Recombinant Rat Carboxypeptidase B2 (Cpb2)

Code CSB-YP872122RA
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP872122RA
MSDS
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Source E.coli
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Code CSB-EP872122RA-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP872122RA
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP872122RA
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Cpb2
Uniprot No.
Alternative Names
Cpb2Carboxypeptidase B2; EC 3.4.17.20; Carboxypeptidase R; CPR; Carboxypeptidase U; CPU; Thrombin-activable fibrinolysis inhibitor; TAFI
Species
Rattus norvegicus (Rat)
Expression Region
114-422
Target Protein Sequence
ASSSYYE QYHSLNEIYS WIEVITEQHP DMLQKIYIGS SYEKYPLYVL KVSGKEHRVK NAIWIDCGIH AREWISPAFC LWFIGYVTQF HGKENTYTRL LRHVDFYIMP VMNVDGYDYT WKKNRMWRKN RSVHMNNRCV GTDLNRNFAS KHWCEKGASS FSCSETYCGL YPESEPEVKA VADFLRRNIN HIKAYISMHS YSQQILFPYS YNRSKSKDHE ELSLVASEAV RAIESINKNT RYTHGSGSES LYLAPGGSDD WIYDLGIKYS FTIELRDTGR YGFLLPERFI KPTCAEALAA VSKIAWHVIR NS
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
Gene References into Functions
  1. Results indicate that TAFIa could be a novel biomarker and realistic therapeutic target of chronic thromboembolic pulmonary hypertension. PMID: 28289017
  2. Thrombin-activatable fibrinolysis inhibitor is activated in an instant blood-mediated inflammatory reaction after intraportal islet transplant. PMID: 24188431
  3. Carboxypeptidase B2 and complement C3 were more abundant in the cerebrospinal fluid of experimental autoimmune encephalomyelitis rats that did not respond to minocyline treatment. PMID: 22768796
  4. Arterial, platelet-rich thrombi in vivo are degraded by naturally generated plasminogen activators. TAFI may play a significant role in the control of these mechanisms. PMID: 11848438
  5. an increase in circulating TAFIa impairs endogenous clot lysis in a rat model of fibrin deposition PMID: 12958609
  6. the region comprising alpha-helix 9 and beta-sheet 11 contributes to both human and rat TAFIa stability PMID: 18513211
  7. TAFI regulates plasmin activity through its enzymatic activity whereby it reduces the plasminogen-binding capacity of the hepatocytes; gene expression is down-regulated in hepatocyte proliferation for producing a fibrinolytic environment for cell growth PMID: 19386599

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Subcellular Location
Secreted.
Protein Families
Peptidase M14 family
Tissue Specificity
Plasma; synthesized in the liver.
Database Links
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