Recombinant Rat Ephrin type-A receptor 5(Epha5),partial

Code CSB-YP007725RA
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Source Yeast
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Code CSB-EP007725RA
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Source E.coli
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Code CSB-EP007725RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007725RA
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Source Baculovirus
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Code CSB-MP007725RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Epha5
Uniprot No. P54757
Alternative Names Epha5; Ehk-1; Ekh1; Rek7; Ephrin type-A receptor 5; EC 2.7.10.1; EPH homology kinase 1; EHK-1
Species Rattus norvegicus (Rat)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).
Gene References into Functions
  1. c-fos overexpression could upregulate EphA5 expression in hippocampal neurons of rats with congenital hypothyroidism. PMID: 29330744
  2. Downregulation of ephrinA5 and EphA5 in the CA3 region of the hippocampus may participate in the mechanism of mossy fiber sprouting and is closely associated with the development and progression of epilepsy. PMID: 29237529
  3. EphA5 promoter methylation in the hippocampus of rats with congenital hypothyroidism is associated with the levels of EphA5 expression. PMID: 26109526
  4. changes in ephrinA5/EphA5 interactions and synaptic plasticity within the ventromedial hypothalamus may contribute to the impairment in glucagon secretion and counterregulatory responses caused by recurrent hypoglycemia. PMID: 24222347
  5. ephrin-A5 and EphA5 signals play a necessary, activity-independent role in the initiation of the early phases of synaptogenesis PMID: 20824214

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Subcellular Location Cell membrane, Single-pass type I membrane protein, Cell projection, axon, Cell projection, dendrite
Protein Families Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
Tissue Specificity Almost exclusively expressed in the nervous system. Predominantly expressed in neurons.
Database Links

KEGG: rno:79208

STRING: 10116.ENSRNOP00000002793

UniGene: Rn.24569

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