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Recombinant Rat CMRF35-like molecule 1 (Cd300lf),Partial

Recombinant Rat CMRF35-like molecule 1 (Cd300lf),Partial

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Code	CSB-EP707077RA
Abbreviation	Recombinant Rat Cd300lf protein, partial
MSDS	MSDS Datasheet
Size	US$388
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP707077RA could indicate that this peptide derived from E.coli-expressed Rattus norvegicus (Rat) Cd300lf. Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP707077RA could indicate that this peptide derived from E.coli-expressed Rattus norvegicus (Rat) Cd300lf.
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Product Details
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Target Background

Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

Cd300lf

Uniprot No.

Q566E6

Research Area

others

Alternative Names

Cd300lf; Clm1CMRF35-like molecule 1; CLM-1; CD300 antigen-like family member F; CD antigen CD300f

Species

Rattus norvegicus (Rat)

Source

E.coli

Expression Region

19-181aa

Target Protein Sequence

AQDPVTGPEEVSGYEQGSLTVWCRYGSWWKDYSKYWCRGPKRSSCEIRVETDASERLVKENHVSIRDDQTNFTFTVTMEDLRMSDAGIYWCGITKAGYDHMFKVHVSINPVPTTPTTTSTTTIFTVTTTVKETSTLSTQTSHYSDNRYDSGGVGDGNGFLDLS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

38.3kDa

Protein Length

Extracellular Domain

Tag Info

N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

Our Recombinant Rat CMRF35-like molecule 1 (CLM-1) is a product carefully crafted to enhance your research endeavors. The CD300f protein encoded by the 'Cd300lf' gene is a member of the CD300 antigen-like family, functioning as a crucial part of immune responses. Expressed from Rat species, this protein offers the opportunity to explore different facets of immunological research.

Our protein is obtained from E.coli, and is tailored to cover the extracellular domain with an expression region of 19-181 amino acids, capturing the key functional domains. To enhance its usability, our protein is labeled with a N-terminal 10xHis-SUMO tag and a C-terminal Myc tag, providing ease in purification and detection. With purity greater than 90% as determined by SDS-PAGE, you can be assured of the product's reliability. We offer the Recombinant Rat CD300f protein in two different formats - liquid or lyophilized powder, catering to diverse experimental conditions.

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Target Background

Function

Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

CD300 family

Database Links

KEGG: rno:287818

STRING: 10116.ENSRNOP00000033887

UniGene: Rn.130740

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