Recombinant Rat SH2B adapter protein 3 (Sh2b3)

Code CSB-YP021208RA
MSDS
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Source Yeast
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Code CSB-EP021208RA
MSDS
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Source E.coli
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Code CSB-EP021208RA-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP021208RA
MSDS
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Source Baculovirus
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Code CSB-MP021208RA
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Sh2b3
Uniprot No.
Alternative Names
Sh2b3; Lnk; SH2B adapter protein 3; Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; Signal transduction protein Lnk
Species
Rattus norvegicus (Rat)
Expression Region
1-368
Target Protein Sequence
MAGRTQGKHR PRVRTCPSLV PFDNPCWPPS HQPLPLQVGA PGHRVTSFLS GRAWPSYIPK GKHGLPGPRY VPDPWSLGVL GHVAPLRVTT TIFLPGASPG VMLDPACQKT DHFLSCYPWF HGPISRVRAA QLVQLQGPDA HGVFLVRQSE SRRGEYVLTF NLQGRAKHLR LVLTERGQCR VQHLHFPSVV DMLRHFQRSP IPLECGAACD VRLSGYVVVV SQAPGRKPKV VSRGGVTAST ARTKLPSWLR LLHGVIHVIS PGSSNTVLFP FSLPHWDSEL GHPHLSSAGC PPGHGAEALR GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYE MDSSSRSHLR AIDNQYTPLS QLCREANL
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
Gene References into Functions
  1. These data demonstrate for the first time that SH2B3 is a crucial mediator of post-MI inflammation and fibrosis. PMID: 25628389
  2. SH2B3 functions as a novel and effective modulator of cardiac remodeling and failure. PMID: 26101343
  3. The resulting mutation was a 6-bp, in-frame deletion within a highly conserved region of the Src homology 2 (SH2) domain of SH2B3. This mutation significantly attenuated Dahl SS hypertension and renal disease. PMID: 25776069
  4. SH2B3 inhibits neuronal differentiation of PC12 cells and primary cortical neurons PMID: 22028877
Protein Families
SH2B adapter family
Tissue Specificity
Preferentially expressed by lymphocytes in lymph node and spleen.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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