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| Product Type | Recombinant Protein |
| Uniprot No. | Q9QXQ7 |
| Abbreviation | Wnt5a |
| Species | Rattus norvegicus (Rat) |
| Gene Names | Wnt5a |
| Protein Names | Recommended name: Protein Wnt-5a |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Target Details | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98%, 98% and 87% amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction. |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). |
| Subcellular Location | Secreted, extracellular space, extracellular matrix |
| Protein Families | Wnt family |
| Database Links |
STRING: 10116.ENSRNOP00000021164 UniGene: Rn.48749 |
| Pathway |
Hippo signaling pathway
Melanogenesis mTOR signaling pathway Wnt signaling pathway Signaling pathways regulating pluripotency of stem cells |
| Product Name | Recombinant Rat Protein Wnt-5a(Wnt5a),Yeast |
| Code | CSB-YP882549RA |
| Size | Pls inquiry other sizes |
| Source | Yeast |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | IIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV QTERCHCKFH WCCYVKCKKC TEIVDQFVCK |
| Expression Region | 62-380 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Rat Protein Wnt-5a(Wnt5a),E.coli |
| Code | CSB-EP882549RA |
| Size | Pls inquiry other sizes |
| Source | E.coli |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-SUMO-tagged and C-terminal Myc-tagged N-terminal His-B2M-tagged and C-terminal Myc-tagged N-terminal His-GST-tagged and C-terminal Myc-tagged N-terminal His-tagged N-terminal His-SUMO-tagged N-terminal His-B2M-tagged N-terminal His-GST-tagged N-terminal GST-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | IIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV QTERCHCKFH WCCYVKCKKC TEIVDQFVCK |
| Expression Region | 62-380 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Rat Protein Wnt-5a(Wnt5a),Baculovirus |
| Code | CSB-BP882549RA |
| Size | Pls inquiry other sizes |
| Source | Baculovirus |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | IIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV QTERCHCKFH WCCYVKCKKC TEIVDQFVCK |
| Expression Region | 62-380 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Product Name | Recombinant Rat Protein Wnt-5a(Wnt5a),Mammalian cell |
| Code | CSB-MP882549RA |
| Size | Pls inquiry other sizes |
| Source | Mammalian cell |
| Purity | >85% (SDS-PAGE) |
| Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
| Sequence | IIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV QTERCHCKFH WCCYVKCKKC TEIVDQFVCK |
| Expression Region | 62-380 |
| Protein Description | Full Length of Mature Protein |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
Wnt5a ELISA Kit for Rattus norvegicus (Rat)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL026138RA | Rat Protein Wnt-5a(WNT5A) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
Recombinant Escherichia coli 3-oxoacyl-[acyl-carrier-protein] synthase 1(fabB)
Express system: E.coli
Species: Escherichia coli (strain K12)
Recombinant Human Cytochrome P450 11B2, mitochondrial(CYP11B2)
Express system: Yeast
Species: Homo sapiens (Human)
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Express system: Yeast
Species: Macaca mulatta (Rhesus macaque)
Recombinant Human Transcription initiation factor IIA subunit 2(GTF2A2)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Complement C1q subcomponent subunit A(C1QA)
Express system: Baculovirus
Species: Homo sapiens (Human)
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