Recombinant Rat Interleukin-23 subunit alpha (Il23a)

Code CSB-YP852813RA
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Source Yeast
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Code CSB-EP852813RA
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Source E.coli
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Code CSB-EP852813RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP852813RA
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Source Baculovirus
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Code CSB-MP852813RA
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Il23a
Uniprot No.
Alternative Names
Il23aInterleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19
Species
Rattus norvegicus (Rat)
Expression Region
22-196
Target Protein Sequence
VPRSSSPDW AQCQQLSRNL CTLAWSAHTP VGQMDLLREE GEEETKSDVP RIQCGDGCDP QGLKDNSQFC LQRIRQGLVF YKHLLDSDIF TGEPSLLPDS PVDQLHTSLL GLSQLLQPED HHWETQQMPR LSPSQQWQRS LLRSKILRSL QAFLAIAARV FAHGAATLTE PLVPTA
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Gene References into Functions
  1. IL23 aggravated myocardial I/R injury by promoting inflammatory responses and myocardial apoptosis. PMID: 29039526
  2. The present study suggested that IL-23 may promote myocardial ischemia and reperfusion (I/R) injury by increasing the inflammatory responses and oxidative stress reaction. PMID: 27185171
  3. Study provides evidence that IL-23/IL-23R plays a critical role in brain ischemic injury PMID: 25600958
  4. These data support the hypothesis that the E2F1-p19(ARF)-p53 pathway forms a negative feedback loop to regulate the cell cycle of renal tubular cells in the ischemic ARF. PMID: 15990448
  5. The IL-23/IL-17 axis is strongly activated in the colon of B27/Hubeta(2)m-transgenic rats with spondylarthritis-like disease. PMID: 19714651

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Subcellular Location
Secreted.
Protein Families
IL-6 superfamily
Database Links
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