predominates in the developing and GC-A in the adult brain, with regional differences each between cerebral cortex, cerebellum, and brain stem. PMID: 19837875
14. activation of NPRA in relation to eNOS expression in renal medulla cells PMID: 12082097
15. there are altered NPR-A receptors in rat spontaneously hypertensive kidney, which might act as a negative feedback in response to hypertension PMID: 12217425
16. A repetitive dinucleotide polymorphism of the Npr1 promotor alters the transcription of the Npr1 gene with consequences on blood pressure in spontaneously hypertensive rats. PMID: 12511524
17. NPRA-PKG association may have a role in compartmentation of cGMP-mediated signaling and regulation of receptor sensitivity PMID: 12855709
18. NPRA receptor has a role in attenuating the effects of hypertrophic agents on cardiac wall thickness and in cardiac hypertrophy PMID: 14500707
19. seminiferous tubules rather than Leydig cells are the predominant GC-A expression sites in the rat testis and functional activity was proved by ANP- induced cGMP accumulation in isolated seminiferous tubules. PMID: 14630722
20. natriuretic peptide receptor type A has a role in patterning of renal cGMP production PMID: 15093696
21. The cGMP regulatory region is at position -1372 to -1354 from the transcription start site of Npr1. Cross-competition experiments with mutated oligonucleotides led to the definition of a consensus sequence (-1372 AaAtRKaNTTCaAcAKTY -1354). PMID: 15096467
22. ANF stimulates renal dopamine uptake through natriuretic peptide-type A receptor PMID: 15544851
23. The data suggest that pressure overload is accompanied by upregulation of not only ANP and BNP but also their receptors NPR-A and NPR-C in the left ventricle. PMID: 16272201
24. this is the first study that explores the effect of extracellular Ca+ on ATP-mediated regulation of NPR-A-coupled guanylyl cyclase in renal glomeruli PMID: 17033090
25. Increase in natriuretic peptide receptor-A expression may account for some of the reported beneficial effect of 1,25(OH)(2)D3 on the cardiovascular system and kidney. PMID: 17440494
26. our results suggest the existence of a local and complex peptidergic system in the rat testis, involving ANP and its receptors that could importantly modulate the androgen biosynthesis. PMID: 18778744
27. BNP was capable of inhibiting VSMCs proliferation by NPRA/cGMP pathway PMID: 19104909
28. protein structure studies showed the fold of the ligand binding domain is that of a bilobal periplasmic binding protein (PBP), which is used in multi-domain receptors/proteins PMID: 11556325

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KEGG: rno:24603

STRING: 10116.ENSRNOP00000020307

UniGene: Rn.10463