Recombinant Rat Delta-type opioid receptor (Oprd1), partial

1. DOR1 and DOR2 subtype selective ligands can act differentially on individual ventral tegmental area (VTA) neurons and that when both are expressed in a single neuron the postsynaptic response to one does not predict the presence or valence of the response to the other. DOR subtypes not only differentially control individual neurons, but also modulate different, partially overlapping, subpopulations of VTA neurons. PMID: 28645621
2. Hypoxia significantly modifies the miRNA profile in the liver, while opioid receptor delta activation can modify the hypoxic modification. PMID: 29262398
3. these results expand the known function of GRK2, identifying a non-internalizing role to maintain peripheral DOR in an analgesically incompetent state. PMID: 27568556
4. Results from this study demonstrate the convergence of three important systems, norepinephrine, corticotropin-releasing factor, and delta opioid receptors, in the amygdala and provide insight into their functional role in modulating stress and anxiety responses. PMID: 27376372
5. Results suggest that mu opioid receptor-induced suppression of excitatory propagation in the insular cortex is an underlying mechanism of the powerful analgesic effects of mu opioid receptor agonists. In contrast, delta opioid receptors may play a minor role in suppressing acute pain. PMID: 27246300
6. After IR, the delta-opioid receptor may mediate, in part, cardioprotection against necrosis but not apoptosis. PMID: 25639363
7. delta-Opioid receptors in the accumbens shell mediate the influence of both excitatory and inhibitory predictions on choice PMID: 24758591
8. Specific agonism of DOR-1 induces place preference in ethanol-drinking animals. PMID: 24033469
9. Our data demonstrate that mu-delta heteromer signaling does not desensitize and is regulated differently from mu- and delta-receptor signaling following prolonged morphine treatment. PMID: 24976397
10. Data indicate that delta-opioid receptor (DOR)activation rescues TrkB signaling by reversing ischemia/reperfusion induced decrease in the full-length TrkB receptor and reduces brain injury in ischemia/reperfusion. PMID: 23844255
11. Activation of delta and mu opioid receptors relieves pain induced both mechanically and by heat. PMID: 23843537
12. The delta2 opioid receptor plays a key role in preventing cardiomyocytes from apoptosis during hypoxia/reoxygenation injury. PMID: 22592774
13. CB(1)R-DOR heteromers have a role in altered cortical function of DOR during neuropathic pain PMID: 23272051
14. analysis of delta-opioid receptor activation and microRNA expression of the rat cortex in hypoxia PMID: 23272113
15. In the corpus striatum, signaling capabilities of delta opioid receptor are linked to changes in CB1 receptor or dopamine D2 receptor. PMID: 23286559
16. Unlike delta-opioid receptors, activated mu- opioid type are partly capable of turning pulmonary C-fiber-mediated, rapid-shallow breathing rats into an appneic state. PMID: 22796630
17. delta-opioid transmission modulates the expression of L-DOPA (dopamine)-induced dyskinesias in rodents; the delta-opioid receptors involved in this effect are located on terminals of corticostriatal neurons. PMID: 22575599
18. the expression of delta opioid receptor in the rat brain is upregulated by hypoxia-inducible factor-1alpha following exposure to 7-day hypoxic preconditioning PMID: 22200548
19. data suggest that DOR-KOR heteromers exist in rat primary sensory neurons and that KOR antagonists can act as modulators of DOR agonist responses most likely through allosteric interactions between the protomers of the DOR-KOR heteromer PMID: 22072818
20. These data support the role of the delta-opioid receptor in the regulation of mood, and suggest that AZD2327, a highly selective delta-opioid receptor agonist, may possess unique antidepressant and anxiolytic activities. PMID: 21444630
21. JWA is required for maintaining the stability of DOR via the ubiquitin-proteasome pathway in chronic morphine dependence. PMID: 21600884
22. Direct control of opioids via delta-receptors(DOR) occurs on GnRH neurons and validates use of GT1 cells to further investigate nature of DOR present on GnRH neurons. (Delta receptor, GnRH) PMID: 16405927
23. Data suggest that the cardiac opioid system and delta opioid receptor regulate neonatal and adult heart function through the autonomic nervous system. PMID: 21280046
24. Data suggest that multiple reproductive experiences influence both gene activity and kappa, mu, and delta opioid receptor expression in the periaqueductal gray. PMID: 20574683
25. Provide direct evidence that activation of DOR in the central amygdala reduces anxiety-like behavior and suggest that DOR in this area are important for regulating anxious states. PMID: 20730419
26. These findings demonstrate that delta-opioid receptor activation selectively inhibits inputs activated by icilin, whereas mu-opioid receptor activation has a more widespread effect on synaptic inputs to neurons in the superficial dorsal horn. PMID: 20977770
27. Coexistence of delta-opioid receptors and mu-opioid receptors in small dorsal root ganglia neurons is a basis for direct interaction of opioid receptors in modulation of nociceptive afferent transmission and opioid analgesia. PMID: 20615975
28. p300 is dynamically associated with the dor gene. PMID: 20399742
29. Electroacupuncture can up-regulate delta-opioid receptor and protect the brain from ischemia-reperfusion injury. PMID: 18559244
30. DOR activation increased the activity of major antioxidant enzymes, glutathione peroxidase and superoxide dismutase, and decreased malondialdehyde and nitric oxide levels in the cortex exposed to cerebral ischemia/reperfusion. PMID: 19709398
31. interaction between micro- and delta-opioid receptors causes a change in the functional response to micro ligands, possibly by the formation of a micro/delta heterodimer with distinct functional properties. PMID: 12488540
32. Presence of mu, delta, and kappa opioid receptors in inner ear. May have both presynaptic and postsynaptic roles. PMID: 12855366
33. Distinct distribution patterns suggest a specific role for delta opioid receptors in the developing caudate-putamen nucleus, compared to mu-opioid receptors. PMID: 14608598
34. The predominant sites of expression of DOR genes in the rat hippocampal formation are GABAergic neurons, a finding that supports the view that opioids facilitate excitation of principal cells indirectly. PMID: 14689476
35. both negative and positive functional interaction between delta, mu and kappa opioid receptors regulate the influence of MET on H(2)O(2) and NO production in rat peritoneal macrophages PMID: 15467355
36. DOR-immunoreactive neurons may be associated with nociceptive and/or chemoreceptive function in the cranial sensory ganglia PMID: 15862537
37. the distal carboxyl tails have roles in the action of mu and delta opioid receptor hetero-oligomers PMID: 16159882
38. Delta-opioid receptor is involved in neuroprotection induced by rapid hypoxia preconditioning in cortical neurons. PMID: 16514101
39. These data demonstrate the effectiveness of a spinally administered deltaOR agonist following peripheral nerve injury and indicate deltaORs are potential therapeutic targets in the treatment of NP pain. PMID: 17175187
40. glial activation contributes to a state of opioid analgesic tolerance, & suggest that neuro-glial communication is likely responsible in part for the altered functional competence in delta opioid receptor-mediated effects following morphine treatment. PMID: 17352824
41. The present findings demonstrate a redistribution of DOR in the NAcb following cocaine withdrawal and provide anatomical evidence supporting D1R regulation of DOR function in a subset of NAcb neurons. PMID: 18417105
42. Activation of spinal cord delta opioid receptors, located on dynorphin terminals, inhibits dynorphin release. PMID: 18541716
43. Thus, data show changes in the DOR mRNA expression during the development of chronic inflammatory pain, in thalamic and brainstem nuclei implicated in pain processing mechanisms. PMID: 18572383
44. The results of these studies suggest that activation of the presynaptic delta-opioid receptor by enkephalin prevents the increase in neuronal Na(V)1.7 in DRG through inhibition of PKC and p38. PMID: 18579738
45. deactivation of inhibitory mechanisms by opioid receptor activation in the lateral parabrachial nucleus releases sodium intake if excitatory signals were activated (sodium depletion) or not PMID: 18602454
46. Here we show that DOR activity in the ventral tegmental area (VTA) robustly decreases ethanol consumption in rats and that these effects depend on baseline ethanol consumption. PMID: 19036960
47. data suggest that delta-opioid receptor activation plays an important role in neuroprotection against mitochondrial respiratory chain injury PMID: 19056363
48. extensive colocalization between alpha(2A)-adrenergic and delta-opioid receptors (DOP) on substance P (SP)-immunoreactive (-ir) varicosities in the superficial dorsal horn of the spinal cord and in peripheral nerve terminals in the skin were observed PMID: 19180644
49. Together, these findings establish distinct roles for MOR and DOR in cocaine relapse and suggest that NAc MOR could be an important therapeutic target to neutralize the effects of endogenous beta-endorphin release on cocaine relapse. PMID: 19279569
50. Inhibition of Cdk5 activity or overexpression of a delta-opioid receptor mutant lacking the Cdk5 phosphorylation site, results in low levels of delta-opioid receptor expression. PMID: 19295160

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KEGG: rno:24613

STRING: 10116.ENSRNOP00000014084

UniGene: Rn.10310