Recombinant Rat Protein jagged-1 (Jag1), partial

Code CSB-YP730923RA
MSDS
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Source Yeast
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Code CSB-EP730923RA
MSDS
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Source E.coli
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Code CSB-EP730923RA-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP730923RA
MSDS
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Source Baculovirus
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Code CSB-MP730923RA
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Jag1Protein jagged-1; Jagged1; CD antigen CD339
Species
Rattus norvegicus (Rat)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor-induced angiogenesis.
Gene References into Functions
  1. Overexpression of Jagged1 ameliorates aged rat-derived endothelial progenitor cell functions and increases its transfusion efficiency for balloon-induced rat arterial injury. PMID: 28163178
  2. Jag1 can attenuate restenosis of vein graft by inducing decreased proliferation and increased apoptosis in vivo. PMID: 25660475
  3. Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1. PMID: 24907271
  4. This is the first study to demonstrate that Jagged1 delivery transiently activates Notch signaling and increases osteogenesis. PMID: 23775982
  5. an imbalanced interaction of Jagged1 expression in periductal and periportal myofibroblasts and Notch2 expressed in cholangiocytes, may be involved in the formation of bile duct lesions in Polycystic kidney rats PMID: 23331119
  6. Data indicated that Recombinant Rat Jagged 1 Fc Chimera promoted adipogenic differentiation of mouse adipose-derived stem cells. PMID: 23046039
  7. Jagged1 protein can activate Notch signal and enhance the differentiation of MSC into cardiomyocyte, while the effect can be inhibited by DAPT PMID: 16413496
  8. Jagged1 may play a critical role in mediating the parathyroid hormone (PTH)-dependent expansion of hematopoietic stem cells, as well as the anabolic effect of PTH in bone PMID: 16647886
  9. Recombinant rat Jagged-1-mediated signaling induces a unique form of human T cell suppression whereby T cells proliferate normally upon secondary stimulation but secrete significantly reduced levels of cytokine. PMID: 17475842
  10. Jagged1 enhances the self-renewal of neural crest stem cells in vitro without affecting their sensitivity to instructive differentiation signals. PMID: 17761753
  11. Ageing enhanced vascular smooth muscle proliferation through impaired endothelial cell Jagged1 expression after vascular injury. PMID: 18079106
  12. mRNA expression of Notch-1 and its ligand Jagged-1 is upregulated in postnatal rat microglia of the corpus callosum and subventricular zone, but that of Delta-1 is reduced. PMID: 18449946

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Widely expressed in a variety of tissues.
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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