OPRD1

The OPRD1 gene encodes the delta-opioid receptor (DOR), a G-protein coupled receptor (GPCR) also known as OP1 or OPRD. Endogenous ligands like enkephalins bind to DOR, triggering Gαi/o-mediated signaling—this inhibits adenylate cyclase, lowers cyclic AMP (cAMP) levels, and modulates ion channel activity (e.g., potassium efflux and calcium influx), regulating neuronal excitability and neurotransmitter release.
DOR is linked to chronic pain, substance use disorders (opioid addiction), and mood disorders (depression, anxiety). Selective DOR agonists (e.g., SNC80) are studied for analgesia with reduced respiratory depression vs mu-opioid drugs. Antagonists and allosteric modulators are also explored to treat opioid dependence and mood-related conditions.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

OPRD1 Recombinant Monoclonal Antibody (CSB-RA947666A0HU)

Validated Data

Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate, 293 whole cell lysate, Hela whole cell lysate, U251 whole cell lysate, A549 whole cell lysate, Mouse brain tissue
All lanes: OPRD1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41 kDa
Observed band size: 41 kDa

OPRD1 Antibody (CSB-PA020188)

Validated Data

Western Blot analysis of 3T3 cells using DOR-1 Polyclonal Antibody

The following OPRD1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

OPRD1 Antibodies

OPRD1 Proteins

OPRD1 Antibodies

OPRD1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA020185	Phospho-OPRD1 (S363) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA020188	OPRD1 Antibody	Human	WB, ELISA
CSB-PA020189	OPRD1 Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-PA928803	OPRD1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA190109	OPRD1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-RA947666A0HU	OPRD1 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB

OPRD1 Proteins

OPRD1 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-CF016358PI	Recombinant Pig Delta-type opioid receptor (OPRD1)	in vitro E.coli expression system
CSB-YP016358PI1 CSB-EP016358PI1 CSB-BP016358PI1 CSB-MP016358PI1 CSB-EP016358PI1-B	Recombinant Pig Delta-type opioid receptor (OPRD1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

OPRD1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF016358HU	Recombinant Human Delta-type opioid receptor (OPRD1)	in vitro E.coli expression system
CSB-YP016358HU1 CSB-EP016358HU1 CSB-BP016358HU1 CSB-MP016358HU1 CSB-EP016358HU1-B	Recombinant Human Delta-type opioid receptor (OPRD1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP016358HU	Recombinant Human Delta-type opioid receptor (OPRD1)-VLPs	Mammalian cell

OPRD1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF016358RA	Recombinant Rat Delta-type opioid receptor (Oprd1)	in vitro E.coli expression system
CSB-YP016358RA1 CSB-EP016358RA1 CSB-BP016358RA1 CSB-MP016358RA1 CSB-EP016358RA1-B	Recombinant Rat Delta-type opioid receptor (Oprd1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

OPRD1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF016358MO	Recombinant Mouse Delta-type opioid receptor (Oprd1)	in vitro E.coli expression system
CSB-YP016358MO1 CSB-EP016358MO1 CSB-BP016358MO1 CSB-MP016358MO1 CSB-EP016358MO1-B	Recombinant Mouse Delta-type opioid receptor (Oprd1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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OPRD1

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