Recombinant Rat Caveolin-2(Cav2)

Code CSB-YP645342RA
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Source Yeast
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Code CSB-EP645342RA
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Source E.coli
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Code CSB-EP645342RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP645342RA
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Source Baculovirus
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Code CSB-MP645342RA
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Cav2
Uniprot No.
Alternative Names
Cav2Caveolin-2
Species
Rattus norvegicus (Rat)
Expression Region
1-162
Target Protein Sequence
MGLETEKADV QLFMADDAYS HHSVVDYTDP EKYVDSSQDR DPHQLNSHLK LGFEDLIAEP PTTHSFDKVW ICSHALFEIS KYVIYKFLTV FLAIPLAFIA GILFATLSCL HIWILMPFVK TCLMVLPSVQ TIWKSVTDVV IGPLCTSVGR IFSSVSMQLS HD
Protein Length
full length protein
Tag Info
The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
Gene References into Functions
  1. The localisation and expression of caveolin 2 in luminal uterine epithelium at the time of implantation suggest a role in trafficking proteins and the maintenance of a polarised epithelium. PMID: 24953158
  2. show that Cav-2 is an epigenetic regulator of histone H3 modifications, and provide novel mechanisms of insulin-response epigenetic activation at the nuclear periphery PMID: 25753664
  3. Cav2 translocates to inner nuclear membrane in response to insulin via Rab6 mediated pathway. PMID: 22607032
  4. caveolin-2 protein expression and immunoreactivity were reduced in bladder smooth muscle at 6 and 12 months of age compared with young animals. PMID: 22374691
  5. Insulin-activated extracellular signal-regulated kinase (ERK) is translocated to the nuclear envelope by caveolin-2. PMID: 20455999
  6. The phosphorylation of tyrosine 19-caveolin-2 is required for actin cytoskeleton-dependent ERK nuclear import. PMID: 19778377
  7. lipid raft-dependent tyrosine phosphorylation of caveolin-2 may be a critical regulator of P. aeruginosa invasion PMID: 15545264
  8. Caveolin-2 is expressed constitutively in vascular endothelial cells and ependymal cells of normal rat spinal cord; the expression level begins to increase when experimental autoimmune encephalitis is initiated. PMID: 15925413

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Subcellular Location
Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Protein Families
Caveolin family
Tissue Specificity
In the retina, mainly expressed in vessels, but also diffuse expression in the inner and outer plexiform layers and in the inner nuclear layer.
Database Links
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
Address
7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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