Recombinant Rat Ras-related protein Rab-3A (Rab3a)

1. analysis of crystal structures and biochemical analyses of Rabphilin-3A C2B-SNAP25 and C2B-phosphatidylinositol 4,5-bisphosphate (PIP2) complexes, revealing how Rabphilin-3A C2 domains operate in cooperation with PIP2/Ca(2+) and SNAP25 to bind the plasma membrane, adopting a conformation compatible to interact with the complete SNARE complex PMID: 28634303
2. This work has shed new light on the molecular mechanism for Rab3 and synaptotamin regulation of neurotransmitter release. PMID: 28370453
3. Rab3A-binding site on C2A domain of synaptotagmin I PMID: 28057568
4. discovery of the involvement of Rab3 and Noc2 in an insulin-regulated step in GLUT4 translocation suggests that the control of this translocation process is unexpectedly similar to regulated secretion and particularly pancreatic insulin-vesicle release. PMID: 26024738
5. Rab3A has been found to be a novel interacting protein of synaptotagmin I. Rab3A binds to synaptotagmin I in a Ca2+-independent manner. PMID: 24472545
6. the Rab3A cycle is coupled with the activation of Munc13-1 via RIM, which accounts for the regulation of secretion by Rab3A. PMID: 21689256
7. Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles PMID: 21349835
8. Selective modulation of the GTP/GDP switch mechanism of Rab27b impairs synaptic vesicle recycling and suggests that Rab27b, in concert with Rab3a, is involved in synaptic vesicle exocytosis. PMID: 20926670
9. Localization of the small monomeric GTPases Rab3D and Rab3A in the AtT-20 rat pituitary cell line. PMID: 11846002
10. role for Ca(2+)/CaM in modulating both the binding of guanine nucleotides to Rab3A and the GTPase activity of Rab3A PMID: 11879192
11. binds to granuphilin and controls exocytosis of pancreatic beta cells PMID: 12058058
12. Rabphilin-3A and Rab3A are present in normal mouse, rat, and human kidneys, with an exclusively glomerular expression and a comma-like pattern of positivity along the glomerular capillary wall, suggestive for podocyte staining. PMID: 12937130
13. The combination of Growth Inhibitory Factor with Rab3A could significantly enhance the survival of the hippocampal neurons, suggesting that GIF may inhibit Zn(2+)-induced neuronal death via its interaction with Rab3A. PMID: 15039103
14. We propose that while Rab3a preferentially associates with recycling synaptic vesicles and modulates their trafficking, Rab5a is largely excluded from recycling vesicles. PMID: 16141272
15. Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2 PMID: 16704978
16. Rab3A, but not Rab3B, enhances secretory output from rat melanotrophs and that their function is not redundant. PMID: 16822953
17. In neurons GTP hydrolysis and rabphilin are involved in Rab3A dissociation from the vesicles and the occurrence of exocytosis. PMID: 17149709
18. Young secretory granules have a higher capacity for binding Rab3A and Rab27A is functionally important for preferential exocytosis from these granules. PMID: 17311845
19. The results of this study indicated widespread distribution of RIM3gamma in diverse CNS neuronal cell types. The mRNA was found mainly in the cell bodies, the protein was localized chiefly to neuronal dendrites and to the postsynaptic densities. PMID: 17534942
20. Rab3a specifically stimulates morphological differentiation of mature oligodendrocytes PMID: 18798275
21. FLJ13130 is a novel type of Rab-GAP that exhibits broad GAP specificity and inactivates several distinct Rab isoforms, including Rab3A, just near the plasma membrane. PMID: 19077034

Show More

Hide All

KEGG: rno:25531

STRING: 10116.ENSRNOP00000026392

UniGene: Rn.44409